
KOL Pulse AI
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KOL Pulse AI
@KolPulseAI
Instant insights from oncology’s top voices. Download the free Chrome Extension that tracks trials, sentiment & influence on X.












Switching to camizestrant at ESR1 🧬 mutation emergence before disease progression during first-line treatment of hormone receptor-positive advanced breast cancer (SERENA-6) buff.ly/JWpPzFF The phase 3 SERENA-6 trial demonstrated that prospective ctDNA monitoring for emerging ESR1 mutations can guide early therapeutic intervention in hormone receptor-positive, HER2-negative advanced #BreastCancer . Patients who switched from an aromatase inhibitor 💊 to camizestrant while continuing CDK4/6 inhibition at ESR1 mutation detection achieved significantly longer progression-free survival (16.8 vs 9.2 months; HR 0.45) and improved second progression-free survival, supporting biomarker-driven treatment adaptation before clinical progression. @elmayermd @mcristofanill @BianchiniGP @KalinskyKevin @MOliveira_MD @matteolambe @aftimosp @E_de_Azambuja @DrSGraff @ErikaHamilton9 @double_whammied @maryam_lustberg @raalbany @hoperugo @stolaney1 @LoiSher @SirohiBhawna @jamecancerdoc @JavierCortesMD @JaniceTNBCmets @Prof_Nadia_H @nataliagandur @FernandoOnco @ElisaAgostinett @to_be_elizabeth @realbowtiedoc @Lucarecco @GaiaGriguolo @amandaNizamMD @DrVilmaPBarcia @DaisukeKotani @DraMartinezLago @DraMartinezLago @UOzkerim @mariobalsamd





In an analysis of a multi-center trial involving 628 patients with high-risk melanoma receiving adjuvant pembrolizumab, Othus et al. identified optimal time cut-points for the first infusion of 1:18 pm for recurrence-free survival and 3:48 pm for overall survival (OS). These findings, however, did not reach statistical significance regarding patient outcomes. Furthermore, the lack of threshold robustness was demonstrated when shifting the OS cut-point 30 minutes earlier, which yielded a hazard ratio of 0.98. Average infusion times trended earlier over the year, while appointments were on average later for patients living further from the treatment center. bit.ly/4vujte8 @fredhutch





The SERENA-6 PFS2 results were presented at #ASCO26 . The full-text is now published, but the OS data remain immature. The current curves do not show a clear separation. Whether an OS benefit will emerge with longer F/U remains an open question. thelancet.com/journals/lanon…







