Dr Javier Sánchez Utgés @javierutges.bsky.social

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Dr Javier Sánchez Utgés @javierutges.bsky.social

@JavierUtges

BSc in Genetics at @UABBarcelona MSc in Bioinformatics at @UPFBarcelona PhD in Structural Bioinformatics at @dundeeuni Postdoctoral Research Fellow at @ucl

London, England, UK Katılım Temmuz 2020

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·8 Oca

🎉 Happy new year to everyone! 📢 Kickstarting 2026 by sharing our latest work, now available on #Open #Biology by @RSocPublishing. The title is "Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish ints interaction with the Ser/Thr kinase CK1α".

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Jude Wells@_judewells·2d

I'm 6 months into this fellowship, and it's been brilliant. If you've got ideas at the intersection of AI and science and want to take a shot at making them real then I can't think of a better opportunity. 8 DAYS LEFT TO APPLY TO JOIN COHORT 2. @encode_pillarvc @ARIA_research

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·9 Mar

@xinformatics @gklambauer @IsomorphicLabs @gklambauer, VN-EGNN is a great method, and very precise. However, its redundancy in predictions affects performance evaluation, and could be an issue if duplicate predictions were counted as multiple positives in your calculated success rate and reported performance evaluation!

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·9 Mar

@xinformatics @gklambauer @IsomorphicLabs @xinformatics, your results agree with our benchmark and are likely related to the fact that between c.a. 67% of VN-EGNN predictions are redundant, i.e., are of the same pocket and are in very close proximity, within 5 Å. Redundancy is even higher (75%) for COACH420.

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Günter Klambauer@gklambauer·13 Şub

For Pocket Identification @IsomorphicLabs are so far behind SOTA that they have to compare against a method from 2018, wow! Please compare against VN-EGNN or ConGLUDe: arxiv.org/abs/2601.09693 link.springer.com/article/10.118…

Max Jaderberg@maxjaderberg

The Iso team has cooked something incredible: our new technical report unveils the latest results from our drug design engine, the IsoDDE, progressing far beyond AlphaFold 3. This breaks new ground compared to AF and other similar methods by a significant degree across all key benchmarks. 1/7

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·9 Mar

@gklambauer @IsomorphicLabs Also, despite being 8 years old, #P2Rank is still #SOTA, particularly when using conservation as an extra feature. Outperforming P2Rank+Cons would further highlight #IsoDDE's already impressive capabilities, @IsomorphicLabs! For more details, check: tinyurl.com/JSU-LBScomp!

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·9 Mar

@gklambauer @IsomorphicLabs @gklambauer, this benchmark evaluates prediction at the residue level. It would be rather hard to compare against VN-EGNN, given that your method does not report residue-level ligandability scores or probabilities, or even the residues that form the pockets, for that matter.

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·3 Şub

Thank you again for being part of this. #Together, we really can make a difference! ✨ #CancerResearchUK #CRUK #Fundraising #CharityChallenge #PushUpChallenge #FitnessForGood #TogetherWeCan #CancerAwareness #Community #Health

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·3 Şub

My #CRUK page is still open, so donations are still welcome if you would like to help push the total a little further: fundraise.cancerresearchuk.org/page/javiers-g… 🔗 A couple of quick notes: ✅ All funds go directly to CRUK ✅ If you select 'Gift Aid', an extra 25% is added at no extra cost 🎁

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·3 Şub

Hi, everyone. I did it! ✅ 💪 #Challenge complete: 31 days of 100 push-ups a day - finished! 🔥 I started this as a small personal commitment with a big purpose: to support @CRUKScotland and help fund vital work in #cancer #research. 🎗️

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·16 Oca

Thank you for your support - and for helping raise awareness. It really means a lot. 🙏 ✨ #CancerResearchUK #CRUK #Fundraising #CharityChallenge #PushUpChallenge #FitnessForGood #GiveWhatYouCan #TogetherWeCan #CancerAwareness #Health #Community

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·16 Oca

If you would like to learn more, follow my progress, or donate in just a few clicks, here is my CRUK giving page: 👉 tinyurl.com/JSU-CRUK A couple of quick notes: ✅ All funds go directly to #CRUK. ✅ If you select 'Gift Aid', an extra 25% is added at no extra cost to you. 🎁

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·16 Oca

Hi! 👋 I wanted to share a small personal #challenge with a big #purpose: for the past 15 days I have been doing 100 push-ups a day, and I am committed to keep going for the next 16 days too. This is a @TalkCancer_CRUK initiative to help fund work in #cancer #research. 🎗️💪 🔥

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·8 Oca

@gjbarton @gpsapkota @mrcppu @dundeeuni @GoogleDeepMind 🎙️ Thanks to everyone that helped on this project: Nicola Wood, Thomas Macartney, @mrcppu Reagents and Services, Dundee Uni DTS, @bartongrp, @Jalview team, James Abbot and also Martin Steinegger and his team for the excellent #ColabFold implementation!

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·8 Oca

@gjbarton @gpsapkota @mrcppu @dundeeuni @GoogleDeepMind 🔑 Our findings demonstrate the #utility of our #computational #methods to uncover #functional #residues on proteins based on fragment-binding sites. 📜 PAPER: doi.org/10.1098/rsob.2… 🔗 FRAGSYS: doi.org/10.1038/s42003…

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Dr Javier Sánchez Utgés @javierutges.bsky.social@JavierUtges·8 Oca

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@encode_pillarvc @ARIA_research @xinformatics @gklambauer @IsomorphicLabs @CRUKScotland @TalkCancer_CRUK @gjbarton