Jon Emery

Our paper estimating the infectiousness of subclinical tuberculosis and its contribution to transmission has now been published in elife. elifesciences.org/articles/82469

@dopapus @tomayates @petermacp @LeoMarti_EpiTB @petedodd24 @Rein_Houben I'd also bear in mind that the sample sizes available led to fairly wide uncertainty intervals. I think the important conclusion is that our lower bound suggests that the infectiousness of subclinical TB is unlikely to be negligible.

@dopapus @tomayates @petermacp @LeoMarti_EpiTB @petedodd24 @Rein_Houben Thanks all for reading and glad it's interesting! @dopapus we used crude ORs in the preprint but haven't seen any material variation when adjusting for age and sex. This is something we could look to include as a sensitivity though.

Exciting to see this out - need to read closely!

@tomayates @petedodd24 @Rein_Houben @petermacp Do let me know if you have any further thoughts - happy to chat anytime.

@tomayates @petedodd24 @Rein_Houben @petermacp I also agree with you about the limitation of using households with no TB cases. A background rate of infection is crucial for estimating relative infectiousness and I'd hope future studies would include some random sampling to improve this measure.

Very much enjoyed reading this preprint by @JonCEmery @petedodd24 @Rein_Houben and colleagues Ambitious and exciting analysis Here are my initial thoughts ... [1/n]

@petedodd24 @b_frascella @kc_horton @FvLScience @Marks1Guy @alexsrichards @nabilashaikhs @richardwhite321 @Rein_Houben @drhaivnguyen

@petedodd24 @b_frascella @kc_horton @FvLScience @Marks1Guy @alexsrichards @nabilashaikhs @richardwhite321 @Rein_Houben

Our preprint estimating the infectiousness of subclinical tuberculosis and its contribution to transmission is now out on medRxiv. medrxiv.org/content/10.110… NOT YET PEER REVIEWED

@tomayates @Rein_Houben @BolsoverE @dopapus @petedodd24 @ryandinkele @CMLWilliamsUK Great timing Tom. Yes, fingers crossed will be on MedRxiv today or tomorrow. Hope you're keeping well.

@Rein_Houben @JonCEmery @BolsoverE @dopapus @petedodd24 @ryandinkele @CMLWilliamsUK MedRxiv?

What is the best empiric data we have on the relative infectiousness of pauci/asymptomatic pulmonary TB? Last I looked, this was an unsolved question. @Rein_Houben @JonCEmery @BolsoverE @dopapus @petedodd24

A huge thanks to excellent collaborators @alexsrichards, Katie Dale, @CFMcQuaid, @richardwhite321, @justin_denholm and @Rein_Houben

The population with a viable Mtb infection may be markedly smaller than generally assumed - new modelling study of Mtb self-clearance out today in Proceedings of the Royal Society B: royalsocietypublishing.org/doi/10.1098/rs…

Are you interested in Subclinical TB and what it means for #AdvancingPrevention? Don't know what all the fuss is about? Have your say at menti.com/pe5do8z9mm @StopTB_ETT @Rein_Houben @TomScriba @hanifesmail_tb @JonCEmery @CIDRI_Africa @UnionConference @LSHTM_TB @UCTIDM @FINDdx