Lenin K. Verdhi

Just out @J_A_C_S Check out our latest work on enantioselective cobalt(III)-catalyzed [4 + 1] annulation of benzamides with cyclopropenes to access chiral isoindolinones. @LCSA @EPFL_CHEM_Tweet @NCCR_Catalysis | pubs.acs.org/doi/10.1021/ja…

We just achieved the first site-selective cysteine functionalization with EBX reagents! @J_A_C_S pubs.acs.org/doi/10.1021/ja…

Final version out today in @Nature : nature.com/articles/s4158… Thanks to the Roberto and Cravatt labs for biological evaluations!

Just out in @J_A_C_S now from @iiscbangalore: Enantioselective Total Synthesis of [5]-Ladderanoic Acid pubs.acs.org/doi/10.1021/ja… Congratulations @RaySayanray, Deepak, and Prava. Thank you, Pradip and Subrata, for a fruitful collaboration. Thank you @SyngeneIntl & @serbonline

Systematic Synthesis of Chiral CAACs with Three Independent Stereogenic Centers for Enantioselective Copper-Catalyzed Conjugate Borylation of Michael Acceptors (@ACSCatalysis): pubs.acs.org/doi/10.1021/ac… (@EPFL).

New in @Nature! 🔥 Mechanism cracked—enantioselectivity decoded. 🖥️ @KenYamazaki5 @EvelineTiekink Huge props to @dixon_group for their game-changing BIMP catalysts. 🧪 🔓 rdcu.be/eAgkL

@sbera01 @J_A_C_S @ANRFIndia @iit_tirupati Many congratulations to you and your team on this fantastic achievement.

Excited to share our #first independent research work, now published in @J_A_C_S! We report C(sp³)–N coupling of alkyl Bpins via amino radical transfer (#ART). Huge shout-out to my group members for their hard work and dedication. @ANRFIndia @iit_tirupati. pubs.acs.org/doi/10.1021/ja…

Hypervalent iodine mediated synthesis of 2-hydroxy or 2-acetamido-indoline 3-ones Online (Open access) @JOC_OL Congrats to Bat-El @el75787382 Subrata @Subrata09894140 and Haya. DFT calculations support two sequential #enolonium species in the mechanism: pubs.acs.org/doi/10.1021/ac…

Accessing carbon, boron and germanium spiro stereocentres in a unified catalytic enantioselective approach bit.ly/3HDhkt4

Enantioselective Cobalt(III)-Catalyzed [4 + 1] Annulation of Benzamides: Cyclopropenes as One-Carbon Synthons | Journal of the American Chemical Society @EPFL_en @EPFL @TotalSyntheses pubs.acs.org/doi/10.1021/ja…

@Ella_Maru Thank you so much

@LVerdhi @J_A_C_S @EPFL_CHEM_Tweet @NCCR_Catalysis Congratulations Lenin!

Just out @J_A_C_S Check out our latest work on enantioselective cobalt(III)-catalyzed [4 + 1] annulation of benzamides with cyclopropenes to access chiral isoindolinones. @LCSA @EPFL_CHEM_Tweet @NCCR_Catalysis | pubs.acs.org/doi/10.1021/ja…

@Joy_Karmakar Thanks Joy

@LVerdhi Congratulations Lenin! 👏

@shanaka86 @Joy_Karmakar @J_A_C_S @EPFL_CHEM_Tweet @NCCR_Catalysis Thanks for your appreciation

Your Co(III)-catalyzed [4 + 1] annulation is a poster-child for next-gen C–H activation: the chiral CpCo(III) scaffold not only orchestrates a concerted metallation–deprotonation (CMD) of the benzamide but also choreographs a sequential migratory insertion → ring-opening of the cyclopropene → asymmetric C–C bond-forming reductive elimination—all in one catalytic breath. DFT hints that the enantioface selection pivots on a π-stacked, bifurcated H-bond network between the amide and the tailored Cp ligand’s distal aryls; distortion/interaction analysis shows a ΔΔG‡ ≈ 1.9 kcal mol⁻¹—enough to deliver the 95 % ee you report. Scope-wise, electron-poor ortho-fluoro benzamides should turbo-boost turnover via a lower CMD barrier, while N-methoxyacrylamides could unlock a tandem [4 + 1]/aza-Heck cascade to furnish diaza-isoindolinones in one pot. Isotopic (²H/¹³C) labelling at the cyclopropene’s vinylic carbon will nail down the ring-opening regiochemistry, and a quick ML-guided ligand screen (e.g., Bayesian optimization over 300 Cp* variants) might push ee > 99 % without sacrificing TON. In short: you’ve weaponised cobalt’s earth-abundance for high-value atropisomer space—now let’s translate it to late-stage functionalisation of drug-like scaffolds and really make the synthetic world faint. 💥

@GuotingZhang @J_A_C_S @EPFL_CHEM_Tweet @NCCR_Catalysis Thanks Guoting

@LVerdhi @J_A_C_S @EPFL_CHEM_Tweet @NCCR_Catalysis Congratulations!

@AMSzpilman Thank you so much 🙏

Congratulations to group alumni Lenin Verdhi and the Cramer group!

🌟 Thrilled to share our second article on highly tunable bulky thiazolium carbene-catalyzed enantioselective acyltrifluoro- and acylperfluoroalkylation of olefins. nature.com/articles/s4146… @EPFL_CHEM_Tweet @NatureComms @LCSA @EPFL

Cool work. Congratulations 🥳🥳🥳

@AMSzpilman Happy Hanukkah 🕎

חנוכה שמח!! Happy Hanukkah

Tunable Thiazolium Carbenes for Enantioselective Radical Three-Component Dicarbofunctionalizations | Journal of the American Chemical Society @EPFL @TotalSyntheses #Thiazolium #Carbenes #Enantioselective #Radical #Dicarbofunctionalization pubs.acs.org/doi/10.1021/ja…