Jeremy Baskin

New paper @JCellBiol! We found a new regulator of p62 phase separation, autophagy, and antioxidant signaling — it is an E3 ligase adaptor called SHKBP1 but the effect is via direct p62 binding, not ubiquitination. Congrats to Lin Luan & team! rupress.org/jcb/article/22…

Special day @CornellChem: welcoming back PhD alum Xiaoyu Zhang (Hening Lin lab) from @NUChemistry for a phenomenal seminar on targeted protein degradation and chemical immunology!

Methods in Enzymology, Volumes 726-728: Lipids & Membranes Vol 726: Detection by Imaging & Lipidomics sciencedirect.com/bookseries/met… Vol 727: Dynamics & Interorganelle Transport sciencedirect.com/bookseries/met… Vol 728: Metabolism, Lipidation, & Lipid-Protein Interactions: coming soon!

I've been leading a big project at Methods in Enzymology over the past year: editing back-to-back-to-back volumes describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

How moss makes a spiral of leaves through a rotating asymmetric division of the apical cell meristem--our paper is out @CurrentBiology today! @StraussSoe @RichardSmithLab @Joesophila cell.com/current-biolog…

A Postdoctoral Associate position is available in the Roeder Laboratory at Cornell University in Ithaca, NY with a focus on researching Polyploidy. Apply by March 1. Please spread the word. apps.hr.cornell.edu/recruiting/fac…

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @RMedzhitov @YaleIBIO nature.com/articles/s4157…

Lin Luan, Jeremy Baskin @basktastic et al. @weillinstitute @CornellChem identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. hubs.ly/Q04271ml0 #CellSignaling

Check out our new chapter in Methods in Enzymology on inhibition of #sterol protein function! Here @HoganBryceRoge1, @Laura_dta and @tomeveriss describe in detail our assay cascade to identify inhibitors of sterol transport proteins. (1/2) sciencedirect.com/science/chapte…

It was fun writing this book chapter on methods to trace #lipid metabolism. Congrats to Alec and Helene! Thanks to @basktastic for the invitation to contribute this chapter. #lipidtime @OHSUNews sciencedirect.com/science/chapte…

Membrane editing with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles nature.com/articles/s4158…

LipoID profiles lipid droplet interactions and identifies interorganelle regulators nature.com/articles/s4158…

Bump-and-hole engineering of xylosyltransferase isoenzymes XT1 and XT2 enables substrate profiling and modification of proteins as designer proteoglycans to modulate cellular behavior #glycotime nature.com/articles/s4158…

Janelia is hiring Group Leaders! Work alongside superstars like Luke Lavis, @JiefuBiol, @mengwang939, @JLS_Lab, @ERSchreiter. If you have ideas that are perhaps too ambitious or crazy for a traditional academic setting, that is exactly who they are looking for. Tool-builders at all career stages with original, transformative ideas for experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, and methods that don’t yet exist: Apply by Feb. 3, 2026: janelia.org/groupleader

Can we design mutations that predictably bias proteins towards desired conformational states? Today in @ScienceMagazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations. science.org/doi/10.1126/sc…

Video introduction to our new “Conformational Biasing” method for computational design of mutations that bias proteins towards desired conformational states CB part starts at 14:55 youtube.com/watch?v=4v_ZqW… Thanks to @PeterECavanagh and Andrew Xue – amazing graduate students who co-led this work

Mind the GAP 🚧🕳️🚧 Excited to share the latest preprint from the @Fromme_Lab showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵: biorxiv.org/content/10.648…

Curious about how organelles interact in live cells? Our latest method paper showcases a fluorogen-activated toolkit for visualizing contact sites in real time! sciencedirect.com/science/chapte…

Congratulations to Shiying Huang, the lab’s 11th PhD graduate, on passing her @CornellChem B exam today! Check out her recent preprint here: biorxiv.org/content/10.110… So much to celebrate and be thankful for! 🎓🎉

Congratulations to Dr. Lin Luan, the lab’s 10th PhD graduate, on passing her B exam today!