Jacek Jemielity

New Cover from Ella Maru Studio! Advanced mRNA Cap✊ This paper describes AvantCap - a chemical modification of messenger RNA 5' end that confers superior translational properties to mRNA. The design of AvantCap was inspired by a naturally occuring modification of mRNA cap - so called m6Am mark. @JoannaK_UW, @JemielityLab, @JeffMugridge from @UniWarszawski and @UDelaware found that mRNAs carrying AvantCap produce more protein in vivo than reference mRNAs, while mRNAs encoding tumor antigens show superior activity in therapeutic settings as anticancer vaccines. Therefore, AvantCap has tremendous potential to advance the therapeutic mRNA field. Learn more: pubs.acs.org/doi/10.1021/ja… #RNAbiology #mRNA #RNA #vaccines #molecular_biology #ella_maru_studio #journalcover #phdlife #phd #sciencegirl #scicomm #womaninscience #medicalartist #sciencegirl #biology #chemistry #sciart

Biology-inspired modification of the 5' end of mRNA with high therapeutic potential. Probably the most important research in my life so far.

@SteDziembowski @adamgendzwill Jak widzisz ambicje są raczej umiarkowane :) Ale dzięki, będę pamiętał

Pełen protokół głosowania indykacyjnego #WyboryRektoraUW. @adamgendzwill @JemielityLab - czemu nie mówiliście że macie ambicje rektorskie? Mielibyście moje głosy!

A good home for our joint research! Thank you again for the exciting collaboration! @NatureChemistry @BaranLabReads @UniWarszawski @JoannaK_UW

A summary of our research on therapeutic mRNA published in Accounts of Chemical Research. Topics very timely lately :). Congratulations to @kkariko and @WeissmanLab !!! pubs.acs.org/doi/10.1021/ac… @UniWarszawski @JoannaK_UW

Thank you @JeffMugridge for your visit and sharing with us the great science!

Proud of exploRNA team

Thanks Phil and the team for a great collaboration! @JoannaK_UW @BaranLabReads

Today in @ChemRxiv (bit.ly/3ic6OMI): Democratized access to stereo pure thioisosteres of life's building blocks with promising translational potential in medicine. New reagents and a completely different strategy coupled to some amazing collaborators enabled this study.

2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion NAR academic.oup.com/nar/advance-ar…

The recruitment is open one more week. Don't forget to apply!

We published in JOC a procedure for modifying commercially available building blocks for synthesis of oligonucleotides. The method provides quick access to tools for studying post-transcriptional modification of RNA. @JoannaK_UW, @UniWarszawski @JOC_OL pubs.acs.org/doi/10.1021/ac…

We are looking for two post-docs to work on an exciting project aimed at finding new ways to improve therapeutic mRNAs! If you would like to join our chembiobiochem.com group, please apply. euraxess.ec.europa.eu/jobs/814952 Retweets appreciated. @PostdocP @PostdocJobs @JemielityLab

The first nucleosides for the SuFex reaction – useful tools in chemical biology and drug discovery published in #OL by @JemielityLab. Learn more here: pubs.acs.org/doi/10.1021/ac…

Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties (Jemielity, Kowalska et al.) @JemielityLab @JoannaK_UW #OpenAccess onlinelibrary.wiley.com/doi/10.1002/ch…

We are looking for post-docs interested in working on novel therapeutically relevant mRNA modifications in our chembiobiochem.com group. Retweets appreciated! cent.uw.edu.pl/en/career/post…

We have #RecentlyPublished an #aricle by Dorota Kubacka and her associates: #Substrate-Based Design of Cytosolic Nucleotidase IIIB #Inhibitors and #Structural Insights into Inhibition Mechanism Full text is available at: 👉mdpi.com/1424-8247/15/5… @UniWarszawski @MPI_Biochem

#MDPIPharmaceutics 📗 "Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation" by Radoslaw Wojcik et al. Full paper at：mdpi.com/1999-4923/13/1…

Fundacja na rzecz Nauki Polskiej i Nagrody FNP mają 30 lat! Gratulujemy tegorocznym laureatom z @PAN_akademia i @UniWarszawski i kontynuujemy naszą misję wspierania najlepszej nauki w Polsce. #30latFNP, #NagrodyFNP, szczegóły na stronie:👉bit.ly/3IwML4j

Our method for efficient double labeling of mRNA and its diverse in vitro and in vivo applications published in Nucleic Acids Research. I am very proud of this work. academic.oup.com/nar/advance-ar…