Extracellular Matrix News

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Scientists out of @uamshealth alongside Dr. Rushita Bagchi (@rush6782) and Somaya Ibrahim synthesize current insights into the molecular and cellular mechanisms by which resident naïve redefine resident cardiac fibroblasts as the dominant drivers of #ECM remodeling and #fibrosis. Read more here: bit.ly/3Tw9iID

Researchers developed an ECM–inspired dielectric film that enhances energy storage by improving molecular polarization, suppressing charge leakage, and increasing electrical breakdown strength. bit.ly/4fDsn2Q

Scientists report a bioorthogonally reinforced #ECM-mimetic granular hydrogel platform assembled from complementary gelatin and hyaluronic acid–derived microparticles that anneal through dynamic hydrazone coupling. Learn more here: rsc.li/3TsfoK3

Researchers at @OfficialUoM investigated the association between cellular niches and their surrounding matrix environment during allergic airway inflammation in two commonly used in-bred mouse strains. @MolSystBiol | bit.ly/4pApUux

Dr. Isable Goncalves and team at @lunduniversity provided the first comprehensive spatial transcriptomics map of cell communication in human plaque microenvironments. 🗺️ A pivotal role of a fibroblast-like VSMC, orchestrating intraplaque cell signaling and contributing to plaque stability, was identified. 👉 bit.ly/4wfXDw5

In this study, the functional role of SIRT5 in cardiac fibrosis was evaluated through CFB-specific knockout and overexpression of Sirt5 in mice. 🐁 @CircAHA | bit.ly/4fug6O4

Dr. Long Shao and scientists at @UTHealthHouston identified myeloid #MatrixMetalloproteinase-14 as a key driver of #obesity-associated inflammation and metabolic dysfunction, linking ECM remodeling to insulin resistance and fatty liver disease. 🥼 @CellReports | bit.ly/4w906rW

The authors dissect the design principles for #hydrogels to mimic key #ECM features, including biochemical composition, spatiotemporal microenvironment, and tunable mechanical properties. bit.ly/458OPvN

Researchers identify dermal papillary #fibroblasts as drivers of persistent granulation tissue formation in junctional #epidermolysis bullosa, revealing TGFβ signaling as a promising therapeutic target. ▶️ bit.ly/44mjSnD

The authors highlight how #ECM remodeling and cancer-associated fibroblasts drive tumor progression and fibrosis, revealing new biomarkers and therapeutic targets across cancers. 📖 bit.ly/4vAWNZz

Researchers identify an ATP6AP2–MMP14 signaling axis that drives #osteocyte maturation and cortical bone remodeling, revealing a key mechanism of healthy bone development. 📝 go.nature.com/3T3t2D5

Investigators develop an #ECM-mimetic injectable hydrogel that restores a hypoxic microenvironment, reduces nucleus pulposus cell senescence, and promotes regeneration to slow intervertebral disc degeneration. 🔖 bit.ly/4fyCUgR

The @FDA has granted Orphan Drug Designation to @GRI_BIO's candidate GRI-0621 for the treatment of idiopathic #PulmonaryFibrosis, providing key development and commercial benefits for the progressive lung disease therapy. 💊 Press release: bit.ly/4f7FEjU

New work shows that hyperbaric #OxygenTherapy ameliorates carbon monoxide-induced #CardiacFibrosis by activating the NRF2/ROS pathway and inhibiting the TGF-β1/Smad pathway to stop the transition of cardiac fibroblasts into myofibroblasts. Read the study: bit.ly/4veUsDn

Interested in #HuntingtonsDisease pathology? 🤔 This perspective explores how the brain’s #ExtracellularMatrix may contribute to the spread and toxicity of mutant huntingtin in Huntington’s disease. Learn more: bit.ly/4p3JSgY

Interested in #chitosan-based nanocomposites for targeted colorectal cancer therapy? 🤔 This #review explores how chitosan-based nanocarriers are being developed to improve targeted drug delivery and treatment outcomes for colorectal cancer. 💊 Learn more: bit.ly/4vfvhkg

In this @FASEBorg study, scientists investigated the role and underlying mechanism of circTMEM230 in the degeneration of endplate #chondrocytes. 🔬 Learn more! bit.ly/4eWiVav

Investigators at @tcddublin identified cells contributing to subretinal fibrosis by using Col1a1-YFP reporter mice to noninvasively image #collagen production in real-time in vivo in two disease models, a resolving retinal injury model and a fibrotic model of subretinal disease. 👁️ @PNASNews | bit.ly/4fgABil

Scientists with Dr. Tanya Kalin and Wen Gao at @PhxChildrens identified a unique cluster of #fibrosis-associated pericytes which was not present in normal lungs and exhibited a distinctive transcriptional signature indicating transition of normal pericytes to a fibrotic state. @NatureComms | go.nature.com/4xZbw2L

To determine how vimentin facilitates cell migration through the ECM and around neighboring cells in tissues, researchers at @SyracuseU examined the collective invasion of cell spheroids embedded in #collagen networks. @CommsBio | go.nature.com/4uSJL9u