Jae-Hyun Yang

Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/

This paper is dedicated to our friend Michael Bonkowski, who greatly contributed to the initial submission in 2019.

[12/12] Questions still remain. What about humans? At the single cell level? What other stressors cause epigenetic aging? What factors mediate the process? Where is a backup copy of youthful epigenetic information?💾

[1/12] From yeast to humans, epigenetic information is lost over time. Is it a cause or a consequence of aging? What causes it to be lost? Possible to restore it? I am thrilled to share our huge collaborative effort published today. authors.elsevier.com/c/1gPf5L7PXir3R