Prostate Cell News

Prostate Cell News focuses on recent scientific journal articles covering prostate cell biology, cancer research, and related disease models. If you want to keep up with recent scientific discoveries in this field, then subscribe to receive free email newsletters delivered straight to your inbox. 📥 bit.ly/4kkWMEu

There are a number of studies that suggest the RAF-MEK-ERK-RSK cascade, a major #Oncogenic pathway, is activated in #ProstateCancer and this increases as the disease progresses. 🥼 Dr. @AdamSharpMedOnc and @ICR_London collaborators discuss. 🗣️ 🔗 go.nature.com/4dG7hRv

New in @jitcancer! Targeting LGALS9 enhances DC-mediated CD8+ T cell immunity and synergistically augments the therapeutic efficacy of tumor vaccines, representing a promising immunotherapeutic strategy for #ProstateCancer. 🎯 🔗 bit.ly/3PE3dIm

The microbiome across the #prostate disease continuum. 🦠🪲 The authors propose a framework for the gut–urinary–prostatic axis and delineate when microbial and metabolite signaling meaningfully conditions prostate disease biology, and when it does not. go.nature.com/4woOulg

A new study shows that ATM-deficient #ProstateCancer cells are highly sensitive to PARG inhibition, revealing a promising synthetic lethal therapy strategy for advanced prostate cancer. 🔬 Learn more: bit.ly/3OOrrQ0

📢 New in @oncogenejournal! Researchers led by Dr. William Ricke at @UWMadPharmacy have shown that the RNA-binding protein DDX3X recognizes RNA G-quadruplex structures in #AndrogenReceptor (AR) mRNA to regulate AR signaling in treatment-resistant #ProstateCancer. Learn more: go.nature.com/4thy3UY

A new study from the lab of Dr. Andrew Goldstein (@ASGoldstein6) at @UCLA demonstrates that OGDHL promotes #ProstateCancer growth and lineage plasticity by supporting nucleotide metabolism and is associated with neuroendocrine differentiation. 🗒️ Read the study: bit.ly/4f9APbk

A new study led by Dr. K. C. Balaji at @UF_Urology suggests that newer MYC/MAX inhibitors more effectively suppress #ProstateCancer cell growth than earlier versions, supporting their potential as improved cancer therapies. 📄 Read the paper: bit.ly/4cPZZdQ

New in @cddpress! 🤩 Nanchang University scientists reveal that the deubiquitinating enzyme USP13 is up-regulated in #prostate cancer (PCa) tissues and correlates with PCa progression. 👣 Follow the link: go.nature.com/4mYFkrb

This @PNAS study demonstrates that reduced expression of UFM1-ligase 1 is commonly observed in #ProstateCancer and correlates with elevated chromosomal instability rates. 🧬 📖 Give it a read: bit.ly/4cT2pa7

Join us in congratulating @uthsc's Dr. Ramesh Narayanan, who was awarded a renewal grant of $2.26 million to support his research in treating drug-resistant #ProstateCancer. 🥳 📰 Learn about Dr. Narayanan's work: bit.ly/3QFisRA

Collaborators with Drs. Strynadka, Andersen, and Sadar leveraged a library of androgen receptor (AR)-TAD inhibitors using cultured #ProstateCancer cells Alterations in the chemical scaffold impacted selectivity and potency within the AR-transcriptome. go.nature.com/42mnogZ

Wilms’ tumor 1-associating protein (WTAP) plays a key role in enzalutamide resistance (ENZR) development of #ProstateCancer cells, scientists reported. 🎯 Check it out in @cgtnature! 📚 🔗 go.nature.com/4uiCMXE

Researchers examine the role of miR-16-5p in human #prostate cell lines and benign prostatic hyperplasia (BPH) tissues. 🔬 Results suggest that miR-16-5p warrants further investigation as a regulator that may help inhibit BPH. 💡 go.nature.com/3QkTh6R | @SciReports

This study identifies Lamin B2 as an #Oncogenic driver in #ProstateCancer, demonstrating that its expression promotes tumor growth and epithelial-mesenchymal transition through the activation of the Wnt/β-catenin pathway. 🔎 📚 Abstract: bit.ly/4cJxZHg

Researchers suggest that tRF-3017b may contribute to #prostate cancer progression by regulating tumor proliferation and immune modulation in vitro, particularly through the cytokine-mediated STAT3 signaling axis. 🧫 📚 Read their findings: go.nature.com/4sVShU9

🆕 New in @CD_AACR! Analysis of 319 spatial assays from 51 cases revealed gene-expression features and novel structural insights defining the shift from precancer to invasive disease. This work was led by Dr. Li Ding's team at @WashU. 📖 bit.ly/4vFNDMA

💭 Koç University scientists suggest that targeting Nicotinamide N-Methyltransferase (NNMT) and the pathways it affects, such as TGFβ, offers a viable approach for addressing taxane-resistant #ProstateCancer. 🔗 Learn more in their @cddpress article: go.nature.com/3QlcpS1

Investigators revealed a novel phagocytosis-mediated, paracrine mechanism of enzalutamide resistance orchestrated by androgen receptor-positive tumor-associated #macrophages. 💊 🔓 Read the full article: bit.ly/41FMjM6

Presented in @cddpress, scientists elucidate the role of Wnt pathway activation in mediating resistance to androgen receptor signaling inhibition and identify a robust molecular signature for predicting treatment outcomes. 💊 go.nature.com/3OFOUTe

New in @CR_AACR! 🙌 A team of scientists from the @GarvanInstitute analyzed cancerous and adjacent-benign cores from patients with hormone therapy–naïve localized #prostate cancer using scRNA-seq. 💡 bit.ly/4mQPUkh