Tinnefeld Lab

5/5 Congratulations to the authors🥳 @MartinaPfeiff , Fiona Cole, Dongfang Wang, @YonggangKe and @PhilipTinnefeld

4/5 How? SEPP is a spring-loaded network of DNA “antijunctions” that flip between states, like tiny molecular switches. We can program them with DNA strands to make logic gates, timed actions, and even cargo release. Basically, tiny robots doing science at 1 billionth the size🤏

1/5🚀🔬 New paper alert! We built a spring-loaded DNA origami nanorobot that can sense, compute, and act — basically, a molecular PC made of DNA 🧬💻 #DNAorigami #nanotech #robotics #moleculardesign #SciRobotics science.org/doi/10.1126/sc…

4/4 Huge shout-out to the amazing team🥳:  @TSchroder_ , Julian Bauer, @pa_schueler , @J_Zaehringer , Fiona Cole, @GioFerrari__, Laura Barnard, Karen Gronbach, @GBruggenthies , @PhilipTinnefeld

3/4 MPUs are fully modular🖥️. We built:  ✔ All basic Boolean logic gates  ✔ Multi-input compact gates  ✔ A half adder ✔ Even non-Boolean logic

1/4 📢🥳now online: BROWNIAN DNA COMPUTING - Unlike fuel-driven molecular computing with high-energy barriers, it exploits thermal fluctuations. Inputs rectify state access, enabling fast, low-energy computation. 📜More in our preprint: biorxiv.org/content/10.110…

3/3 Congratulations to all the authors for the team work🥳: @renukka_y, @k_trofymchuk, @MihirDass , Benedkit Hauer, Vivien Behrendt, Jan Schütz, Cindy Close, Michael Scheckenbach, @GioFerrari__, Leoni Mäurer, Sophia Sebina, @glembockyte, Tim Liedl and @PhilipTinnefeld

2/3 We made a short video📽️that provides a quick summary of the topic.

1/3 🚨🥳New paper out in Advanced Materials! We bring attomolar, amplification-free DNA detection to the point-of-care using DNA origami nanoantennas.🧬Check it out here: advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

🎉 Großer Erfolg in der Exzellenzstrategie für die #LMU: Alle sieben beantragten Exzellenzcluster haben sich im Begutachtungsverfahren durchgesetzt und werden ab 2026 für sieben Jahre gefördert! Ein herausragendes Ergebnis! 🎉lmu.de/de/newsroom/ne…

And read the News & Views from @PallavKosuri on this work, here: nature.com/articles/s4159…

Awardees of Römer Prize 2024 presenting their theses: Jakob (Master), Martina (PhD) and @lgrabenhorst_ (PhD). Congrats to all of you!🥳👏 cup.lmu.de/en/latest-news…

Excited to share it now in its final form in @NatureNano: our approach to decouple sensing from signal output to build modular and tunable DNA origami sensors with high FRET contrast: rdcu.be/dZqUd 💡🧬🔬

4/5 Huge congrats to the whole team! Big thanks to @SzalaiAlan, @GioFerrari__, @LarsRichterr for leading this work, and to everyone involved: @AndrsMVera1, @IzabelaKamm, @aksimentievLab , @KushCoshic, Ingrid Tessmer, @PhilipTinnefeld . Exciting GETvNA applications on the way!

4/5 We also applied GETvNA to track the diffusion of AGT along DNA, being able to detect distinctive diffusional modes and preferential binding to A-tracts, while reaching single-base pair resolution.

1/5 DNA and DNA/protein conformations at Ångström/millisecond resolution—right in a fluorescence microscope! Check out our new GETvNA paper in @naturemethods : nature.com/articles/s4159… Want to learn about the science behind GETvNA?