Jonathan Huff

You can buy each piece of the SIP mask valve separately and in bulk, and save a fair bit. Especially important if you use your SIP a lot or need to supply a covid safer event. More links in the 🧵

There are probably still a few typos... I have 2.5 hours to catch them and turn this in. Not bad for four hours. The extra link has been removed because the project isn't finished, but it should be done by the time I present this. docs.google.com/presentation/d…

@DonEford Excellent points and I love saying directly that their influence should be disregarded since they left and never had the qualities necessary for their jobs let alone for their harmful recommendations regarding vaccine policy

I'm still trying to raise money, and I've already raised $200 of this week's goal. x.com/DonEford/statu…

@ghhughes @LazarusLong13 Oh no! One of the most important and innovative masks... does that mean Redimask is no more?

Alliant biotech is giving away their remaining 20 pallets of size large redimasks. For local pickup by the pallet load only. reddit.com/r/Masks4All/s/… They haven't yet specified whether all 20 pallets must be picked up together or not, but I assume, at the very least, that that would be their preference.

This is how I add two exhalation valves to my KN95 ZimiAir respirators. ZimiAir sells a tool for cutting 28mm holes and you can reuse the valves from masks sold with single valves like the ZM8210F. zimiair.com/product/zm8210…

@oldfshndanne @ghhughes @LazarusLong13 @michael_hoerger The moldex Airwave M4620 is designed to be reused several times, but is a disposable respirator. The build and the filter performance definitely inspire confidence. So it just has to do with whether it fits you. Probably it does!

@JonKHuff @ghhughes @LazarusLong13 @michael_hoerger This is what I'm worried about, but I really want to try it. Does it have replaceable filters?

I am stunned at the breathability test results for this Moldex Airwave N95. I've been testing various masks to see how breathable they are using a testing machine, and the Airwave was so breathable I had to run the test again with another sample just to make sure the test results were real. It is massively more breathable than other good quality N95s I've tested. --- Lower pressure drop scores mean it takes less suction to draw air through the mask. So lower scores are better.

💊🧵 Thoughts on Xocova/Ensitrelvir, the drug that everyone is talking about today after Nature recently described it as “a pill that can prevent COVID after exposure to infected people.” For starters, none of this data is new. @ShionogiUS published topline data for SCORPIO-PEP, the trial showing that Xocova is beneficial in post-exposure prophylaxis, in March of 2025: shionogi.com/us/en/news/202… Yesterday, the full peer-reviewed results from the SCORPIO-PEP trial were published in the New England Journal of Medicine, which is why everyone is suddenly talking about them: nejm.org/doi/full/10.10… After that data was released in March 2025, Shionogi then submitted applications with the Japanese government and with the US FDA for the indication of post-exposure prophylaxis: shionogi.com/us/en/news/202… In Japan, this drug is not new at all. It has been approved for the treatment of COVID-19 since 2022. And, 2 months ago in March 2026, Japan did indeed issue approval for that indication of post-exposure prophylaxis: shionogi.com/global/en/news… For @US_FDA , the decision date that they have set is coming up next month, on June 16th. In my view, we’re going to need all the help that we can get to push this approval through, because the FDA offices that will need to issue an approval are currently in complete turmoil: • Earlier this week, Politico announced that FDA commissioner Makary is resigning, and will be replaced by acting commissioner Kyle Diamantas: politico.com/news/2026/05/1… • The FDA’s Center for Drug Evaluation and Research (CDER) is now led by Tracy Beth Høeg, one of the worst anti-science hacks that this administration has to offer. Just last week, it was widely reported that she personally got involved against Sanofi’s type 1 diabetes drug in a disagreement with staff: biospace.com/fda/sanofi-req… • Within CDER, the Office of Infectious Diseases (which Xocova approval goes through) currently has no director - Adam Sherwat left the FDA last month: statnews.com/2026/03/18/fda… If you would like to help urge the FDA to approve Xocova, there is an active petition you can sign here: change.org/p/urge-the-fda… Now, what exactly is Xocova, and what is it capable of? When you strip away the flashy headline from Nature, Xocova is the same class of drug as Paxlovid - a 3CL protease inhibitor. It’s just essentially a “2nd generation” version. It’s a very encouraging step up from Paxlovid, because it’s very obviously a bit more potent, it comes with slightly less side effects, and it also has less drug interactions. That’s all great, and those advantages highlight why it’s important to get this on the market. It’s going to be good for lowering viral load during an acute infection, if taken within the first couple days of symptoms, but probably still not very helpful at preventing long-term damage or Long COVID. Just like Paxlovid, it’s going to be an important part of polytherapy for Long COVID driven by viral persistence. The issue there is that you need a longer course of these antivirals than most physicians are willing to prescribe, and most insurance companies are willing to cover. And it’s not effective as a monotherapy, you need to pair these oral antivirals with other therapies for better coverage (eg. monoclonal antibodies and Novavax, and potentially even a 2nd antiviral like Remdesivir) And, indeed, as Nature points out, it does appear to be somewhat beneficial for post-exposure prophylaxis, reducing COVID incidence from 9% to 2.9%. This initial data is encouraging that Xocova could potentially be another Swiss cheese layer / tool in our toolbox, but not a game-changing silver bullet. Notably, nobody should really be expecting to use or rely on Xocova in a way that they wouldn’t be open to using or relying on Paxlovid in the present.

@NukitToBeSure Yeah. People have a point about the exploitative wellness sellers for ME. But ME sufferers are grasping at straws. Can't act up like AIDS because they're energy debilitated. Funding is a joke. Straws is basically all there is to grasp. 😓

Uh 90% of being smart is knowing what you are dumb at and I'm *really* ignorant when it comes to ME and related issues so normally stay well clear and stick to engineering. I totally screwed this one up and did not realize how the context of ME changed things. Post deleted with sincere apologies for unhelpful take.

@Nature Sign the petition x.com/moreisdifferen…

We can get a better antiviral (Ensitrelvir) than Paxlovid for treating acute covid and preventing covid! Its approved in Japan and could really help if/when someone gets COVID. Let's go write the FDA!

treasure

I’d like to formally apologize to the Magic the Gathering community for what people are going to do with this new deck I created. The goblins have taken over and I’m afraid it’s too late to stop them now, may gob have mercy on your souls.

“If Hanatavirus was airborne, wouldn’t they just say it?” No because that would mean governments and businesses would be liable for clean indoor air. It will be expensive to implement and people would have power over institutions and corporations. It’s the COVID playbook again.

No app, no AI, no “smart” anything to fail. No planned obsolescence or e-waste. Heavy steel Buy-It-For-Life construction. Repair it with a screwdriver and your local PC parts store. Uses just 14.5 Watts of power. Whisper quiet (39dB) Takes any MERV 13 1x20x25 HVAC filter.

An actual real true story. Doctors told her that her symptoms were anxiety. Within 24 hours she was in critical condition in intensive care.

🚨📢 Call to action! Sign this petition to urge the FDA to approve @ShionogiUS’s Xocova, a 2nd generation COVID-19 antiviral that will give us prophylaxis and treatment options beyond Paxlovid. A decision date is currently set for June 16th, and we’re going to need all the help that we can get to push this approval through, because the FDA offices that will need to issue an approval are currently in complete turmoil: • Just today, Politico announced that FDA commissioner Makary is resigning, and will be replaced by acting commissioner Kyle Diamantas: politico.com/news/2026/05/1… • The FDA’s Center for Drug Evaluation and Research (CDER) is now led by Tracy Beth Høeg, one of the worst anti-science hacks that this administration has to offer. Just last week, it was widely reported that she personally got involved against Sanofi’s type 1 diabetes drug in a disagreement with staff: biospace.com/fda/sanofi-req… • Within CDER, the Office of Infectious Diseases (which Xocova approval goes through) currently has no director - Adam Sherwat left the FDA last month: statnews.com/2026/03/18/fda…

@ashleygjovik ya’ll pls donate gofundme.com/f/ashley-gjovi…

Today from 9am-5pm, is my first Rule 30(b)(6) deposition of Apple Inc. There is a second session on Thursday as well. I get to interrogate Apple the corporation with up to 7hrs of recorded testimony by Apple each day. Please consider donating to cover the Court Reporter fees. 🙏

@O_h_G_o_s_h @suchnerve Zimi comes in XXS, XS, S, M, L (Zimi 8210) and XL. I'd look at the small, or maybe a medium. You can buy just one mask to try out, and the earloop and headloop masks tend to pass formal fit tests.

@suchnerve what would you recommend for a smaller one? i got a little head

Hantavirus discourse is prompting me to reiterate that I have never found a more comfortable 😷 than the Zimi Air 8210, and mind you I’m both a chronic severe migraine haver and autistic (so doubly sensitive to anything touching my head)