Lara Pferdehirt

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Lara Pferdehirt@LPferdehirt·2 Eki

Thrilled to have met the new @RiceUniversity President @RDesRoches at the #NAE meeting this year! Congratulations on your induction to the class of 2020! @theNAEng

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The Upper Hand Podcast@HandPodcast

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The Guilak Lab@Guilak_Lab·2 Ağu

You're going to have to tune into @handpodcast if you want to learn @Farsh_G's answer to this pressing question in this sneak peak!

Sneak peak of a new episode dropping tomorrow! Learn from @Farsh_G - one of the GOAT's of orthopedic research - about mentoring and navigating career pivots. Can't miss this one! @Congenitalhand @ChrisDyMD @Guilak_Lab @WUSTLortho #handsurgery #orthotwitter

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@ChappellLab @NAR_Open @andrea_faint @MaClaVK @WelchFoundation @MaybeItsBob

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Lara Pferdehirt@LPferdehirt·29 Tem

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Chappell Lab@ChappellLab·9 Tem

Check out our latest paper in @NAR_Open - a fantastic effort by @andrea_faint, @MaClaVK and Katherine! We applied synbio tools to activate normally silent natural products in Streptomyces! Thanks to @WelchFoundation for supporting the work. academic.oup.com/nar/advance-ar…

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Farshid Guilak@Farsh_G·3 Haz

Please join me June 13, 12pm CT for a webinar on my favorite topic: “I was trained how to do everything but run a lab!” The lecture is free on the AOCConnect platform. Just register (no cost) as a researcher: aoc-ortho.com & the info will be sent from there. (1/3)

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Society for Research on Biological Rhythms@SRBR_Outreach·31 May

Synthetic gene circuits to support daily #rhythms in cartilage -- a strategy for creating cell-based therapies to preserve the #circadian #clock in the presence of inflammation. @ScienceAdvances (tinyurl.com/22ppxlg5) @Farsh_G @ErikHerzog @LPferdehirt

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Lara Pferdehirt@LPferdehirt·28 May

@papersofnote Thanks for highlighting!!

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Annika Reads@papersofnote·27 May

Also, more broadly, these finding suggest that therapies that address inflammation mediated disruption of clocks in peripheral tissues may be able to restore critical aspects of tissue function!

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Annika Reads@papersofnote·27 May

Sometimes recapitulating a system in culture teaches you something new! @LPferdehirt and colleagues engineer mouse iPSCs to create chondrocytes that resist inflammation-induced clock disruption and loss of matrix production. doi.org/10.1126/sciadv…

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Extracellular Matrix News@ExtracellMatrix·27 May

Dr. Lara Pferdehirt (@LPferdehirt), @AnnaRDamato, and Dr. Farshid Guilak's group (@Farsh_G) at @WUSTLmed developed genetically engineered #cartilage from #iPSCs capable of preserving the circadian clock 🕐 in the presence of #inflammation. Read more 🔗: bit.ly/39XizT0

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Lara Pferdehirt@LPferdehirt

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Farshid Guilak@Farsh_G·27 May

Another fun result in @LPferdehirt's & @annardamato's study - stem cells (iPSCs) don't have a circadian rhythm, but as they differentiate to chondrocytes, they develop a 24 hr clock, similar to primary chondrocytes (which will continue to cycle for over a week outside the body!)

How do you combine #synbio and #circadianrhythms to protect #cartilage? Check out our work in @ScienceAdvances on clock-preserving circuits that maintain circadian rhythms in the presence of #inflammation - with @annardamato & the Herzog and Meng labs! science.org/doi/10.1126/sc…

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Lara Pferdehirt@LPferdehirt·26 May

@jbrunger @ScienceAdvances @annardamato @Farsh_G @Guilak_Lab @ErikHerzog @MichalDudekPhD @shrinershosp @WUSTLortho @WashUBME @WUSTLBio Thanks Jonathan!!

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Lara Pferdehirt@LPferdehirt·25 May

How do you combine #synbio and #circadianrhythms to protect #cartilage? Check out our work in @ScienceAdvances on clock-preserving circuits that maintain circadian rhythms in the presence of #inflammation - with @annardamato & the Herzog and Meng labs! science.org/doi/10.1126/sc…

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Lara Pferdehirt@LPferdehirt·26 May

@mamareen8 @ScienceAdvances @annardamato @Farsh_G @Guilak_Lab @ErikHerzog @MichalDudekPhD @shrinershosp @WUSTLortho @WashUBME @WUSTLBio Thank you!

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Lara Pferdehirt@LPferdehirt·26 May

@MichalDudekPhD @ScienceAdvances @annardamato @Farsh_G @Guilak_Lab @ErikHerzog @shrinershosp @WUSTLortho @WashUBME @WUSTLBio Thank you and congrats to you too! Fantastic collaboration effort by all

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Michal Dudek@MichalDudekPhD·26 May

@LPferdehirt @ScienceAdvances @annardamato @Farsh_G @Guilak_Lab @ErikHerzog @shrinershosp @WUSTLortho @WashUBME @WUSTLBio Congratulations Lara and Anna! I'm happy I was able to contribute to this work!

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Lara Pferdehirt@LPferdehirt·26 May

@ramos_yfm @ScienceAdvances @annardamato @Farsh_G @Guilak_Lab @ErikHerzog @MichalDudekPhD @shrinershosp @WUSTLortho @WashUBME @WUSTLBio Thank you!!

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YFMRamos@ramos_yfm·25 May

@LPferdehirt @ScienceAdvances @annardamato @Farsh_G @Guilak_Lab @ErikHerzog @MichalDudekPhD @shrinershosp @WUSTLortho @WashUBME @WUSTLBio So cool! Congrats Lara!

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Lara Pferdehirt@LPferdehirt

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Farshid Guilak@Farsh_G·25 May

So excited for first of several studies in our new area of synthetic #chronogenetics! Amazing work by @LPferdehirt & @annardamato in collaboration with @ErikHerzog & the Meng lab to show that we can use #synbio to prevent loss of circadian rhythms! @ShrinersStLouis @wustlcrm

How do you combine #synbio and #circadianrhythms to protect #cartilage? Check out our work in @ScienceAdvances on clock-preserving circuits that maintain circadian rhythms in the presence of #inflammation - with @annardamato & the Herzog and Meng labs! science.org/doi/10.1126/sc…

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Lara Pferdehirt@LPferdehirt·25 May

@DJSchwartzLab Thank you!!

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Lara Pferdehirt@LPferdehirt

Lara Pferdehirt retweetledi

Erik Herzog@ErikHerzog·25 May

Are you ready to learn about chronogenetics? Read about this cool collaboration with @Farsh_G, @annardamato, @LPferdehirt et al. engineering cells to protect against #osteoarthritis.

How do you combine #synbio and #circadianrhythms to protect #cartilage? Check out our work in @ScienceAdvances on clock-preserving circuits that maintain circadian rhythms in the presence of #inflammation - with @annardamato & the Herzog and Meng labs! science.org/doi/10.1126/sc…

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