Konstantopoulos Lab

Proud of our brilliant PhD student @nath_sanjiban2 for receiving the @HopkinsEngineer Teaching Assistant Excellence Award. Sanjiban served as TA for the graduate-level Transport Phenomena course. He is an excellent teacher and amazing researcher. Stay tuned for what’s next!

4/4 Proud of Dr. @alice_amitrano for her work on how mechanochemical cues control cell behavior. Alice has first-author papers in Science Advances, Cell Reports, and COCB, with another in review, plus work in journals such as Nano Letters, and NatMaterials. Exciting work ahead!

3/4 Proud of Dr. @YQinling for her work on the function of membrane transporters in cell migration. Qinling, our cell biology expert, has first-author papers in Science Advances and Cell Reports, and work in journals such as NatComm and PNAS. Looking forward to her future success

1/4 Excited to share that 3 of my doctoral students have successfully defended their theses! Congratulations to @Anindya_SenJHU, @YQinling and @alice_amitrano on this major milestone. They are outstanding researchers and people. Looking forward to seeing all they accomplish next.

Huge congratulations to our brilliant PhD student @BhawanaAg12 for winning the WSE @HopkinsEngineer Excellence in Research Trainee Award and being selected as 1 of only 7 presenters (out of 186 abstracts) at the @JohnsHopkins DOM/WSE Research Retreat. Incredible achievement! 🔬👏

💡Chronic adaptation to acidosis is not universal and relies on the cancer cell ability to restrain reactive oxygen species via fatty acid oxidation.

💡Hypoxia restores motility under acidosis by upregulating NHE1/ILK signaling and glycolytic metabolism.

Pleased to share our work on how hypoxia restores acidosis-induced inhibition of cancer cell dissemination- now out in Cell Reports! Led by Se Jong Lee, @alice_amitrano , @YQinling & @debanikch. Many thanks to our lab members and our collaborators! cell.com/cell-reports/f…

The Konstantopoulos Lab is heading to #AIChE2025 in Boston to share our latest discoveries in cell mechanobiology and microenvironmental cues. Stay tuned for exciting talks! #AIChEAnnual🧪

@KKLabJHU dinner at #BMES2025 : great science, even better company 🍽️✨🔬

🎉 Excited to share that the Konstantopoulos Lab will be presenting our latest work at #BMES2025! Come check out our talks, spanning mechanobiology, cancer invasion, and bioengineering innovation. 🧠🔬 See details below 👇

#Preprint alert! Check out @ConfinementLab’s new research on the role of #mechanical #memory in potentiating confined migration: biorxiv.org/content/10.110…

Pleased to share our latest collaborative work with the @DevreotesLab in @PNASNews. Using optogenetics, we show that both insufficient and excessive Ras activity impair cell motility, underscoring the need for optimal Ras signaling and cortical tension. doi.org/10.1073/pnas.2…

🎉After years in the making… our work, @KKLabJHU @AveryTTran, Dr Wisniewski & Dr Kalab, is out in Nature Materials! Anillin & Ect2, best known for their roles in cell division, are repurposed by cancer cells to drive confined migration and extravasation. nature.com/articles/s4156…

1. Many thanks to all of @KKLabJHU lab members and our amazing collaborators Drs. Kalab, Stoletov, Lewis, Friedl, Gu, @GerechtLab, Martin and Wu. This wouldn’t have been possible without you!

In sum, cytoplasmic Anillin and Ect2 enhance RhoA/myosin II-dependent contractility and bleb-based confined cell migration.

Thrilled that our newest work led by @AveryTTran, Dr. Wisniewski, and @mistrigr is out today in @NatureMaterials! We show how the cytokinesis proteins Anillin and Ect2 drive RhoA/ROCK/myosin-mediated invasion in confining spaces in vitro and in vivo. doi.org/10.1038/s41563….