Lewin Small

🌟 Exciting News! 🌟 @GardnerPhD joins #ANZOS2024 as a Plenary Speaker! 🎤 Renowned expert in #NutritionalScience, his insights will be thought-provoking. Join us in Sydney, Oct 16-18, for stimulating discussions! anzos.com/anzos-annual-m… #LetsTalkAboutObesity 📊🔬🎉

New #research shows that experiencing less #daylight during winter changes mice’s eating patterns and #metabolism . A researcher says that this discovery could influence experiments with animals involving drugs for #obesity. #sciencenewsdk @LewinSmall sciencenews.dk/en/winter-chan…

We are one of the only countries with a developed research sector that doesn't have an independent research integrity watchdog. The outcome: ⚠️ 500+ papers retracted ⚠️ Drugs based on dodgy data given to patients ⚠️ Fraudulent research getting big $ Here's how to fix it (1/4)

The degree of light exposure we experience may affect how we eat and and burn energy. This may help us understand the link between seasons and metabolism. ☀🌘 The @JuleenRZierath Group examined the metabolism and weight of mice exposed to both ‘winter light’ and ‘summer light’. They found that even in non-seasonal animals, differences in light hours between summer and winter do cause differences in energy metabolism. 🐁 "Do differences in light hours affect energy metabolism? Yes, it does. Further studies in humans may find that altering our exposure to artificial light at night or natural light exposure over the year could be used to improve our metabolic health,” says Professor @JuleenRZierath. 🤸‍♀️ Read the paper in Cell Metabolism, 'Seasonal light hours modulate peripheral clocks and energy metabolism in mice', below 👇 sciencedirect.com/science/articl… Or read the concise news article on our website 👇 cbmr.ku.dk/news/2023/seas… #metabolism #circadianbiology

Seasonal light hours modulate peripheral clocks and energy metabolism in mice: Cell Metabolism Published today! 🍾 ⁦@Cell_Metabolism⁩ ⁦@CellCellPress⁩ Congratulations ⁦@LewinSmall⁩ and team! cell.com/cell-metabolis…

Nature Reviews Endocrinology summarizes our recent study on seasonal light exposure on metabolism by @LewinSmall and team!

that starts one quarter of the way through the dark period. This was a big effort by a great group of people at @Metabolcenter and was enabled by a postdoc fellowship from @DDEA_Denmark.

Additionally, winter mice had higher rhythmicity in daily eating patterns and transcriptional and biochemical measures of fasting. Finally, we found that altering photoperiod phase-shifts peripheral transcriptional rhythmicity with rhythms synchronising to a time scheme cont/

This was a fun study to perform looking at how different photoperiods (hours of light per day) influence energy metabolism and diurnal rhythmicity in mice. @JuleenRZierath @Romain_Barres @Metabolcenter @DDEA_Denmark @Cell_Metabolism sciencedirect.com/science/articl… cont/

Seasonal light hours modulate peripheral clocks and energy metabolism in mice @Cell_Metabolism Our latest from @LewinSmall & colleagues @Metabolcenter @treebak @Romain_Barres Photoperiod modulates energy metabolism & phase shifts peripheral clocks cell.com/cell-metabolis…

Don’t miss out on on the upcoming ANZOS 2023 meeting held in Adelaide 18th-20th October. A great line up of invited speakers including @MMorrisUNSWSyd, Stephen Simpson (@eatlikeanimals), @KateGQuinlan, and Richard Young. @ANZOS_Society

Happy to be part of this study led by @amandabrandon01 and Greg Cooney @CPC_usyd where we found that obese 🐭 fed a palatable hi-carb diet had insulin sensitivity (clamp) and glucose tolerance closer to lean 🐭 than HFD 🐭 with the same adiposity. doi.org/10.7554/eLife.… @eLife

@Peter_Aldiss Definitely looks like one of mine, # no filter

HUGE @LewinSmall trying to use his new phone vibes

@JimJohnsonSci @SisSkovsoe @BruceVerchere @BlumLabWisc Isn’t that the nnt mutation from the C57BL/6J?

@LewinSmall @SisSkovsoe @BruceVerchere @BlumLabWisc The N mutation is known to suppress insulin secretion. How representative of other mouse backgrounds ?

@SisSkovsoe @JimJohnsonSci @BruceVerchere @BlumLabWisc .. studies and have never found a consistent increase in circulating insulin. Whether portal insulin is increased is another question but in this study we see no suppression of hepatic glucose output suggesting that the liver is not seeing much insulin either.

@SisSkovsoe @JimJohnsonSci @BruceVerchere @BlumLabWisc In this model, the C57BL6/N mouse, after a 6 hour fast, we don’t see any rise in circulating insulin during the GTT. This was measured in lean and obese mice and in males and females and from both tail blood and heart blood. I have measured insulin after an ipgTTT for multiple ..

@SisSkovsoe @JimJohnsonSci @BruceVerchere @BlumLabWisc All good points, some of which are addressed in the paper. Another major factor is time of fasting. A rise in insulin during an ipGTT may be more easily detected after an overnight fast due to a lower basal insulin, but an overnight fast in a 🐭 is a big deal compared to 👫

@JimJohnsonSci @BruceVerchere @BlumLabWisc A few other factors that could affect insulin secretion during IPGTTs. The way you restrain the mouse during injection, stress levels, how often you've handled the mice prior to your experiments, the volume of injection solution, how often your insulin samples are thawed... 🐭

@kaesser @JuleenRZierath @MolMetab @Romain_Barres @Metabolcenter This is an important point. We’ve compared GTTs perfomed in the light and dark phases for a study in progress. Very different glucose curves. But hard to know what time to choose if only picking one time point. Maybe around ZT12 when mice have their first big meal of the day?

Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice - ScienceDirect ⁦@MolMetab⁩ Congratulations ⁦@LewinSmall⁩ ⁦@Romain_Barres⁩ and team! ⁦@Metabolcenter⁩ sciencedirect.com/science/articl…

Planning a GTT in mice? Make sure you consider the route of glucose administration. ipGTTs are a non-physiological route of administration, do not promote insulin secretion and have several other differences to the oGTT that may complicate interpretation. sciencedirect.com/science/articl…