Janine Brunner

Excited to share a new preprint of the lab! Using native SV2A and cryo-EM we provide the structural basis for tetanus toxin entry into central neurons and reveal the binding mode of the anti-seizure drug Levetiracetam used in the treatment of epilepsy.   biorxiv.org/content/10.110…

Congratulations to first author Gangadhar Eluru, co-authors Steven De Gieter, Stephan Schenck, Annelore Stroobants, Binesh Shrestha, Paul Erbel and Ruslan Efremov. #MISO #CryoEM #StructuralBiology #MembraneProteins #VIB #NatureMethods #BioRender

MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony   Or from a single dish of HEK cell culture for two membrane proteins.   Out in Nature Methods! lnkd.in/gpyBSceg   Great collaboration with Efremov lab.

These findings, through cryo-EM and electrophysiology, have important consequences for TRPM3-targeted drug discovery and therapy.   Great collaboration with the Voets and Vriens labs and CISTIM. Congratulation to first authors Bahar Bazeli, Alexander Shkumatov and Stephan Schenck

Our newest preprint: We discover that chemically different modulators of TRPM3 act on the same binding site and report that mutations in this promiscuous binding pocket can alter the stereoselectivity and invert the functional outcome of ligand binding.   biorxiv.org/content/10.110…

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳rdcu.be/eBbrH Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo

Congrats, this is awesome!

Interactions between TTYH2 and APOE facilitate endosomal lipid transfer TYYH、ついに機能が明かされたか Dutzler groupから、4年越しの続報 nature.com/articles/s4158…

The structural basis of cold sensitivity biorxiv.org/content/10.110… #biorxiv_biophys

Discoveries: SV2A's structure reveals how tetanus neurotoxin and anti-epileptic racetams like Levetiracetam bind, illuminating paths for therapeutic advancements. PMID:40325068, Nat Commun 2025, @NatureComms doi.org/10.1038/s41467… #AI #Pharma #BioMed #RNA #ASHG #ESHG

@BasurajSK @natcomms Thank you Basavraj!

@JanineBrunner2 @natcomms Congratulations Janine and your team 🎊

I am delighted to share our findings on the binding mode of tetanus neurotoxin and the anti-epileptic drug Levetiracetam to SV2A, an essential synaptic vesicle membrane protein of unknown function, now online in @NatComms   nature.com/articles/s4146…

Congrats to first author Stephan Schenck, and collaborators Toon Laeremans @Jansteyaert

We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin. It's a broad call, please apply and share! jobrxiv.org/job/max-delbru…

1/ In my final project as part of the @CorryLab, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations.. biorxiv.org/content/10.110…

Themis and Grb2 form a constitutive structural hub in TCR signaling doi.org/10.1101/2025.0… @DanielleMClancy @SavvidesLab

Native GABAA receptor structures from the human brain! Amazing work! Huge congrats to Ryan Hibbs and his team! nature.com/articles/s4158…

Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling | Nat Struct Mol Biol doi.org/10.1038/s41594…

Cool. I heard microfluidics+cryoEM predicted by Edward Lemke @LemkeLab 10 years ago or so during a seminar discussion @EMBLHeidelberg. Not everyone was convinced so it is exciting to see this is actually possible!

Love this.. 👏

Structures of mammalian membrane proteins from a single cell culture dish! It is a great pleasure to share our latest collaborative work with the @RouslanEfremov lab biorxiv.org/content/10.110… #cryoEM #MembraneProteins #Microfluidics