Kamil Nosol

lResearchers from @lab_locher and their coauthors show how hepatitis drug bulevirtide interacts with the receptor for HBV/HDV cell entry. #ntcp #hbv #bulevirtide #slctransporters #membranetransporters nature.com/articles/s4146…

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP | Nat Commun doi.org/10.1038/s41467…

We have exciting news on NTCP! In our very recent study - now out in @NatureComms - we found out how NTCP interacts with the antiviral drug bulevirtide. Congratulations to @Hongtao_Liu2019 and the rest of the team #SLC #CryoEM Find out more here: rdcu.be/dBT8p

Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP biorxiv.org/cgi/content/sh… #bioRxiv

We are excited to share our latest publication on the human liver drug importers OATP1B1 and OATP1B3 in functionally distinct states, now available in @NatureComms Read more about the novel bicarbonate binding site here: nature.com/articles/s4146… #SLCtransporters #cryoEM

ABCG2 meets nanobodies! Check out our new publication on ABCG2 inhibition: sciencedirect.com/science/articl… #ABCtransporters #ABCG2 #nanobodies #cryoEM

New Year, new lab picture!😀

I was dismayed (to say the least) to find @DeepMind AlphaFold predictions come up when I searched for a PDB file at @buildmodels. AF is a useful tool and its great that @uniprot hosts calculated AF predictions, but I see no reason for them to also be hosted by @buildmodels.

new release6 7ZYI: Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody "Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver." Locher lab. Cell. Res.

Check out our new @biorxivpreprint with @mikhailshapiro on the structure of bacterial gas vesicles: doi.org/10.1101/2022.0… Congrats to @przemyslawdutka and all authors!

We are proud to present our newest paper on the structure and mechanism of the human bile salt transporter NTCP. A fantastic team effort! nature.com/articles/s4142… Congratulations #TeamNTCP

WaaL highlights by first author @Khuram_U_Ashraf!

This has been a great week, in a wonderful place, with fantastic people. Thank you @accardilab for organising this. I hope to see you all again soon! @GordonConf #LigandRecognitionAndMolecularGating

Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations pubs.acs.org/doi/10.1021/ac…

We're looking for a post-doc! If you're interested in membrane protein biochemistry & structural biology, see: bit.ly/3E1TzUk #ManciaLab @ColumbiaPS #cryoEM - Please RT!

Congratulations to @KNosol who successfully defended his PhD thesis. You did a fantastic job, Kamil! #ABCTransporters

We are happy to share our latest article, now available online @PNASNews. Check out our #cryoEM structures of the #membranetransporter ABCB4 and more on how the transporter translocates phosphatidylcholine here: pnas.org/content/118/33… Congrats to @KNosol and all the authors!

Structural basis of drug recognition by the multidrug transporter ABCG2 biorxiv.org/cgi/content/sh…

Check out our new @biorxivpreprint with @mikhailshapiro group on using EM to measure gas vesicles: doi.org/10.1101/2021.0…

@spant_18 @tcbguiuc @emadtaj @BeckmanInst pnas.org/content/117/42…

Our new pre-print where we propose a novel inhibitory mechanism for tariquidar, and for related 3rd-gen Pgp inhibitors, where lipids are seen to enhance the inhibitory role in the catalytic cycle of membrane transporters. biorxiv.org/content/10.110… @tcbguiuc @emadtaj @BeckmanInst