The Karlseder Lab

We are excited that our study on telomere sequencing in collaboration with @nanopore is published nature.com/articles/s4146… We developed Telo-seq, a method to determine the length and composition of entire human telomeres in bulk, chromosome arm and in some cases allelic resolution

Introducing Telo-seq: a new tool from @SalkInstitute and Oxford @Nanopore that will revolutionize the study of aging and cancer. Scientists can now measure and sequence telomeres on individual chromosomes with unprecedented resolution. #SalkHealthyAging salk.edu/news-release/u…

Please also check out complementary work on telomere sequencing from the Artandi lab (@SCIDirector) published in the same issue @NatureComms nature.com/articles/s4146…. Congrats to Santiago (@santiagokique) and all collaborators!

We applied Telo-seq to resolve telomere dynamics during cellular aging and reprogramming as well as differences in TERT- and ALT-positive cancer cells. Congrats to the entire team and big thanks to all our collaborators! @NatureComms

We are excited that our study on telomere sequencing in collaboration with @nanopore is published nature.com/articles/s4146… We developed Telo-seq, a method to determine the length and composition of entire human telomeres in bulk, chromosome arm and in some cases allelic resolution

In parallel to us, the Artandi lab has also established telomere long-read sequencing. Check out their preprint:

Learn how @KarlsederLab & team used nanopore technology to investigate telomere shortening during cellular aging. Check out how they also studied how alternative lengthening of telomeres and telomerase impact iPSCs and cancer cells. Read more: bit.ly/46AgRPb

Don't miss out on this event!

In collaboration with @nanopore we developed a method to sequence entire human telomeres and determine bulk and chromosome arm-specific telomere length.

Our preprint “High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer” is now on bioRxiv. biorxiv.org/content/10.110…

Our latest review 'Telomeres as hotspots for innate immunity and inflammation' is now live @repair_dna! Here, we describe how dysfunctional telomeres activate innate immune pathways and fuel inflammaging. Check it out @Sprzetocka @KarlsederLab doi.org/10.1016/j.dnar…

This is a fantastic chance for anyone interested in the interplay between mitochondria and innate immune responses!

Our lab website is now live! Explore opportunities and learn about our research on telomere-mitochondria-innate immunity crosstalk at nassourlab.com

Postdoc positions are available in our group at the University of Colorado @cuanschutz to study the crosstalk between telomeres and mitochondria in innate immunity. See details below, and feel free to DM or email me for further info!

Some tumors repair their DNA via microhomology-mediated end joining (MMEJ), rather than with homologous recombination (HR). Scientists find that MMEJ relies on the APE2 nuclease, revealing a chink in the armor of HR-deficient cancers. @ArnoultLab ow.ly/jv8y50NHfLT

Great job to the Arnoult lab for their recent publication in Molecular Cell! Their study highlights the critical role that APE2 nuclease plays in Pol Theta-mediated MMEJ. Congratulations!🥳

Excited to share this spotlight on @MolecularCell with @LiuhYow, highlighting a telomere-dependent tumor suppressive mechanism via mitochondria that acts during replicative crisis from @NassourJoe @KarlsederLab authors.elsevier.com/c/1gtA73vVUPNx…

JOB OPPORTUNITY! 🧠🔬🧪 9 labs at Salk have joined forces to understand how aging contributes to Alzheimer’s + other age-associated conditions. The team is seeking talented postdoctoral fellows who can work across disciplines. Please RT and share! recruiting2.ultipro.com/SAL1013SIBS/Jo…

Our results also indicate that TZAP binding to telomeres induces telomere dysfunction and ALT-like activity, leading to the generation of t-circles and c-circles through a BTR-dependent process. Congrats to Sara (@Sara_Priego_89), Javier, and the entire team!

We found that efficient TZAP recruitment to telomeres occurs when telomeric chromatin is open due to the loss of ATRX/DAXX, independently of H3.3 deposition.

Our latest study, in collaboration with @ErosLazzerini, sheds light on the molecular mechanisms of the pathway triggered by the telomeric-associated zinc-finger protein (TZAP) in human cancer cells. cell.com/iscience/fullt…