Jesse Patterson

Very happy to share Brian and Ingred's latest work in the lab identifying two unique subclasses of neutrophils that arise after tissue injury. Neutrophils in trauma and cancer are getting more and more complex! Contribute to local DNA Damage for sure! journals.lww.com/jtrauma/Abstra…

Check out our latest paper in @FrontMolBioSci ! Congrats to @yiwenkong1 and the rest of the authors! 🥳

New Research: MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach frontiersin.org/articles/10.33… #MolBioSci

This Week’s Southwest Sip Award goes to Ms. Patterson! Thanks for Protecting the Pack!

Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill #CancerCells of Disparate Origins Independently of Androgen Receptor Signaling, by @LabYaffe et al. bit.ly/3HXCJuZ @MIT

Check out our latest paper in @CR_AACR! Not only did it get published - but we also scored the cover pic for this issue (😎), which shows pHH3 staining in patient-derived xenograft samples. Congrats to @Jpatterson____ and the boss @mbyaffe for this amazing body of work!! 🥳

Truly excited that our collaboration with @CantleyLab and @LabYaffe, led by the mighty Jared Johnson and the unstoppable @Tomer_M_Yaron, to map substrate motifs for the Ser/Thr kinome is now out! Literally a project that spanned decades. nature.com/articles/s4158…

Dr. @mbyaffe out of @MITBiology led a study that reported that onvansertib and #abiraterone combination enhanced mitotic arrest and inhibited tumor cell growth compared to either agent alone in a xenograft model of #ProstateCancer. @CR_AACR @LabYaffe 📑 bit.ly/3Vhv12u

I am thrilled to share our newest preprint, in which we describe how Jnk and Erk act as pro-senescence pathways after DNA damage! This work represents a big chunk of my PhD project in @MITdeptofBE, and I am excited to share it with you all (a 🧵) (1/21) biorxiv.org/content/10.110…

biorxiv.org/content/10.110… Just presented our latest work from Tatiana Netterfield in our lab on the roles of JNK and Erk in DNA damage-induced cell senescence at the FASEB Protein Kinases Meeting in Nova Scotia. Kudos to Tatiana and Gerry Ostheimer!

PREPRINT ALERT 🚨🚨🚨 Check out our latest work on biorxiv! A quick TL;DR of this work 🧵biorxiv.org/content/10.110…

Joint effort with @AtishChoudhury @DanaFarber_GU, Phil Saylor @MGHCancerCenter, and @CardiffOncology, correlatives with Balk and Yaffe labs funded by @kochinstitute Bridge grant.

Specialized nanoparticles can deliver the relevant siRNAs in vivo which resulted in prolonged survival. @LabYaffe nature.com/articles/s4146…

An awesome Yaffe Lab paper came out in Nature Communications! Take p53 mutant cancer cells, knock down MK2 and they are hypersensitive to DNA damage. Kong et al found that silencing the NER pathway gene XPA is the icing on the cake and enhances tumor cell killing dramatically.