Jeremy Baskin

Thrilled to share this #lipidtime story in @JCellBiol where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!

Today in @Nature we report how AI-guided redesign enhances protein evolution. Integrating ProteinMPNN sequence design with autonomous laboratory evolution, we establish a workflow to engineer enzymes with improved properties over those evolved from natural proteins. Redesigned starting points consistently evolve an expanded fitness landscape, reaching new function with higher activity, specificity, and stability than their natural counterparts. drive.google.com/file/d/1C-QYcx… 1/14

New preprint! We find that fatty acid double-bond geometry alters their metabolic fate and ferroptosis sensitivity. Trans fatty acids are metabolized differently from their cis counterparts, reshaping membrane phospholipids and ferroptosis sensitivity. biorxiv.org/content/10.648…

Metabolic Labeling and Visualization of Isoprenoids Using Alkyne‐Modified DMAPP Analogs in Bacillus subtilis - Hulsey - Angewandte Chemie International Edition - Wiley Online Library onlinelibrary.wiley.com/doi/full/10.10…

Hey friends, we're hiring over here at Princeton BioE! In addition to the usual positions (faculty, grad students, postdocs), BioE is looking for a Program Manager to oversee big multi-PI projects (e.g. DARPA, ARPA-H). Pass along & apply if interested! apply.interfolio.com/187973

The last leg of my trip to Japan was at the 55th Naito Conference on Chemical Biology: inspiring science in beautiful Hokkaido at the incomparable Chateraisé Gateaux Kingdom — a 3-in-1 hotel, spa, and sweets factory. I’ve been surrounded by so many delicious lipids all week! 🤤

Excited and grateful to have been promoted to Professor. Many thanks to the outstanding students and postdocs in my lab and to my colleagues at Cornell and across the #chembio and #lipidtime communities for your continued support!

@RyosukeKojima4 @UTokyo_News @MizLabUT I enjoyed our discussion immensely, Ryosuke, and I hope that you feel better soon!

@basktastic @UTokyo_News @MizLabUT This is Ryosuke Kojima from UTokyo. Thank you for visiting UTokyo, and it was a great pleasure to e-meet and discuss with you! I’m sorry I could only join online due to illness, but I truly enjoyed our fruitful discussion. I look forward to meeting you in person next time!

Fantastic #lipidtime conversations yesterday at @UTokyo_News — thank you to @MizLabUT for hosting my visit!

What do lipid droplets do in neurons? Thrilled to share the 🌟1st preprint from my lab, led by Eleni Katafygiotou, showing activity-dependent formation of neuronal LDs in vitro and in vivo, and the impact of LD modulation on neuronal function and behavior. biorxiv.org/content/10.648…

Today’s impressive lineup of speakers include former awardees of The Ono Initiative Jonathan Long @longlabstanford, Yamuna Krishnan @UChiChemistry, Xiaoyu Zhang @NorthwesternU, @fordycelab, @basktastic, @StacyMalaker, and @angadmehta as well as keynote speaker @ChemicalBiology!

Good #lipidtime parody: inpreparation.substack.com/p/biophysical-…

How to determine the proteome of cellular compartments? We established a method to do just that, published in @elife: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLife.…

Goodbye Dresden and Pillnitz! Had a blast @mpicbg and the ESBOC annual bioorganic chemistry meeting — a #lipidtime #chembio 1-2 👊. Thanks to @nadlerlab and Ben Schumann for the invitation, great to see @FiedlerLab @FedorovaLab and other friends!

Our May issue is live! nature.com/nchembio/volum… The cover image depicts the vulnerability of the non-transcribed strand of genes to oxidized guanines and abasic sites

A new CRISPR-based genetic toolkit enables genome-wide, single-cell gene analysis in fruit flies. This will speed up gene discovery and reveal insights into brain function, development, and disease. Developed by researchers at @Cornell. Read more: bit.ly/421Ofi0

The Booker Lab at the University of Pennsylvania, in Philadelphia, and HHMI is searching for a lab manager. If interested, please apply at the HHMI link below.hhmi.wd1.myworkdayjobs.com/en-US/External…

Thrilled to welcome @mbogyo, @danetteldaniels, @SlavoffL, and Marcey Waters to @CornellChem for today’s annual Chemistry-Biology Interface Symposium!

I had a blast visiting the @omenndarlingbio @Princeton yesterday! Thanks so much to @tinakim_neuro for hosting my visit! @christhechang @KleinerLabRNA

Hello, @Princeton! Excited for my visit to @omenndarlingbio tomorrow 😃