KOL Pulse AI

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KOL Pulse AI

KOL Pulse AI

@KolPulseAI

Instant insights from oncology’s top voices. Download the free Chrome Extension that tracks trials, sentiment & influence on X.

Savannah, GA Katılım Ağustos 2023
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KOL Pulse AI
KOL Pulse AI@KolPulseAI·
Quick takes on the Social Signals from #ASCO26. 🧬 RASolute-302: @marklewismd 's tweet regarding the standing ovation for RASolute-302 really made that trial stand out. The momentum here was massive, fueled by high expectations from the @RevMedicines PR, #AACR26 presentations,and the high-profile Ben Sasse interviews. ⚔️ PROTEUS: One of the more interesting trials from a social media perspective, as the radiation oncology community on X was highly critical of the trial's surgical paradigm. 🔄 CROWN: Felt a bit like an incredible replay of the Plenary from years ago—steady, practice-confirming data. 🎬 HARMONi-6: Perhaps the most compelling narrative twist. The discussant, Dr. Julie Brahmer, masterfully set up the Plenary audience using The Devil Wears Prada as a research metaphor. It begs the question: Is VEGF back? 🚀 LIBRETTO-432: A massive surprise for many attendees. Lung cancer specialists were thrilled about @LillyOncMed selpercatinib in the adjuvant setting for RET-positive NSCLC. The core takeaway from @christine_lovly presentation was loud and clear: "This is why we test." 🔬 OPTIMA: Really got the breast cancer community excited about using @Veracyte 's test to safely reduce the chemotherapy burden for many of their patients. 📦 WU-KONG28: Had such an interesting vibe. Great data from @Dizal_Global , but it leaves the KOLs asking the same commercial question: Why isn't this readily available to patients in the US yet? Follow the #ASCO26 Pre and Post highlights here: kolpulse.com/kol-pulse-asco…
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KOL Pulse AI
KOL Pulse AI@KolPulseAI·
Featuring 👉 @sbkim712 : "Our OPTIMAL trial is now in print in the July 2026 @Annals_Oncology oral paclitaxel (DHP107) is non-inferior to weekly IV paclitaxel in HER2− metastatic breast cancer — same efficacy, less neuropathy, no infusion. Now MFDS-approved in Korea (weekly). #BCSM" — @sbkim712 🔬 What's Hot in Hematology/Oncology — KOL Pulse Daily Digest (Jul 13) 🫁 Lung: Community discusses TREASURE trial details and lifestyle medicine. 🎗️ Breast: Phase III OPTIMAL puts oral paclitaxel on the map in HER2- metastatic breast cancer; new real-world HR+/HER2- recurrence data 🔵 GI: Long-term TOPAZ-1 data and PERISCOPE II results shared 🔷 GU: FDA expands EV+pembro in MIBC; new RCC, mHSPC data 🟣 Myeloma: Isatuximab OBI approved; new trial for myeloma kidney disease 🩸 Heme: CD22 CAR-T shows responses in post-CD19 CAR-T DLBCL More from: @Eddie_Cliff (CD22 CAR-T in post-CD19 DLBCL), @ArndtVogel (TOPAZ-1 in Biliary Tract Cancer), @DrChoueiri (OMNIVORE study in RCC) Full story, verbatim KOL quotes + sources 👉 hubs.ly/Q04pwrsw0
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KOL Pulse AI
KOL Pulse AI@KolPulseAI·
SERENA-6 (camizestrant — ctDNA-guided early switch in ESR1m HR+/HER2- breast cancer): extended analysis now published in @TheLancet The KOL debate continues. Strong PFS + ctDNA clearance signal — but @dr_yakupergun flags that OS remains immature: "the current curves do not show a clear separation." US FDA decision still pending after the 6-3 ODAC vote. Follow what oncologists are actually saying 👇 hubs.ly/Q04pvTCM0
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Mark Faber
Mark Faber@MarkFaberDO·
@allisonoconn Bad news: it can cause severe anemia and thrombocytopenia during the first 2 months, and the response rate is far under 50%…
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KOL Pulse AI
KOL Pulse AI@KolPulseAI·
AstraZeneca is acquiring global rights to Zegfrovy (sunvozertinib) from Dizal — $600M upfront + up to $900M in milestones. Zegrovy is FDA-approved 2L+ EGFR exon20ins NSCLC (WU-KONG1B) and just beat chemo first-line in Phase 3 WU-KONG28: PFS 10.3 vs 7.5 mo (HR 0.65), ORR 58.9% vs 31.1% (#ASCO26 / NEJM). See what thoracic oncologists — @lungoncdoc , @LeXiuning , @StephenVLiu , @tnewsomdavis — have been saying 👇 👉WU-KONG1B(FDA Approved): hubs.ly/Q04ptSyK0 👉WU-KONG28(#ASCO26): hubs.ly/Q04pvfxM0 @AstraZeneca
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Stephen V Liu, MD
Stephen V Liu, MD@StephenVLiu·
FINALLY! AstraZeneca reaches deal with Dizal to bring sunvozertinib to the US! Approved for EGFR exon 20 NSCLC over a year ago but only available in China (and at a different dose). This deal comes off phase 3 WU-KONG28 showing superiority over 1L chemo. astrazeneca.com/media-centre/p…
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James Zou
James Zou@james_y_zou·
Bio databases/APIs weren't designed for AI agents🧬 So we expanded #Paperclip to transform common molecular databases—UniProt, PDB, ChEMBL—into a unified agent-native virtual filesystem. Now you can do deep research across 10^6 molecules much more accurately and 10x faster! All integrated with millions of full-text papers also indexed in Paperclip. Free to use gxl.ai/blog/adding-bi…
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Nurullah İlhan,MD
Nurullah İlhan,MD@drnurullahilhan·
SERENA-6 Phase 3: Switching to camizestrant upon ctDNA-detected ESR1 mutation BEFORE progression (1L HR+/HER2- advanced BC) → Median PFS: 16.8 vs 9.2 months (HR 0.45) → Also significant PFS2 benefit ctDNA-guided early switch is here. Biomarker-driven treatment is becoming reality. @OncoAlert @matteolambe @elmayermd @mcristofanill @KalinskyKevin @ErikaHamilton9 @stolaney1 @DrSGraff @hoperugo #SERENA6 #ctDNA #BreastCancer #Oncology
OncoAlert@OncoAlert

Switching to camizestrant at ESR1 🧬 mutation emergence before disease progression during first-line treatment of hormone receptor-positive advanced breast cancer (SERENA-6) buff.ly/JWpPzFF The phase 3 SERENA-6 trial demonstrated that prospective ctDNA monitoring for emerging ESR1 mutations can guide early therapeutic intervention in hormone receptor-positive, HER2-negative advanced #BreastCancer . Patients who switched from an aromatase inhibitor 💊 to camizestrant while continuing CDK4/6 inhibition at ESR1 mutation detection achieved significantly longer progression-free survival (16.8 vs 9.2 months; HR 0.45) and improved second progression-free survival, supporting biomarker-driven treatment adaptation before clinical progression. @elmayermd @mcristofanill @BianchiniGP @KalinskyKevin @MOliveira_MD @matteolambe @aftimosp @E_de_Azambuja @DrSGraff @ErikaHamilton9 @double_whammied @maryam_lustberg @raalbany @hoperugo @stolaney1 @LoiSher @SirohiBhawna @jamecancerdoc @JavierCortesMD @JaniceTNBCmets @Prof_Nadia_H @nataliagandur @FernandoOnco @ElisaAgostinett @to_be_elizabeth @realbowtiedoc @Lucarecco @GaiaGriguolo @amandaNizamMD @DrVilmaPBarcia @DaisukeKotani @DraMartinezLago @DraMartinezLago @UOzkerim @mariobalsamd

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FiercePharma
FiercePharma@FiercePharma·
Nearly a decade after spinning out its Chinese research hub to form Dizal Pharmaceutical, AstraZeneca is paying up to $1.5 billion to buy a piece of the pipeline, securing exclusive global rights for the biotech’s oral EGFR lung cancer drug Zegfrovy. fiercepharma.com/pharma/astraze…
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KOL Pulse AI retweetledi
The ASCO Post
The ASCO Post@ASCOPost·
🖥️ #ASCOAI: Responsible #AI starts with responsible governance @TJCommission has launched the Responsible Use of AI in Healthcare certification, recognizing health systems with robust AI oversight, monitoring, transparency, and patient safety practices. 🔗 ascoai.org/articles/2026/…
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Stephen V Liu, MD
Stephen V Liu, MD@StephenVLiu·
Secondary analysis of phase 3 LIBRETTO-431 @JTOonline. In RET+ NSCLC, selpercatinib superior to chemo +/- IO. This analysis compared chemo alone vs chemo-IO in control arm: found no difference in PFS or OS between two groups. jto.org/article/S1556-…
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Yakup Ergün
Yakup Ergün@dr_yakupergun·
The SERENA-6 PFS2 results were presented at #ASCO26 . The full-text is now published, but the OS data remain immature. The current curves do not show a clear separation. Whether an OS benefit will emerge with longer F/U remains an open question. thelancet.com/journals/lanon…
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KOL Pulse AI
KOL Pulse AI@KolPulseAI·
🚨 FDA APPROVAL, March 5, 2026 — Tec-Dara (teclistamab + SC daratumumab; Tecvayli + Darzalex Faspro, @JNJ) for R/R myeloma, ≥1 prior line. MajesTEC-3: PFS not reached vs 18.1 mo (HR 0.17); 36-mo OS 83% vs 65%. KOLs react 👇 hubs.ly/Q04pmvF60 @mvmateos @VincentRK
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