Jake Montgomery

This was a really fun project for me and it gave me an opportunity to work with some great folks at Bayer where they are trying to combat herbicide resistant weeds every day. If you made it this far, thanks for reading my first paper thread! 7/7

This supports other experiments that suggest epyrifenicil will be able to control weeds that are resistant to some other PPO-inhibiting herbicides like lactofen or fomesafen. We found some new mutations, but these are tightly linked with G210 and are probably not important. 6/7

Out this week in Weed Technology, a paper describing the project I helped with while I was an intern at @Bayer. Read the full story here cambridge.org/core/journals/…. I usually don’t do these threads, but here goes nothing. 1/7

Latest work from the lab led by @yuhunghung in @ThePlantJournal! We engineered a RNA-binding protein to sort and protect a Cas9 transcript for long term expression! Can be applied to any engineered transcript as a UTR: onlinelibrary.wiley.com/doi/10.1111/tp…

Following the firing of thousands of young USDA scientists yesterday, I will no longer be posting on this platform. You can find me on LinkedIn and Instagram.

New preprint! We find a novel signal of positive selection in georeferenced genotype data, then use this signal to identify in-progress selective sweeps in the malaria vector Anopheles gambiae: biorxiv.org/content/10.110…

Right after the WSSA GSO Student Luncheon, we’ve got an exciting Panel Discussion lined up! Hear firsthand insights from experts across industry, academia, and government—perfect for anyone looking to grow their network and gain fresh perspectives. Bring your questions! 🙌

🚨 WSSA Student in-person Webinar! 🚨 Dive into Protein Modeling of Herbicide Resistance 🧬🌿 🗓️ Feb 25 ⏰ 4:45 💻 Bring your laptop & download pyMOL before the workshop! [pymol.org/2/]

CASTER: Direct species tree inference from whole-genome alignments. Super proud to have made small contributions to this incredibly clever work by the amazing Chao Zhang and his PhD advisor S. Mirarab. science.org/doi/10.1126/sc…

New episode is available! This week we have Dr. Todd Gaines on to talk about some novel genetic methods to control weeds. He covers the evolution of genomics and how it's helping scientists understand and combat herbicide resistance. Thanks for listening!

The Slotkin lab is hiring for an exciting project that involves gene editing, transposable elements and plant transformation! Please RT! paycomonline.net/v4/ats/web.php…

New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30

Biggest medical discoveries of the week (🧵) 1/8 An engineered insulin, NNC2215, whose activity is adjusted by glucose concentration Its affinity for the insulin receptor drops >3-fold when glucose levels fall - reducing the risk of hypoglycaemia nature.com/articles/s4158…

Many new machine learning tools for protein engineering have popped up in the last year. In these early days, it might be unclear how to actually use them for real molecular design tasks in industry. We demonstrate how to engineer a cholesterol drug and plastic degrading enzymes in detail. 1\N

Curious about how major weed species are related? I published this phylogeny of ALS gene sequences from all the species currently hosted on WeedPedia along with the story of the international Weed Genomics Consortium. Check it out: doi.org/10.1564/v35_au…

Characterization of a novel eccDNA carrying both glyphosate and glufosinate target site due to co-duplication of their chromosomic native region - @theweednaldo @CuttiLuan @AimonePorri Ingo Meiners, Jens Lerchl, @GenomEric @NorsworthyJason