Steven Artandi, MD, PhD

Ronald Castellino, pioneer in oncologic radiology, dies at 88. Castellino founded the first #RadiationOncology division at Stanford , led the diagnostic radiology department, and made important contributions to research in imaging the lymphatic system.brnw.ch/21x2JP5

SCI member Beth Beadle & others report that in p16+ #OropharyngealCancer, quality of life outcomes at 6 months were similar for accelerated radiation with cisplatin or cetuximab, with persistent issues in dry mouth, sticky saliva, and senses. brnw.ch/21x2JOy

SCI member Chris Garcia & others use catch-bond engineering to enhance weak TCRs, boosting TCR potency against prostate cancer antigens while maintaining specificity. This strategy could overcome immune tolerance and improve TCR-based #CancerImmunotherapy. brnw.ch/21x2D6I

SCI member Nathanael Gray & others report that TRAP-1, a mutant-specific small molecule, activates p53Y220C via a ternary complex, restoring tumor suppressor function and inducing senescence and apoptosis in cancer cells. brnw.ch/21x2B1m #DrugDiscovery

SCI member Lei Qi & others show that engineered trogocytosis enables programmable #MacromoleculeDelivery, allowing tunable, cell-specific transfer of therapeutic proteins and genome-editing tools across diverse cell types. brnw.ch/21x2wNv #ProteinDelivery

A multidisciplinary expert thoracic panel, including SCI members Joel Neal and Joseph Shrager, released 19 consensus recommendations on managing locally advanced #LungCancer, covering resectability, neoadjuvant, and adjuvant therapies. brnw.ch/21x2sDC

SCI Esther John & others found that adding polygenic risk scores (PRS) to mammographic density (MD) didn’t improve contralateral #BreastCancer (CBC) risk prediction. MD remains the main predictor for CBC risk. brnw.ch/21x2obk

SCI member @AaronNewmanLab & others report a machine-learning framework identifying nine #SpatialTME ecotypes in the TumorMicroenvironment, linked to immunotherapy response and detectable in plasma cfDNA. brnw.ch/21x2iAF

SCI member Marvin Langston & others found that renal cell carcinoma incidence >, particularly among Hispanic, Black, and low-nSES groups. While overall mortality <, these groups faced > death rates, highlighting #RCC health equity concerns. brnw.ch/21x2frh

A @STS_CTsurgery panel, including SCI member Joe Shrager, developed 19 consensus recommendations on managing locally advanced #NSCLC, focusing on resectability, the role of neoadjuvant & adjuvant therapies, & multidisciplinary treatment approaches. brnw.ch/21x2bhI

SCI member @SurbhiSidanaMD & others found that high #BCMA expression at baseline predicts better outcomes with BCMA CAR-T therapy in #MultipleMyeloma. However, BCMA expression often decreases at relapse, which may impact future treatment strategies. brnw.ch/21x272Z

SCI member @l_schapira & others found that in young female cancer survivors, fear of cancer recurrence (FCR) predicts future chronic pain, but pain does not predict FCR. brnw.ch/21x22Yt

SCI member @sumitshahMD & others studied virtual cancer second opinions, finding over half of patients received new treatment recommendations, showing online expert review can improve care access and guide better treatment decisions. brnw.ch/21x1YHQ

SCI member Ami Bhatt & others uncover a recent expansion of mobile DNA (ISL3) driving rapid genome changes in E. faecium, even within patients. In cancer transplant patients, this may help fuel adaptable, hard-to-treat infections. #MicrobialEvolution brnw.ch/21x1Ufi

SCI member Xuejun Gu & others developed TLC-nnUNet, improving #BrainMetastasis detection by focusing on small lesions and reducing false positives. Shows better accuracy across lesion sizes & holds promise for clinical use in stereotactic radiosurgery. brnw.ch/21x1PSu

SCI member @liaojoe1 & others report that a 3 gene urine RNA test can accurately detect and monitor #BladderCancer, offering a noninvasive tool that may help reduce or better time cystoscopies in clinical care. brnw.ch/21x1LnW

SCI member @LivnatJerby & others show #CRISPR activation screens uncover RNA-based mechanisms that sensitize cancer cells to T cell killing and reveal gene interactions like Wnt that can restore targeted immune elimination. brnw.ch/21x1H0i

SCI member @RaviMajetiMD & others show DNMT3A R882 mutations drive #AML initiation but are dispensable for maintenance, as CRISPR correction didn’t affect engraftment—highlighting distinct roles in initiation vs persistence. brnw.ch/21x1yEJ

SCI member Ami Bhatt& others report that post-transplant cyclophosphamide disrupts the gut microbiome more than standard GVHD prevention—yet improves outcomes, challenging the link between diversity and success. brnw.ch/21x1ujV

SCI member @MullallyLab & others created a model to predict survival in patients with #TP53 mutations in myeloproliferative neoplasms. Key factors like bone marrow scarring, multiple TP53 mutations, and a higher risk score linked to shorter survival. brnw.ch/21x1q72