Klipp-Linding Laboratory

For the first time, researchers have simulated nearly every chemical reaction in a living bacterial cell go.nature.com/46UnkYp

Biomacromolecules are delivered across the blood–brain barrier when administered systemically go.nature.com/412exBi rdcu.be/eRyTm

Universal differential equations for systems biology: Current state and open problems biorxiv.org/content/10.110…

🔍 How can #bioinformatics enhance #AI in #lifesciences? Prof. Peer Bork, Director of @EMBLHeidelberg, shares his insights, and discusses the need for data infrastructure collaboration to drive innovation. 🎥 Watch the video, recorded at #ECCB2024 👇 @BorkLab

🎉Exciting news! The @Icy_BioImaging team, along with @deepImageJ, is thrilled to announce the release of the 𝗝𝗮𝘃𝗮 𝗗𝗲𝗲𝗽 𝗟𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗟𝗶𝗯𝗿𝗮𝗿𝘆 (𝗝𝗗𝗟𝗟), the new open source core library for #DeepLearning model inference in imaging! 🤖

Early registration deadline is Wednesday! Please join us for this exciting conference! asbmb.org/meetings-event…

Truly excited that our collaboration with @CantleyLab and @LabYaffe, led by the mighty Jared Johnson and the unstoppable @Tomer_M_Yaron, to map substrate motifs for the Ser/Thr kinome is now out! Literally a project that spanned decades. nature.com/articles/s4158…

Nature research paper: An atlas of substrate specificities for the human serine/threonine kinome go.nature.com/3GC1734

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Conference Website icsb2022.berlin Abstract Submission Now Open - easychair.org/conferences/?c…

Join us October 6-8, 2022 for #COMBINE2022! Co-located with #ICSB2022. In Berlin (Germany). COMBINE Community meet-up Oct 6-7, 9a.m.-6p.m ** COMBINE Forum Oct 8, 8a.m.-1:30p.m. Details and Call for papers to come. Be on the look out!

A global atlas of substrate specificities for the human serine/threonine kinome biorxiv.org/content/10.110…

Deep Hidden Physics Modeling of Cell Signaling Networks - Rune Linding youtu.be/DxYfnHbtr9s

Shapes of Cell Signaling sciencedirect.com/science/articl…

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells | Disease Models & Mechanisms | The Company of Biologists journals.biologists.com/dmm/article/14…

Deep Hidden Physics Modeling of Cell Signaling Networks eurekaselect.com/194063/article

Simone performed as series of independent simulations from different parts of the landscape to characterise the binding mechanism and minima. We isolate a transition state btw intermediate and bound state, but suggest that binding overall is limited by an entropic barrier. 3/4

Happy to share a new preprint by @simo_bolognini on the transient exposure of a buried phosphorylation site in an autoinhibited protein. He used metadynamics and unbiased MD to examine how the inhibitory module folds upon binding to the Vav1 DH domain. 1/4 biorxiv.org/content/10.110…

Open schools! Given current vaccination strategies (yellow) and low vacc levels, closed schools (gray) cause no significant drop of infections, no reduction in deaths or ICU demand, no prevention of next wave, our model shows. Focus on masks/distancing and fast broad vaccination!

@CellReports twitter.com/lindinglab/sta…

Deep neural networks identify signaling mechanisms of ErbB-family drug resistance from a continuous cell morphology space bit.ly/3c3lQiL