Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming
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JCI insight
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JCI insight
@JCI_insight
High-quality basic & translational research representative of biomedical specialties & physician-scientists. Bluesky: https://t.co/AksMLnEAMq
Katılım Ekim 2016
2.4K Takip Edilen39.9K Takipçiler
Revealing the epigenetic modulator lysine-specific histone demethylase 1a as a new target for kidney diseases
doi.org/10.1172/jci.in…
Here, Tobias B. Huber @Tobias_B_Huber & team @UKEHamburg use a state-of-the-art, tour de force experimental design to show LSD1 regulates kidney development, and its dysfunction disrupts key kidney cells, leading to cyst formation in mouse and organoid models.
The image shows severe structural changes in the adult mouse kidney with loss of KDM1a.
#Nephrology
#KidneyDisease
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JCI insight retweetledi
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The increased thermogenesis in the formerly white adipocytes was NOT from UCP1. Rather, up to 80% of thermogenesis was from the futile creatine cycling @kazaklab . Credit to #Kelly_Long and #Cheyl_Cero.
Daniel J Drucker@DanielJDrucker
Here the authors propose that treatment of adipocytes with BMPs results in an energy expending phenotype without transdifferentiation into beige adipocytes, providing a new approach to treat #obesity related metabolic disease. @JCI_insight insight.jci.org/articles/view/…
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Is p53 mutational status alone enough to predict poor prognosis among patients with #AML?
doi.org/10.1172/jci.in…
Here, ASCI member Sami N. Malek & team @UMichMedSchool quantitatively define patients with AML who have WT TP53 but defective TP53-mediated apoptosis, revealing that this group has a dismal long-term survival.
The figure shows survival of patients with AML stratified by biomarkers.
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Dr. Vivien Sheehan led a team of researchers in identifying four genes that expressed more during #SCD pain crises. Their research found that IL-beta was expressed the most, making it the best pain event biomarker for further studies. Learn more: insight.jci.org/articles/view/….
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What happens when brain people meet bone people? A study of bones in neurodegenerative disease: insight.jci.org/articles/view/…
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A new model for alveolar macrophage-Mycobacterium #tuberculosis (#TB) interactions!
doi.org/10.1172/jci.in…
Michael S. Glickman @MichaelGlickma1 & team @MSKCancerCenter establish a stem cell–derived lung alveolar macrophage model to reveal itaconate functions differently between human macrophage types in the host defense against Mtb:
The figure: Brightfield and stained images of two macrophage populations.
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JCI insight retweetledi
Here the authors propose that treatment of adipocytes with BMPs results in an energy expending phenotype without transdifferentiation into beige adipocytes, providing a new approach to treat #obesity related metabolic disease. @JCI_insight insight.jci.org/articles/view/…
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@nupharm1 @NUFeinbergMed Vanderbilt University @VanderbiltU features Clowes Moster et al.: buff.ly/71XThsX
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@nupharm1 @NUFeinbergMed Behind the scenes: First author, Katherine Clowes Moster, screening images to identify trafficking correctors of KCNQ1.
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Long QT syndrome is a life-threatening #cardiac #arrhythmia for which current therapies don’t correct the molecular defect
doi.org/10.1172/jci.in…
Alfred L. George, Jr. @nupharm1 & team @NUFeinbergMed now identify the first trafficking corrector for KCNQ1 mutations that cause #LQTS—the small molecule VU0494372 increases KCNQ1 cell surface levels, total levels, and surface trafficking efficiency in a dose-dependent manner in mammalian cells.
The images show VU0494372 increases cell surface and total KCNQ1.
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Excited to share our latest work! 🧬
#exomer TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis. Grateful to my mentors @MarbanLab @TheIbrahimLab and to all the authors and excited to see it out in @JCI_insight ! Supported by @CIRMnews
#RNAtherapeutics
JCI insight@JCI_insight
This Research Letter offers a creative approach to #sepsis based on a naturally occurring efferocytosis-enhancing RNA doi.org/10.1172/jci.in… Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis by @AleCiulloPhD, @Marbanlab, @TheIbrahimlab & team @CedarsSinai. The image shows exposure to TY2 increases E. coli clearance by bone-marrow derived macrophages as indicated by fluorophore as a reporter of efferocytosis (green).
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TY2 is our second #ncRNA #drug in clinical development based on the #CREDO discovery paradigm— this one is amazingly potent and effective in clearing #interstitial #debris! Work supported by @CIRMnews
JCI insight@JCI_insight
This Research Letter offers a creative approach to #sepsis based on a naturally occurring efferocytosis-enhancing RNA doi.org/10.1172/jci.in… Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis by @AleCiulloPhD, @Marbanlab, @TheIbrahimlab & team @CedarsSinai. The image shows exposure to TY2 increases E. coli clearance by bone-marrow derived macrophages as indicated by fluorophore as a reporter of efferocytosis (green).
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@AleCiulloPhD @MarbanLab Behind the scenes: Ciullo and team develop an exomer drug based on a naturally occurring RNA and investigate its bioactivity in acute sepsis.
@AleCiulloPhD @TheIbrahimLab @MarbanLab @Kara_tsi @anhhnguyennn9 @Hiroaki_komuro @XMichaelJonesMD @SmidtHeart
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This Research Letter offers a creative approach to #sepsis based on a naturally occurring efferocytosis-enhancing RNA
doi.org/10.1172/jci.in…
Small noncoding RNA TY2 enhances efferocytosis and improves outcomes in a mouse model of sepsis by @AleCiulloPhD, @Marbanlab, @TheIbrahimlab & team @CedarsSinai.
The image shows exposure to TY2 increases E. coli clearance by bone-marrow derived macrophages as indicated by fluorophore as a reporter of efferocytosis (green).
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Reduced osteogenic factors and early osteoblast senescence in SOD1(G93A) ALS mouse model
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In #ALS, bone changes have largely been attributed to disuse.
doi.org/10.1172/jci.in…
Francesco Roselli @RoselliLab & team now report accelerated senescence of bone cells before the onset of neurological symptoms, due to reduced sensitivity to osteogenic mediators, in a mouse model of ALS.
The figure shows distal femurs with weakly mineralized bone (red), moderately mineralized bone (yellow), and highly mineralized bone (blue) in WT and ALS model mice (SOD1) at presymptomatic (p45) and symptomatic (p110) stages, in which early trabecular thinning and reduced mineralization precede cortical bone loss.
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@Sudrishti @ArteelBeier @PittTweet α-Diversity analysis of hepatic transcriptome reveals distinct pathways in alcohol-associated hepatitis
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✨Presenting a methodological advancement that bridges ecological theory with clinical #hepatology✨
doi.org/10.1172/jci.in…
Here, Sudrishti Chaudhary @Sudrishti Gavin E. Arteel @ArteelBeier & team @PittTweet perform alpha diversity analysis of hepatic transcriptome, revealing distinct pathways in alcohol-associated #hepatitis and offering new perspectives on disease progression and identifying potentially informative biomarkers.
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