John D. Helmann

Curious about organelle biogenesis in bacteria 🦠🔬Check out our review on bacterial organelles and their role in iron physiology @MolMicroEditors doi.org/10.1111/mmi.15…

🥳A tuneable minimal cell membrane reveals that two lipid species suffice for life: nature.com/articles/s4146…. We chemically minimized the membrane of the Minimal Cell...they survived, but with some interesting shapes, like this 'Death Star' phenotype @Ijustice555 @JCVenterInst

I am pleased to announce that our paper describing the role of NusG-dependent RNA polymerase pausing on the function of 5 riboswitches is now published in NAR. academic.oup.com/nar/advance-ar…

A new study in PNAS explores the connection between methionines and copper, with a focus on CueO. A collaboration between @lcb_officiel and @BIP8_Marseille 🍾🍾 Methionine-rich domains emerge as facilitators of copper recruitment in detoxification systems pubmed.ncbi.nlm.nih.gov/39378088/

The evolution and functional significance of the programmed ribosomal frameshift in prfB biorxiv.org/cgi/content/sh… #biorxiv_micrbio

🧵 Exciting new findings on bacterial stress response regulation, driven by small proteins (≤50 amino acids). Big shoutout to the amazing team behind this work led by @vsangeev. Read the full study here: biorxiv.org/content/10.110…

Read the new story of @WarnekeRobert on coenzyme A biosynthesis in Bacillus subtilis and the identification of a novel metabolite, cysteinopantetheine! Excellent collaboration with @c_elfmann @IFeussner and teams! @mbiojournal @uniGoettingen #subtiwiki journals.asm.org/doi/10.1128/mb…

Our new paper out in @PLOSPathogens today: dx.plos.org/10.1371/journa… We find that resistance/tolerance to antimicrobial peptides is slightly more complex and dynamic than your "average" antibiotic resistance. Nice work by @AndyMurtha et al.!

New in JB: Kochanowsky, Vedantam et al. show that Clostridioides difficile deploys a superoxide reductase to resist the effects of oxygen. journals.asm.org/doi/10.1128/jb… @ASMicrobiology @JBacteriology

We have a new paper out! Deeply branching Bacillota species exhibit atypical Gram-negative staining | Microbiology Spectrum journals.asm.org/doi/10.1128/sp…

Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS @NatureComms from @HamoenLeendert with @HenrikStrahl @KursadTurgay nature.com/articles/s4146…

Very excited that this collaborative project is now published. This work was championed by Dr. Yu Tang @Tangyu0901 (Tongji University School of Medicine) and started during a visit to my lab. academic.oup.com/nar/article/do… 1/N

onlinelibrary.wiley.com/doi/10.1111/mm… @BlastMeetings @MolMicroEditors

I’ve felt more than lucky to be able to tour around the US! Thanks to @JohnHelmann and his whole lab for being so welcoming and talking some great science (and not science!) with me this week 🧬👩‍🔬

Finally published! Check out the final version of our paper describing the discovery of methylolanthanin, a lanthanide metallophore secreted by methylotrophs! pnas.org/doi/epub/10.10…

The long-awaited structure of Bacillus MntR bound to DNA! While structures of iron-sensing DtxR family members bound to DNA have been known for decades, the DNA complexes of manganese sensors have long eluded structure elucidation. Cryo-EM to the rescue!

N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum biorxiv.org/cgi/content/sh… #biorxiv_micrbio

A huge step in understanding the biological role of flotillin and membrane microdomains. Led by our very own Marta Ukleja 🇵🇱🙌🙌🙌 with the help of @CavaLab_MIMS, @mateus_lab and (twitterless) Ana Eulalio :-). @CaixaResearch funding. rdcu.be/dMWvC

Excited to see this detailed view of MntR-oligomerization that is key for Mn-activated transcription in B. subtilis! Work led by Shivani Ahuja and Arthur Glasfeld. Structural basis for transcription activation through cooperative recruitment of MntR biorxiv.org/content/10.110…

A family of DNA glycosylases in bacteria that repairs interstrand DNA crosslinks, protects against acid, and is involved in infection. New work from @DKunk and @YujuanCai in collaboration with @BFEichman @PNASNews pnas.org/doi/10.1073/pn…