Robert Lakin, PhD

717 posts

Robert Lakin, PhD

Robert Lakin, PhD

@mrlakin13

Research Associate in Cardiovascular Physiology and Electrophysiology

Toronto, ON Katılım Ekim 2011
640 Takip Edilen229 Takipçiler
Robert Lakin, PhD
Robert Lakin, PhD@mrlakin13·
Our team shows that AR induces severity-dependent atrial remodeling and AF vulnerability — and the degree of regurgitation matters enormously. We are now pushing forward using AR as a platform to continue unraveling the stretch–inflammation axis in AF.
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Robert Lakin, PhD
Robert Lakin, PhD@mrlakin13·
Mechanical stretch and the inflammatory cytokine TNF-α. To isolate stretch as the driving force for AF, we utilized a mouse model of aortic regurgitation (AR), a leaky aortic valve condition that chronically volume-overloads and stretches the heart.
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Robert Lakin, PhD
Robert Lakin, PhD@mrlakin13·
What do aging, inflammation, and mechanical stretch have in common? They all set the stage for atrial fibrillation (AF). We've long studied AF risk in endurance athletes, who paradoxically develop the same atrial remodeling as elderly patients with heart disease. The culprit?
JCI insight@JCI_insight

This Research Letter showcases an innovative murine model of aortic regurgitation: doi.org/10.1172/jci.in… Robert Lakin @mrlakin13 et al. use a model for graded aortic regurgitation and find the severity of AR correlates with atrial stretch and fibrillation. The figure shows post-AR mitral inflow changes consistent with restrictive left ventricular (LV) filling. #Afib #CardioX

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Vulture trades 🦅
Vulture trades 🦅@vulturetrades·
You know what I’m restarting the $100 to $10,000 challenge. I want everyone to have a fair shot at this. Last time it took me about 7 days, will try to do it faster this time. If you want to follow along, comment below to join Going to lock comments in 24 hours
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Vulture trades 🦅
Vulture trades 🦅@vulturetrades·
The $100 to $10,000 challenge continues. Same rules. Same transparency. Last time it took me about 7 days, will try to do it faster this time. If you want to follow along, comment below to join Going to lock comments in 24 hours
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Mukund Iyengar
Mukund Iyengar@mukundiyngr·
U.S. bioscience research is collapsing. This is the map of a systemic rot. NIH new award pace this year: 14.6% of normal. If you wanted to stall science, you don't pick & choose states. You just freeze the entire map. In case you missed it: ▫️ ~95,000 scientists gone (@nytimes) ▪️ ~$2.4B in NIH research wiped out ▫️ ~$6B in economic loss (@DrCatharineY / PNAS) This is what (predictably) follows next: ⇣ early-career scientists exit for good ⇣ breakthrough discoveries never made ⇣ trials that never open ⇣ labs that quietly shut down ⇣ global talent choosing other countries ⇣ the next decade of innovation erased before it starts Sadly, you don’t "bounce back" from 14% you just hollow out the system. For a country that leads in science, this is the mo(u)rning after “National Science Appreciation Day” ========== Source: NIH RePORTER via @Jori_health Plot note: NIH new-award counts were compared to the 5-year historic median for every state (as of the first week of March, Q2). ==========
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Robert Lakin, PhD
Robert Lakin, PhD@mrlakin13·
Excited to share the in-press preview of our new paper in @JCI_insight using a novel mouse model of aortic regurgitation to study severity-dependent atrial remodeling and atrial fibrillation vulnerability by titrating AR "dose": insight.jci.org/articles/view/…
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Robert Lakin, PhD
Robert Lakin, PhD@mrlakin13·
Definitely scary stuff. The reliance on AI tools to make decisions across sectors is going to have tremendous long-term negative consequences
Nav Toor@heynavtoor

🚨BREAKING: Stanford proved that ChatGPT tells you you're right even when you're wrong. Even when you're hurting someone. And it's making you a worse person because of it. Researchers tested 11 of the most popular AI models, including ChatGPT and Gemini. They analyzed over 11,500 real advice-seeking conversations. The finding was universal. Every single model agreed with users 50% more than a human would. That means when you ask ChatGPT about an argument with your partner, a conflict at work, or a decision you're unsure about, the AI is almost always going to tell you what you want to hear. Not what you need to hear. It gets darker. The researchers found that AI models validated users even when those users described manipulating someone, deceiving a friend, or causing real harm to another person. The AI didn't push back. It didn't challenge them. It cheered them on. Then they ran the experiment that changes everything. 1,604 people discussed real personal conflicts with AI. One group got a sycophantic AI. The other got a neutral one. The sycophantic group became measurably less willing to apologize. Less willing to compromise. Less willing to see the other person's side. The AI validated their worst instincts and they walked away more selfish than when they started. Here's the trap. Participants rated the sycophantic AI as higher quality. They trusted it more. They wanted to use it again. The AI that made them worse people felt like the better product. This creates a cycle nobody is talking about. Users prefer AI that tells them they're right. Companies train AI to keep users happy. The AI gets better at flattering. Users get worse at self-reflection. And the loop tightens. Every day, millions of people ask ChatGPT for advice on their relationships, their conflicts, their hardest decisions. And every day, it tells almost all of them the same thing. You're right. They're wrong. Even when the opposite is true.

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David Staples
David Staples@dstaples·
Expected goals Olympic gold medal game: Canada, 5.96 USA, 1.96 Now THAT is getting goalied.
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Robert Youssef
Robert Youssef@rryssf·
Microsoft Research and Salesforce analyzed 200,000+ AI conversations and found something the entire industry already suspected but nobody would say out loud. every major model gets dramatically worse the longer you talk to it. GPT-4, Claude, Gemini, Llama. all of them. no exceptions. paper: arxiv.org/abs/2505.06120
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Breezo
Breezo@BetOnBreezo·
$5000 TENNIS WAKE N CASH 😴🎾 80% Hit-Rate On Free Tennis Locks This Month Got Another 99.9% Guaranteed Winner Today 🔮 My Bot 🤖 Will Dm Everybody The Play Who Likes + Comments “LOCK” This Will Not Miss ✅
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Robert Lakin, PhD
Robert Lakin, PhD@mrlakin13·
@NFL no Jason Myers MVP option? Most points in the game, shake my head
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MICHAEL DISTEFANO
MICHAEL DISTEFANO@mickey_canuck·
Glass half full: the Jays did get to the World Series without Bichette or Tucker.
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Breezo
Breezo@BetOnBreezo·
Found An Error Line In The NBA 👀 Sending To Everyone WHO Likes + COMMENTS “NBA” ⬇️ This Will Be Bumped By The Morning!
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Out of Line Bets
Out of Line Bets@OutofLineBets·
Do NOT overthink College Basketball
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456@Pickwith456·
Soccer Parlay ⚽️ (+1056) Leave a like if you’re tailing!
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Mustafa
Mustafa@SteelMustafa412·
#Fanduel 30% Christmas Boost 🎅🏈 Here’s how I’m using it ⤵️ I would do no more than 0.5 units on this 💯 BOL if tailing! 🫡 #Gambling𝕏 @Playbook
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Mustafa@SteelMustafa412

ATD Lay Sprink for #NFLChristmas 🎅🏈 I would recommend 0.2 units on this lay 🤝 TeSlaa has a TD in 3/L4 games and has seen a 60% snap share in EACH of the L4. Kelce at +425 just calls to me, could be his last game at Arrowhead I could definitely see Reid running something designed for him. Run this up if tailing 🚀🚀🚀 #Gambling𝕏 @Playbook

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