WombacherLab

@TsukijiLab @NatureChemistry Congrats to the team! Fantastic work!!

Excited to share that our AzoTag paper is now out in @NatureChemistry! 🥳 We demonstrate de novo chemo-optogenetics through the rational design of photoresponsive small molecules and selection of their artificial protein binding pairs. nature.com/articles/s4155…

We continue with Richard WOMBACHER for the first oral communication ! #ChemBio2024 @reseauSCF

What a nice way to finish the week! 🎉Our latest paper is now available online in @nchembio. 📚🔬If you missed the pre-print and like biosensors, explore our innovative approach for designing and developing chemogenetic sensors. 💡Check it out here: nature.com/articles/s4158….

The MtL Lecture Series continues! 🎉 Join us on 17 May at 3 pm for an insight into the research of MtL Fellow Petra Schwille from @MPI_Biochem. Register now 👉 bit.ly/3W1z4BB

Do you want to change the color of your biosensor on demand? Still have a large dynamic range? Check our preprint on ChemoX! More about it in the thread! (1/7) Congratulation to the team, in particular the twitterless Lars Hellweg. biorxiv.org/content/10.110…

Hot off the press: @HertenDirk and @LabWombacher jointly developed a single molecule fluorescence screening assay for characterizing fluorogenic click reactions to improve bioorthogonal labelling. Credits go to Felix Hild, @PhilWerther and @KYserentant. sciencedirect.com/science/articl…

A new paper from Kai Johnsson’s group developed a biosensor for visualizing cytosolic and mitochondrial CoA in living cells. Open access: nature.com/articles/s4158…

Happy to share our pre-print about exchangeable HaloTag Ligands (xHTLs): We describe the design and characterization of fluorescent xHTLs expanding the HaloTag repertoire and finding application in 3 super-resolution microscopy techniques! (1/9) biorxiv.org/content/10.110…

@HohlbeinLab @aklymchenko @rhodamine110 Maybe you also want to consider Abberior Flip (still available? @abberior)

Natural product conference #Irsee22 about to start! Great line-up of speakers & topics in the opening session: a talented producer of new natural products, total synthesis of anti-infective drugs & a super-efficient inducer of proximity @DECHEMA @LabWombacher @ChristianJogler

Richard Wombacher and colleagues (@LabWombacher) report a new chemical inducer of proximity based on ABA receptor dimerization by the agrochemical manipropamid. Open access: nature.com/articles/s4158…

I highly recommend HDyes for live-cell imaging!👍 I was very lucky to have the chance to test these new dyes, and they really outperform, with their high SNR for wash-free labeling. Congrats for the nice work!👏

Congratulations to first authors @PhilWerther and @KYserentant and big thanks to all collaboration partners @LemkeLab @LabRadenovic Xiaogang Liu @BuckupTiago @HertenDirk. @mpi_mr_hd @IPMB_HD @UniHeidelberg

We are very happy to see our recent work on fluorogenic tetrazine probes for live cell imaging published in ACS Central Science @ACSCentSci. Check out the new Heidelberg Dyes (HDyes) at pubs.acs.org/doi/10.1021/ac…

We are glad that our fruitful collaboration with @GFantner lead to the advancements in correlative super-resolution and scanning ion-conductance microscopy imaging. We thank all collaborators! @LabWombacher @KYserentant @PhilWerther for fantastic self-blinking dyes

Enzyme units stacked on top of each other like a spinal column – look fabulous and contains some very fascinating research! Out now @NatureMicrobiol nature.com/articles/s4156… mpi-bremen.de/en/Enzyme-skys… @mpi_mr_hd @BarendsThomas @MicroPhys @maxplanckpress #NXR #nitrate #anammox

Excited to share recent @J_A_C_S using far-red silarhodamines to catalyze activation of rapid bioorthogonal chemistry in vivo. Awesome collaborators Zibo Li, Xinqiao Jia, Luke Lavis, & Colin Thorpe. Great dyes make great photocatalysts! @rhodamine110. pubs.acs.org/doi/10.1021/ja…

In our new preprint, we describe a general strategy to transform rhodamines into highly fluorogenic and blinking probes optimized for different imaging applications and labeling systems. biorxiv.org/content/10.110…

My first tweet ever to guide you to our new pre-print about a side-by-side kinetic and structural characterization of HaloTag7, SNAP-tag and CLIP-tag. Now available on biorxiv!! biorxiv.org/content/10.110…

Our Chemical Biology department is offering two #PhD fellowships as part of the #CONSENSE training network. The objectives for the PhD students in the group of Kai Johnsson will be the engineering of new biosensors and biomolecular nanoswitches. Apply now! mr.mpg.de/14507080/job_f…