James Gallagher

Out now in @NatureSynthesis, we drive an endergonic Diels-Alder reaction energetically uphill by chemical fuelling. Reminiscent of anabolism in biology, we hope that an understanding of endergonic synthesis will help expand the chemist's toolbox. nature.com/articles/s4416…

Find the thread on the other place. User: jamesgallagher

In biology, molecular machines exist to perform useful functions. Artificial molecular machines now move in the same way as those in biology, but they do not yet perform tasks. Out now in @Chem_CP , a guide to task performance in molecular machinery. cell.com/chem/fulltext/…

@EPenocchio @DeanAstumian Cool! Ofc Hammond not always relevant, but it nicely shows that kinetic asymmetry /can/ be a function of the power stroke. So "x doesn't matter y does" is not very satisfying when y = f(x)!

Great to see this paper out, but as you correctly show, the determinant of directionality is kinetic asymmetry, not the power stroke. Switch the kinetic asymmetry but keep the power stroke constant and the direction of rotation switches sign.

@DeanAstumian An interaction that significantly lowers an activation barrier will also significantly lower the energy of the ground state (given Hammond). Perhaps the binary of kinetic asymmetry vs. power stroke is not useful if in many cases one depends on the other.

@DeanAstumian been thinking for a while: Given the Hammond postulate, is it chemically realistic to have very large kinetic asymmetry and NOT have a power stroke in the same direction. In other words, is it chemically realistic to "switch the kinetic asymmetry and keep power stroke the same"?

@RSC_MASC much appreciated!

Many excellent nominations were received, and the judging panel decided to award two Highly Commended awards to Lei Chen (University of Manchester, De Bo group) and James Gallagher (University of Manchester, Leigh group). Congratulations Lei and James!

We are delighted to announce that the 2024 RSC MASC Group PhD Thesis Award given in memory of John Fossey is awarded to Peter Gallagher @PeterrGallagher from the University of Birmingham. Peter works in the group of @sgoldup Many congratulations! mascgroup.co.uk/prizes-awards/…

Online now: Out-of-equilibrium compartments: Thinking inside the box dlvr.it/TGPpK7

A pleasure to Preview recent work by @EPenocchio, @DeanAstumian and @giuliosflask for @Chem_CP. Life is defined by its compartments, find out how 'thinking inside the box' helps us to understand nonequilibrium systems here: sciencedirect.com/science/articl… sciencedirect.com/science/articl…

@FieldenStephen @royalsociety @UoBChemistry congrats steve!

Really excited to announce that I've been awarded a @royalsociety Dorothy Hodgkin Fellowship to be hosted @UoBChemistry from early next year. Grateful for the opportunity to build a research group that will study complex nanoparticle systems. PhDs to be advertised soon!

June issue live🥳 Mirror-image cyclodextrins Endergonic synthesis On-liquid-gallium surface synthesis Isolation of a pentadienyl-type radical In situ generation of reactive (di)gallenes (Continued) nature.com/natsynth/volum…

Finally, after 5 years working on it with @StefanBorsley and @ProfDaveLeigh, here is our review on ratchet mechanisms in molecular machines and beyond onlinelibrary.wiley.com/doi/10.1002/an…. This started out as the intro to my report for my first year of PhD

Five years in the making with @benjamino_acid and @ProfDaveLeigh! Out now in @angew_chem, find out how to give chemistry direction with our comprehensive review on Molecular Ratchets: onlinelibrary.wiley.com/doi/10.1002/an… A brief description in the tread below.

Now online: News & Views on the Article by @enzoolivieri4 @James_Gall_ @AlexBetts95 @Toufic_Mrad @ProfDaveLeigh at @UoMChemistry nature.com/articles/s4416… Synthesis goes uphill by Michele Stasi, Héctor Soria-Carrera & Job Boekhoven @BoekhovenLab nature.com/articles/s4416… ($)

Very happy to share the first article from my postdoc with @leonard_prins, "A Minimalistic Covalent Bond-Forming Chemical Reaction Cycle that Consumes Adenosine Diphosphate". Thanks to our coauthors Tommaso Marchetti (@RealTommyMarch) and Diego Frezzato onlinelibrary.wiley.com/doi/abs/10.100…

Taking inspiration from synthetic biology and using a ratchet mechanism to drive the transformation, chemists have reported a rare instance of a spontaneous, energetically unfavourable reaction powered by a chemical fuel. chemistryworld.com/news/energetic…

@DeanAstumian thanks Dean, appreciate it!

Great to see this longstanding challenge experimentally accomplished! Congratulations!

@MoranLabChem @NatureSynthesis Thanks Joseph!

@James_Gall_ @NatureSynthesis Fantastic work!

Out now in @NatureSynthesis, we drive an endergonic Diels-Alder reaction energetically uphill by chemical fuelling. Reminiscent of anabolism in biology, we hope that an understanding of endergonic synthesis will help expand the chemist's toolbox. nature.com/articles/s4416…

@EPenocchio @enzoolivieri4 @AlexBetts95 @Toufic_Mrad @ProfDaveLeigh Thanks Emanuele, and made all the better with yours and @benjamino_acid's input!

Now online and open access: Article by @enzoolivieri4 @James_Gall_ @AlexBetts95 @Toufic_Mrad @ProfDaveLeigh at @UoMChemistry Endergonic synthesis driven by chemical fuelling nature.com/articles/s4416…