Hong-Hsi Lee

Can we measure axon diameter from myelin water diffusion? Our latest IEEE TMI paper explores this idea. Paper: doi.org/10.1109/TMI.20… Code: github.com/Connectome20/M… @SusieHuangMDPhD @dimanovikov @elsfi @MGHMartinos @MCB_Harvard @NYUImaging @cai2r

We welcome Connectom.X, the most powerful system for in vivo diffusion #MRI research on the human brain & a new resource for scientists at @nyugrossman & colleagues in the region. cai2r.net/connectom-x-ar… +@elsfi @dimanovikov @SusieHuangMDPhD @nyulangone @NYUImaging @SiemensHealth

How do the cell body size and density change with age in hippocampus? Please check our recent paper on Aging Cell: doi.org/10.1111/acel.7… We apply SANDI (soma and neurite density imaging) to Connectome data (doi.org/10.1038/s41597…) and visualize results using HippUnfold.

Scattering approach to diffusion quantifies axonal damage in brain injury Theoretical physics + ML => sensitivity of diffusion MRI to axonal microstructure by @AliAbdz_ Ricardo Coronado-Leija @Leehhtw @MultiscaleG @elsfi @NYUImaging @cai2r @nyugrossman Link in 1st comment

We segmented myelinated axons in a human subcortical white matter brain sample using U-Net: doi.org/10.1016/j.neur… The code and cell segmentation will be released soon. @QiyuanTian @SusieHuangMDPhD @dimanovikov @elsfi @MGHMartinos @MCB_Harvard @NYUImaging @cai2r

New paper in Imaging Neuroscience by Kwok-Shing Chan, Hong-Hsi Lee, et al: In vivo human neurite exchange time imaging at 500 mT/m diffusion gradients doi.org/10.1162/imag_a…

@ChrisNguyenPhD We have not translated the theory to in vivo data. Our collaborator, Dr. Dan Wu, has observed the kurtosis peak for in vitro organoids. doi.org/10.1126/sciadv…

@Leehhtw Fantastic work! Have you translated this to in vivo ?

What is the time scale to kurtosis peak in a medium of randomly packed permeable cells? Please check our latest paper on MRM for the clean and beautiful answer. doi.org/10.1002/mrm.30… @SusieHuangMDPhD @dimanovikov @elsfi @MGHMartinos @NYUImaging @cai2r

How does the cell body in human cortex change with aging? Please check Dr. Hansol Lee's latest paper selected as a featured cover on Aging Cell. doi.org/10.1111/acel.1… @SusieHuangMDPhD @MGHMartinos

Mapping #Brain Ischemia Pathology with Diffusion #MRI in Organoid Models. #BrainOrganoids#ScienceAdvances By Dan Wu，@Leehhtw Hong-Hsi Lee，Jiangyang Zhang，et al. More Brain & Neural Organoids Research Highlights:isoor.org/brain-neural-o… Article Link: science.org/doi/10.1126/sc…

New paper in Imaging Neuroscience by Ricardo Coronado-Leija, Els Fieremans, et al: Volume electron microscopy in injured rat brain validates white matter microstructure metrics from diffusion MRI doi.org/10.1162/imag_a…

@ismrm2024 sunrise session, Absolute Beginner's Guide to Diffusion Imaging, will start in 10 min at 7am in Nicoll 2. 7am, Diffusion: Fundamentals 7:30am, Diffusion: Clinical Applications

Our paper about diffusion simulation in realistic human brain axons is selected as the Cover Image of NMR in Biomedicine! bit.ly/4a9IEYQ Paper: bit.ly/4acMTTv Github: bit.ly/43AtOZH @SusieHuangMDPhD @dimanovikov @elsfi @MGHMartinos @NYUImaging @cai2r

Our paper about Gibbs ringing correction for partial Fourier acquired data is one of the most downloaded paper in Magn Reson Med! Paper: bit.ly/3qVIFKK GitHub: bit.ly/3ef4HDh #topdownloadedarticle @elsfi @dimanovikov @mrm_highlights @cai2r @NYUImaging

Beadings and undulations can bias axon diameter estimation using dMRI, but what is the effect of each cell feature? Please check our latest preprint about diffusion simulations in realistic human axons on bioRxiv t.ly/cYxv @SusieHuangMDPhD @dimanovikov @elsfi

Hear from bio/medical imaging superstars, discuss challenges & synergies, foster collaborations: July 15-21, 2023 @GordonConf (GRC & GRS) on 𝙏𝙞𝙨𝙨𝙪𝙚 𝙈𝙞𝙘𝙧𝙤𝙨𝙩𝙧𝙪𝙘𝙩𝙪𝙧𝙚 𝙄𝙢𝙖𝙜𝙞𝙣𝙜 Registration is open, limited to 200 -- apply early! grc.org/tissue-microst…

What an amazing #MRhistory has gone through @ISMRM annual meetings. I've had the great pleasure of working with an excellent team of ISMRM Junior Fellows in this project (Thank you for the great work!!). We can't wait to show it to you at the ISMRM next month. It will be fun!

1\ Preprint from the IronTract Challenge!💉🧠 A 2-year effort in the tractography community to find optimal data analysis strategies for HCP-style, multi-shell dMRI & beyond: doi.org/10.1101/2021.1… Major undertaking by @chiaramff @Haber_Lab @QMENTA_Inc & all-⭐️ challenge teams: