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Sophie Janssens Lab
74 posts
Sophie Janssens Lab
@JanssensLab
Laboratory for ER stress and Inflammation, VIB-UGent Center for Inflammation Research.
Ghent, Belgium Katılım Şubat 2020
217 Takip Edilen482 Takipçiler
Almost 15 years after our initial observation that IRE1 is specifically active in cDC1s, we finally start understanding why…
Check out the new study from @victor.bosteels, published in @natcomms.nature.com
Paper in press @ rdcu.be/fur4Q
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This process is specific to cDC1s and is only required during homeostatic not immunogenic maturation.
Thanks to @ERC_Research for supporting this work through the ERC-CoG DCRIDDLE. Thanks to @ugent_fge and @InflamResCen for their fantastic support to my team.
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In contrast to most secretory cell types where IRE1 gets activated by accumulation of unfolded proteins in the ER, IRE1 gets activated by cholesterol influx during apoptotic cell engulfment in cDC1s. IRE1-dependent RIDD drives cholesterol efflux during homeostatic DC maturation.
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Sophie Janssens Lab retweetledi
Registration is open for Mucins in Health and Disease! 15–18 June 2026, Ghent - Belgium
All info on: vibconferences.be/events/mucins-…
Travel awards available from @socmucimm and @MucosalImmunol
#Mucins #MucosalImmunology #Microbiome #Inflammation
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@LarsVereecke @MaudeJans @magdalenakolata Congratulations, Lars and Han, and all co-authors! Beautiful work!
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🎉 Super excited to announce that our study "Colibactin-driven colon cancer requires adhesin-mediated epithelial binding" is now published in Nature! Huge congratulations to first authors @MaudeJans and @magdalenakolata for their fantastic work! 1/6🧵🎉
nature.com/articles/s4158…
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Thrilled to present our unpublished work on how dendritic cells decode LNP-embedded antigenic cargo at the @ESGCT meeting in Rome (bit overwhelmed by the amount of people though😱). For all DC and LNP lovers, come find me at 15h3O in Parallel session B.
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@JBoettcherLab @KU_Leuven Thanks a lot, Jan, for a great talk! It was fun to host you in Leuven!
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Everything set up at the @KU_Leuven Irish college for the tumor immunology and immunotherapy research day. Looking forward to for the first time present some of our unpublished work on cDC1-sensing of dying cancer cells.
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@JanssensLab @Victor_Bosteels @InflamResCen Congratulations @JanssensLab @Victor_Bosteels. Great that this is out.
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Very happy that our review in Nat Rev Imm is out! Trying to shed some light on the many knowns and even more unknowns of homeostatic dendritic cell maturation with @Victor_Bosteels @InflamResCen
Nature Rev Immunol@NatRevImmunol
Striking a balance: new perspectives on homeostatic dendritic cell maturation dlvr.it/TDLpt2
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@Victor_Bosteels @JanssensLab Hi Victor, Congratulations! Just read it, so insightful!
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@mariska_simpson Huge congratulations Mariska, Mike and Wayne. Great work!
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I am exceptionally proud of this work. Here we address how the #UPR signal transducer IRE1 is activated by unfolded proteins. This remains an unresolved fundamental question, despite nearly thirty years of research! I hope it is well received by the #ProteinHomeostasis community.
Journal of Cell Biology@JCellBiol
Simpson, Grey, Lencer et al. @BostonChildrens find that IRE1α binds a metastable structural motif in cholera toxin and other proteins that activate the UPR with implications for how binding may be linked to IRE1α activation. hubs.la/Q02rZhbN0 #ProteinHomeostasis
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@inoagrafioti @ERC_Research 🤔 good to know, unfortunately it is still something you get to hear…luckily, we know better😉!
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On international women’s day,as someone that attended more than 500 @ERC_Research interviews in her panel,I can tell you that NO grantee has gotten her grant because she is a woman.I also celebrate today all LS1 women APPLICANTS and all LS1 women PANEL MEMBERS!You are AMAZING!🤩
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@KC_DC_01 @EFIS_Immunology @EurJImmunol @society_belgian @ugent @VIBLifeSciences Congrats, Charlie! Well deserved!
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Very honoured to receive this award from @EFIS_Immunology & @EurJImmunol 🙏 This reflects a big team effort & I’m very grateful to my mentors & team for all help, support & cool science leading to this! Also thanks to @society_belgian for nomination & @ugent @VIBLifeSciences 🥂
EFIS@EFIS_Immunology
Following the recommendation of the Gender & Diversity Task Force, the recipients of the 2023 @EurJImmunol Ita Askonas Prize awarded by EFIS are ...🥁 Dr Muzlifah Haniffa @Muzz_Haniffa Dr Charlotte Scott @KC_DC_01 Congratulations - here’s to the award ceremony at the #ECI2024!
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Super proud of this paper! We show that the thymus is more than a T cell producer, and during type 1 immunity can produce peripheral homing ILC1s! science.org/doi/10.1126/sc…
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Interested in dendritic cell biology and/or IRE1 signaling? Ready for a new challenge in the city of Ghent? If the answer is 2x yes, please check the VIB website for open positions for a PhD student jobso.id/har5 and a postdoc jobso.id/har8 in the @JanssensLab
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So now we finally know why IRE1β behaves as it does: it just needs its partner in crime, AGR2, to calm down.
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AGR2 is a pretty interesting protein, especially upon mutation of H117 to Y: this causes massive inflammatory phenotypes in patients. Turns out that the H117Y mutant is also completely incapable of blocking IRE1β activity!
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Great job by @ClootsEva and Phaedra from the Janssens lab! Happy to see their work out in @embojournal.
A fun and collaborative effort with @VIBEyckermanS and @SavvidesLab.
@VIBLifeSciences @InflamResCen
Time for a thread!
embopress.org/doi/full/10.10…
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