Kunal

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

my biggest health life hack is always having something to look forward to that you’re excited about and training for a race, marathon, event a few months away our brains are wired for pursuit of a goal, you just have to engineer that goal

People get high on abstraction too early. They want the system before they’ve earned the insight. But the good abstractions are never designed. They’re discovered. You do the stupid manual thing enough times and the real bottleneck just emerges. Your initial agency might be driven by a hunch you had in the shower, but that moment won’t get you all the way to making something people want. The right way to make anything is forced on you by reality: what are the real jobs to be done? And what sequence? This is why “do things that don’t scale” still hits, especially now when AI makes it trivially easy to scale things that probably shouldn’t be scaled yet. PG’s point was never about suffering. It was about contact. When you’re the one manually doing the loop, you see the edge cases. The weird user behavior. The failure modes nobody designed for. The hidden dependencies that only show up at 2am when some flow or intermediate step breaks in a way you didn’t anticipate. If you automate before you have that contact, you just scale your misunderstanding faster. When the machines can help you vibe code perfection it gives you a false sense of power. I love that feeling as much as you do. But fuck perfection. Do it live. Be the loop. Feel every friction point. Notice what’s actually true every single time versus what just looked true because you hadn’t seen enough cases yet. Formalize that. Build the recursive version. Then keep checking that your abstraction is still attached to real humans and their needs. Because reality drifts. Your users drift. The ground truth changes under you. You may think you understand but no plan survives contact with the real users and what they want. You find those body blows in analytics and user feedback and we call them the roadmap. Humans left with not enough data hallucinate too. But just like the LLMs with enough data you unlock real transcendence. Real utility. Prosperity for humans in real life. The abstraction is a tool, not a destination. The moment you forget that, you’re cooked.