LesageFabreLab

72 years ago today, Nobel Laureate Barbara McClintock submitted her discovery of transposons, also known as "jumping genes" which cause the purple spots and streaks on corn kernels.

We are looking for a new postdoc to join our team @irsl in the center of Paris. Interested in transposable elements, genome organization and genome instability? Apply! Know someone who would be interested RT! #postdocposition #transposon #yeast #genome

Congrats to you and co-authors!

In this episode we caught up with @marcotrizzino from @JeffersonUniv to talk about his work on transposable elements in gene regulation and #evolution. #podcast #epigenetics #chromatin Listen here: bit.ly/marco_trizzino

Congratulations for this “tour-de-force”

We are happy to share our new publication on how DAXX safeguards pericentromeric heterochromatin formation inembryonic stem cells gencelldis.fr/publication-un…

New on the control of transposition by the nuclear pore: The results of our collaborative work with @Palancadelab and @AmaBonnet as first author.

We are happy to announce that our latest study is available to read on @bioRxiv! Here we show that “Chromosome structure due to phospho-mimetic H2A modulates DDR through increased chromatin mobility” biorxiv.org/cgi/content/sh… #dnadamageresponse #chromatindynamics

📢Monod-Diderot @IJMonod conferences start again for a new season! See you in the Buffon amphi (with your mask ! 😷) or direct.u-paris.fr/lives on 15/09/20 at 11am. Philippe Pasero👨‍🔬@PaseroLab @IGH_MTP will talk about "Causes and consequences of spontaneous replication stress".

@DuharcourtLab Almost 200 attendees to the inaugural seminar by Vera Gorbunova from @UofR ! Thanks to all of you for making this event a success ! #icte2020 #transposon

Happy to share our new collaborative study showing how "The Rad53-Spt21 and Tel1 axes couple glucose tolerance to histone dosage and subtelomeric silencing" Now online@NATURE COMMS DOI: 10.1038/s41467-020-17961-4

The @FondationARC provides funding for a 2-3 y post-doc in a French lab. Deadline: September 16, 2020. Details at fondation-arc.org/projets/post-d…. DM if interested in joining our team gencelldis.fr in Paris to study Genome Biology : from Mobile DNA to Chromosome Dynamics !

Ongoing somatic transposition in Drosophila associates with inactivation of the tumor suppressor Notch disq.us/t/3qam8a8

Happy to share our new study describing that a small targeting domain in Ty1 integrase is sufficient to direct retrotransposon integration upstream of tRNA genes. Now online@EMBOj. dx.doi.org/10.15252/embj.…

Free access & great line of speakers: Sept-08, 2020 - Vera Gorbunova Sept-22, 2020 - Andrea Betancourt Oct-13, 2020 - Jose Tubio Oct-27, 2020 - Julius Brennecke Nov-10, 2020 - David Ray Nov-24, 2020 - Kazufumi Mochizuki Dec-15, 2020 - Keith Slotkin

Jan-12, 2021 - Maria Costa Jan-26, 2021 - David Bikard Feb-9, 2021 - Joan Curcio Feb-23, 2021 - Alysson Muotri Mar-9, 2021 - Josefa Gonzalez More info on how to connect coming soon.

Save the dates ! The International Congress on Transposable Elements goes virtual (vICTE 2020)! Conferences every two weeks on Tuesdays at 6:00 pm CEST, starting September 8 with Vera Gorbunova. Full program here: icte2020.sciencesconf.org #transposon #icte2020 @INSB_CNRS

Happy to share with you a new preprint of the team showing that SUMOylation of SAMHD1 at Lysine 595 is required for HIV- restriction in non-cycling cells. Congrat' to all authors!biorxiv.org/cgi/content/sh…

Next virtual talk #Clubnoyauk by Pierre Therizols! June 17th 10-10:45am: "Daxx safeguards pericentromere integrity in embryonic stem cells"