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📢 A novel gene therapy for #Dravet. jci.org/articles/view/…. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN1A coding sequence into the hippocampus and thalamus of juvenile Dravet mice.
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RubinsteinLab
374 posts
RubinsteinLab
@LabRubinstein
We are located in @TelAvivUni. We study the neuronal and molecular basis for severe epilepsy and autism.
Israel Katılım Ekim 2018
477 Takip Edilen389 Takipçiler
🚨One probe. 🧪One assay. 👯Two answers. Our new fluorescent platform identifies prenylation inhibitors and reveals how they work, streamlining both screening and mechanistic studies. tandfonline.com/doi/full/10.10… @TAUMedFaculty @tasmc1 #MedicinalChemistry #DrugDiscovery
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Sleep and thermoregulation are usually coupled. In our new paper, we find that in a #Dravet syndrome 🐭 this coupling collapses, with sleep failing to induce cooling and warmth failing to promote sleep.
nature.com/articles/s4146…
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In collaboration with Else Tolner (LUMC) and Eric Kremer (CNRS), and the amazing teamwork of Georgii Krivoshein, Hala Majadly, @Anat_Mavashov, Shahak Ranen, Marina Brusel, @iriareyes, and Bernard Boucher 🤩
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This work is dedicated to the memory of Dr. @SajaFadila1, my first student, who led this research 💔
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Congratulation!! 🥳🥳🎈🎈
HaitinLab@HaitinLab
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
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RubinsteinLab retweetledi
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
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RubinsteinLab retweetledi
Excited to share our new paper in @FEBSJournal! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs.7…
@peterslab1 @TAUMedFaculty
HaitinLab@HaitinLab
🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma
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Congratulations!! 🥳🥳
HaitinLab@HaitinLab
How does a cytoplasmic enzyme make a membrane product? 🤔🧬 We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane! MD simulations + fluorescence = mechanistic insight 👇 🔗doi.org/10.1002/pro.70…
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RubinsteinLab retweetledi
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵biorxiv.org/content/early/…
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@HaitinLab @peterslab1 @AlbGiacomello @TAUMedFaculty @of_sagol Congratulations !!🍾💃🪩 an exciting global collaboration 🌍
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💃🕺Happy to share a team effort to uncover the molecular "dance" behind human cis-prenyltransferase regulation!🔬🧬 @peterslab1 @AlbGiacomello #Biochemistry #StructuralBiology @TAUMedFaculty @of_sagol biorxiv.org/content/10.110… biorxiv.org/content/10.110…
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An outstanding group of devoted students - Mor Yam, Jolan Nassir, Danielle Galber, Shir Quinn, Roni Gal, Eden Peled, Mor Ovadia, Mor Bordeynik Cohen; Wayne Frankel, Christopher Makinson, Moran Hausman-Kedem, Aviva Fattal-Valevski. @TAUMedFaculty
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Excited to share our paper! #GRIN2D-DEE 🐭model mirrors patient symptoms, from behavioral deficits and pathological brain activity to synaptic changes🔗 shorturl.at/JL6pyA
An incredible collaboration with a GRIN2D family, @KarenAvraham, researchers & clinicians.
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Thrilled to announce that I've been selected as a 2025 Leon Levy Scholar in Neuroscience! Grateful for this opportunity to advance my research and join a community dedicated to groundbreaking neuroscience in NYC. @NYASciences
NYAS@NYASciences
Congratulations to the 2025 #LeonLevyScholars!🎉 Announcing the 2025 #LeonLevyScholars, in partnership with the Leon Levy Foundation. Recipients participate in a multi-year postdoctoral program to advance their careers. Read more about the Scholars: bit.nyas.org/3Yoa6Pf
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Excited to share our upgraded #CHD2 mouse model! 🐭🧠 It better mimics the disorder, revealing key symptoms like motor deficits, autistic features & altered brain function⚡️
An amazing collaboration with @IgorUlitsky, supported by @curechd2.
🔗 Read more: biorxiv.org/content/10.110…
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RubinsteinLab retweetledi
💖Love, Science & the Brain💖
This #ValentinesDay, meet Profs. Moran Rubinstein & Yoni Haitin - a couple bonded by love & a passion for #neuroscience. From BSc to leading labs, their journey is proof that great discoveries are made together.
🔬 Read more:
linkedin.com/feed/update/ur…
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