Prostate Cell News

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Investigators identified CXCR2 as a potential therapeutic target linking metabolic reprogramming and immune suppression in neuroendocrine #ProstateCancer. 🎯 Targeting the IL-8/CXCR2 axis may support further translational and clinical investigation of CXCR2-directed therapies. @jitcancer | bit.ly/4fLntkk

Investigators identified ZNF263 as a transcriptional repressor that silences MHC-I by recruiting nucleosome-remodeling and deacetylase to the STAT1 promoter, reducing STAT1 and MHC-I expression, representing a therapeutic target for #ProstateCancer immunotherapy. 🤫 @PNASNews | bit.ly/4furued

Scientists identified new therapeutic agents for prostate cancer and their potential molecular mechanisms of action, which will provide new insights into the treatment and prognosis of PCa. 💊 Learn more 👉 bit.ly/3RhVqRD

The authors highlight that PSMA-targeting agents incorporate the O-(carboxymethyl)-L-tyrosine scaffold, a versatile linker that enhances binding affinity and optimizes pharmacokinetics. 💊 👉 bit.ly/4pDOBGp

This study demonstrated that NRF2/xCT-mediated residual glutathione redox buffering functions as an adaptive survival mechanism following ASCT2 inhibition and provide a mechanistic rationale for combined targeting of ASCT2 and xCT to overcome redox-adaptive resistance in #ProstateCancer. @CR_AACR | bit.ly/4b01xRa

Investigators with Xiaoju Wang at @UMich demonstrated continued dependency on ERG in metastatic #ProstateCancer and identified a druggable pocket within its N-terminal Pointed domain. 💊 @PNASNews | bit.ly/4fNn9CR

Investigators suggest that CDC20 contributes to prostate cancer progression, at least in part, through a c-MYC-associated PI3K-AKT signaling axis and support its potential relevance for prognostic assessment and therapeutic targeting. 🔬 bit.ly/4frmJAK

In this @iScience_CP article, scientists identify key prognostic genes in #ProstateCancer and to investigate their biological functions and underlying molecular mechanisms. bit.ly/4yp2JaN

Researchers identify mangosteen-derived xanthones that trigger degradation of androgen receptor and AR-V7 through BiP engagement in #ProstateCancer cells. ▶️ bit.ly/4aRXqGM

Researchers identified the lncRNA HUDRPC as a driver of docetaxel resistance in prostate cancer, suppressing ferroptosis through the DDX5–DDIT3 signaling axis. Read more about it here: ▶️ bit.ly/45356T2

Scientists identify a SETDB1–RhoB epigenetic axis that drives epithelial–mesenchymal transition and metastatic progression in #ProstateCancer. 🔖 go.nature.com/44km7rK

In the following study, researchers identify a METTL5–IRF7–DNA2 signaling axis that links rRNA methylation to mitochondrial homeostasis, driving #ProstateCancer progression and revealing a promising therapeutic target. Learn more via @oncogenejournal 🔖 go.nature.com/4pr7nRy

Novel #immunotherapy approaches such as T cell-engager therapies, CD40 agonists, and HSV-TK gene therapy have shown early promise for the treatment of #ProstateCancer. Read the review from Drs. Dallos, Gaffney, and @UrologyMSK collaborators. 📖 🔗 go.nature.com/4vRA5x7

🆕 New in @oncogenejournal! @universityofky researchers including Dr. Ka-wing Fong define a SETDB1-RhoB #epigenetic pathway that promotes #EMT and metastatic progression in #ProstateCancer and may be therapeutically targeted in advanced disease. 🔓 go.nature.com/44km7rK #OpenAccess

This investigation uncovered a novel lactic acid-fueled metabolic-#epigenetic axis that promotes the H3K4me3-mediated PLOD1 upregulation, consequently fostering #ProstateCancer aggressiveness and unveiling a therapeutic vulnerability. 🔗 go.nature.com/4aGSF2y

In this study, researchers designed and synthesized a novel series of dual BRD4/AKT inhibitors. 🧪 Compound 21d modulated key downstream effectors of both AKT1 and BRD4, leading to suppression of #mCRPC cell proliferation, migration, and colony formation. bit.ly/3R4l3VM

Sun Yat-sen University researchers utilized a cysteine-based, GSH-responsive polymer (Cys8E) to deliver a broad-spectrum antitumor agent CBL0137. 📚 bit.ly/4aGX1Xr Exploiting high GSH levels in #ProstateCancer cells, the resulting CBL0137-loaded #nanoparticles achieved targeted and efficient intracellular delivery and enhanced tumor-killing efficacy.

New work from the lab of Dr. Qianben Wang at @DukeMedSchool demonstrates a novel #RNAEditing approach that helps “cold” tumours become more visible to the immune system and respond better to immunotherapy. 🔬 Read the @natBME study: go.nature.com/3TdzcR2

Interested in mechanisms of resistance to androgen deprivation therapy in #ProstateCancer? 🤔 This review summarizes the mechanisms, biomarkers, and emerging therapies for treatment-resistant prostate cancer driven by androgen receptor signaling. Learn more: bit.ly/44CA1Ft

Interested in the #glycobiology of prostate cancer? 🤔 This review from the lab of Dr. Jennifer Munkley (@MunkleyLab) highlights how altered glycosylation drives prostate cancer progression and could provide new biomarkers and therapeutic targets. Learn more: go.nature.com/4oVUL4B