rain

Met up with my favorite DeFi Italian Stallion @emilianobonassi Had great discussions on the current state of web3, DeFi. Here are some key takeaways from our conversation.

@TheCryptoDaddi Also why don’t you just wait to eat later in the day? And have a higher calorie meal then. Unless you were planing to train and wanted energy soon beforehand

@JCHerts 1.5 today 1.5 Thursday!

@certifiedsauce1 5mg daily.

How much GHK-cu peptide are yall taking subq?

@peptidepirate I hear it's much more effective in contrast to Semax, Selank. May look into this.

@JCHerts I haven’t researched it enough yet. I have just started to hear about this one. I am looking into it 🤝

Selank/semax 🔬 Day 5 update.. This stuff definitely works.🏴‍☠️ Focus in the gym 💯 Ability to lock in on task💯 Sense of calmness 24/7💯 Small sense of euphoria 💯 Seems day 5 is where the effects really start to hit 🏴‍☠️ (Research purposes only I am a dumb faceless pirate, never take advice from someone like me)🏴‍☠️🏴‍☠️

@TheCryptoDaddi May be also to do with the low calorie intake, as people eat less

I have seen a TON of people mention anhedonia while taking Retatrutide, which is the inability to find pleasure in the things you used to. I’ve been on Reta for a while now and I still want to make money, be a good dad, bang my girlfriend non-stop, shoot my guns, and ride my motorcycles. This has never been an issue for me. It could be because I’ve never dosed over 2 mg of Reta a week, but I can only speak for myself when I say anhedonia has never been an issue for me.

@TheCryptoDaddi Do you feel like Tesa is worth taking? If already lean, don't think Tesa would help much, unless it could help with muscle gains and recovery. But then other alternatives would be better for that (TRT).

I’m 35 and take - Retatrutide for effective weight loss - Tesamorelin for visceral fat loss via GH release - Kisspeptin for boosting LH/FSH and testosterone - BPC-157 for accelerated tissue healing and repair - MOTS-c for enhanced mitochondrial metabolism and insulin sensitivity - DSIP for deeper, restorative sleep

@TheCryptoDaddi Curious on the Epitalon results

The last peptide cycle i ran the following stack: Kisspeptin Tesamorelin Retatrutide BPC-157 DSIP MOTS-c I’m considering doing things slightly different this time around: CJC-1295 (no DAC) / Ipamorelin BPC-157 / TB-500 GHK-Cu 4AOD-9604 Epitalon​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​ Reta

@TheCryptoDaddi Are you keeping calorie intake the same? A good experiment would be to keep calories the same and see if upping Reta has any effects. Could validate that Glucagon is playing a role

I have decided to up my dose next week of Reta to 3mg from 2mg. As long as no side effects occur, I’m going to ultimately move up to 4mg and stay there. Reading a good bit on results really showing at the 4mg mark. To be clear, 2mg is working fine… but I want to personally push the envelope a bit and see if going from 2>4 has any noticeable effect for me. In the name of science, FOR RETATRUTIDE!!!!

@fitcapdefi Do you plan to cycle off Reta?

peptides that will be in forever rotation retatrutide mots-c bpc-157 + tb-500 ghk-cu the reta at a low maintenance dose once im done with this cutting cycle will be something i run year round mots-c i will be cycling multiple times a year bpc + tb anytime injuries arise ghk will be cycling multiple times a year there may be more i add to this list but these are for sure my top 5 at the moment what are some peptides you will never stop using?

@BoJaxGOAT @fitcapdefi What makes you like Tesa? Visceral fat reduction or other properties?

@fitcapdefi Man I love tesamorelin so much, would be hard to kick that one out. But yeah I would say Reta and MOTS-C

@jefftangx Have you tried NAD+ too?

Day 4 on MOTS-c Completely killed my desire to drink coffee/tea/Celsius as soon as I wake up Crazy

@barnabasdotexe @EricTopol @Nature ah guess not.

@JCHerts @EricTopol @Nature No glucagon, not Reta.

New @Nature A quintuple [GLP-1 + 4 other] receptor agonist drug that exceeds effects of the dual receptor (GLP-1 and GIP, tirzepatide) in the experimental model vs diabetes and obesity (in case you thought a dual receptor was max effect, as also seen with retatrutide, a triple receptor agonist) nature.com/articles/s4158…

@sundarpichai @GeminiApp So neat, wish I had this when I was younger haha

You can now ask Gemini to create Docs, Sheets, Slides, PDFs, and more directly in your chat. No more copying, pasting, or reformatting, just prompt and download. Available globally for all @GeminiApp users.

@DrJesseMorse People will still use tirz over retatrutide due to stronger appetite suppression and reduced increased heart rate. I don’t think it’s a one size fits all here

Some thoughts on GLPs. Fast forward 5 years from now. We will see that for all the ‘weight loss’ drugs and peptides, the field will keep advancing. The first real successful one was Ozempic/Semaglutide starting 2017, and really becoming popular over the last 2-3 years. As the side effects mounted, people sought other answers. Enter Mounjaro/Tirzepatide, which was approved in 2022, and it was more effective for weight loss, less muscle wasting, and less side effects (nausea, gastric emptying). Then over the past year or so people have been exposed to the next big GLP1: Retatrutide predominantly via the black/gray market. Reta targets 3 receptors, compared to ozempic’s 1 and mounjaro’s 2. My guess is this will be formally available in late 2026 or early 2027 once the drug trials are completed, and it will dominate for the next 2 to 5 years. Potentially a trillion dollar drug. Why? Because it is significantly more effective than both Ozempic and Mounjaro for weight loss, very little side effects (no nausea or muscle wasting), has benefits for liver fat, inflammation, osteoarthritis pain and overall metabolic syndrome. I wouldn’t be surprised if it is seen as anti-cancer and anti-aging as well. Going forward, we will see that as the pharmaceutical companies continue to add drugs that target more receptors, the potency and treatment options/possibilities will increase, but the side effects will decrease. We will see that their side effect profiles of Ozempic/Semaglutide or Mounjaro/tirzepatide are very poor (comparatively) and there are better, safer and more cost-effective options. As a result, people will no longer recommend Ozempic/Semaglutide or Mounjaro/tirzepatide. The new ones will not only target weight loss, but also optimize blood sugars, abdominal fat, cravings, overall inflammation as well as work on building muscle. Gone will be the slow gastric emptying, which has caused significant issues with anesthesia, as well as the significant muscle wasting, in particularly in the face (‘Ozempic face’) and glutes. The future is bright and filled with less side effects!

@stacy_muur Regulations and banning

The US has Uniswap, Circle, Chainlink, Hyperliquid, Phantom, MetaMask, etc. Asia has PancakeSwap, Tron, Trust Wallet, SushiSwap, Meteora, Aster, etc. EU has _______?

@stacy_muur I imagine Claude and Codex getting better contributed to this

Full list of protocols & pool exploited in April ↓ Aftermath Finance: $ unkown Judao: $228,000 Singularity Finance: $413,000 ZetaChain: $300,000 Scallop Lend: $150,000 Purrlend: $1,500,000 Giddy: $1,300,000 Kipseli: $80,000 Volo Vault: $3,500,000 Thetanuts Finance: $50,000 Juicebox V3: $52,000 KelpDAO: $293,000,000 Grinex: $15,000,000 Rhea Lend: $18,400,000 Zerion Wallet: $100,000 MONA: $60,950 Dango: $410,000 SubQuery Network: $60,000 Hyperbridge: $2,500,000 Aethir: $423,000 BSC TMM/USDT: $1,665,000 Silo V2: $392,000 Drift: $285,000,000 LML/USDT staking protocol: $950,000 This is the 24th hack this month. More than $624,000,000 stolen in total. And it's not even the end of the month...

@TheCryptoDaddi NAD, GHK CU, KPV.

Out of all the peptides that are out there what is one peptide you won’t take and one peptide you can’t go without? There’s so much hype about peptides and I’m only super familiar with Retatrutide, Tesamorelin, DSIP, Kisspeptin, BPC-157 and MOTS-c. However, I’m genuinely curious about researching more of them. Let me hear em 👇🏼

@TheCryptoDaddi Keep us up to date on that. I actually like KPV better, it yields better results imo. GHK is good too!

@JCHerts Gonna do a NAD+ drip here in the next few weeks! I do need to check out GHKcu though! Have some KPV but haven’t started on that yet