Jan Gerhartz

🤩It's out! Check out our latest paper describing an optimised #CRBN that we used for high-throughput drug screening and developing new chemo-proteomic assays. #HTS #TPD @proxidrugs @IBC2_GU @goetheuni

Online! An engineered cereblon optimized for high throughput screening and molecular glue discovery by Henry Bailey, Jonathan Eisert, Fiona Sorrell @Fi_in_Frankfurt, Ivan Dikic @iDikic2 @DikicLab et al at @goetheuni @IBC2_GU @MPIBP @merckgroup dlvr.it/TGRCyX

Was great to contribute to this story together with @JanGerhartz @dpienkowska9 Ina Dressel & Thomas Geiger from the lab. #CRBN #Interactome #GLUES @CellChemBiol @EnamineGermany @iDikic2 @merckgroup @ibetportugal @MPIbp Animation credit @proxidrugs Paper: authors.elsevier.com/sd/article/S24…

We can now activate p53 Y220C by recruiting BRD4 to it with small molecule TRAP-1. This was a great collaboration with Gray lab and Attardi Lab @Stanford lead from @UniBonn @UniklinikBonn by @dpienkowska9 & @JanGerhartz. biorxiv.org/content/10.110…

Great to have been part of this project with @FKH_Lab with Dominika and @JanGerhartz stellar team. #BonnTPD #HDAC #PROTAC

Excited to share our latest preprint on developing the first selective class IIb HDAC #degraders! Thrilled to see the #TPD community growing in Bonn @RPNowak @c_steinebach ! Huge congrats to first author Shiyang @Vincent_SYZ and the entire team! - go.shr.lc/3LqRQhm

It was a lot of fun to writhe the preview perspective article: “A Double Whammy for KEAP1”. Discover the bivalent mechanism affecting KEAP1 and their implications for future small molecules. #FirstPaperFromTheLab #Science #KEAP1 #Biology #NewPublication sciencedirect.com/science/articl…

We are #hiring! We have an open #postdoctoral position in my group with the focus on structural biology #cryoEM and X-ray crystallography of new #E3 ligases as well as #molecularglue complexes. @UniBonn @IsbBonn nowak-lab.com Please RT!

Very excited to have Thomas Geiger joins the Nowak lab at @UniBonn @UniklinikBonn as a postdoc! Thomas brings experience from the roots of #inducedproximity with his PhD work at @Hausch_lab @TUDarmstadt on degraders and #glues FKBP proteins. Great to have you onboard Thomas!

Great to have Dominika Pieńkowska and Ina Dressel join the Nowak lab! Dominika started her Master's project with us and Ina joined as a lab manager. BelatedTwitter welcome Dominika and Ina! @JanGerhartz #GoTeam #TPD #NewPI @UniBonn @UniklinikBonn @IsbBonn nowak-lab.com

Prof. Radosław P. Nowak hat die neue #Professur für „Immune Engineering and Drug Discovery“ am Institut für #Strukturbiologie des Universitätsklinikums #Bonn (UKB) angetreten. #ukbonn ukbnewsroom.de/experte-fuer-g…

We are happy to announce that our team member Dominic Ferber has received a doctoral scholarship from the @studienstiftung! Great support for his PhD research. Congratulations!

Excited about #TPD and #InducedProximity? So are we, and we are recruiting! #postdoc #technician #NowakLab #Germany @UniBonn @UniklinikBonn @ImmunoSens Please DM or reach us on nowak-lab.com

Holiday gifts arriving early at @UniklinikBonn! Very excited to get it running! #NewPI #Pherastar @BMGLABTECH

I never expected colonies on ALL plates will make me this happy! #NewPI #OnARoll

Very excited to have Jan Gerhartz join the group in the Nowak Lab - @UniBonn @IsbBonn. Jan is a chemist by training, with London startup experience and structural biology in Hagelueken Lab @gha14. Welcome Jan! nowak-lab.com