Elizabeth (Libby) Russell

"Oral antibiotics can be just as effective as IV and save money, and let patients get home earlier..yes really "

Great day one of Midyear🌟 I presented my poster, saw Viola Davis speak, and attended the residency showcase🎉 Can’t wait for tomorrow😁 @NortheasternSOP @GReardonPharma

pubmed.ncbi.nlm.nih.gov/21367728/ @shannonhchen @BWDionne @davidwkubiak @jeffpears0n

#OTILT 1-3-Beta-D-Glucan is a crucial test in determining the presence of certain fungal infections since BDG is apart of many fungal cell walls. The test is thanks to blood donating horseshoe crabs🦀, whose blood contains amebocytes that activate a coagulation cascade🩸

ncbi.nlm.nih.gov/pmc/articles/P… @shannonhchen @BWDionne @davidwkubiak @jeffpears0n

#OTILT fluconazole should be dose adjusted in renal dysfunction🫘 but are we underdosing? A 2020 study recommends new daily dosing for critically ill patients with invasive candidiasis⬆️: 600mg for adequate renal fxn and 400mg for poor renal function to achieve an AUC/MIC of 100

pubmed.ncbi.nlm.nih.gov/33838004/#:~:t… @shannonhchen @BWDionne @davidwkubiak @jeffpears0n

#OTILT HIV treatment regimens with INSTIs appear to cause weight gain, however this may just be due to the patients in studies switching from TDF to TAF📈 In one US study, switching from TDF to TAF lead to a significant weight gain regardless of the INSTI the pt was on🧐

@shannonhchen @BWDionne @davidwkubiak @jeffpears0n pubmed.ncbi.nlm.nih.gov/31792575/#:~:t….

#OTILT in the case of culture negative septic arthritis, it is prudent to consider mycoplasma as the causative agent🕵️‍♀️ although rare, it is most common in the immunocompromised😷 and should be investigated is there are repeat negative cultures and poor response to empiric abx💊

@shannonhchen @BWDionne @davidwkubiak @jeffpears0n pubmed.ncbi.nlm.nih.gov/17963468/

#OTILT In c. diff negative patients, klebsiella oxytoca is a probable cause of antibiotic-associated hemorrhagic collitis (AAHC)🤒. It produces a cytotoxin that induces epithelial cell death and increases the risk of AAHC in patients on amoxicillin💊

@shannonhchen @BWDionne @davidwkubiak @jeffpears0n ncbi.nlm.nih.gov/pmc/articles/P….

#OTILT chorioamnionitis is an infection of the placenta of a pregnant person🤰, most often due to the ascension of bacteria from the vagina. It often presents as fundal tenderness and tachycardia🫀. Treatment includes ampicillin +ngentamicin +/- clindamycin until delivery👶

pubmed.ncbi.nlm.nih.gov/11427101/ @shannonhchen @BWDionne @jeffpears0n @davidwkubiak

#OTILT what to do if Bactrim is not an option for PJP? Aerosolized pentamidine is an option but is not recommended due to frequent relapse. IV pentamidine is efficacious but comes with many AEs🤕. Best second line in patients without G6PD-deficiency is clindamycin+primaquine✅

@shannonhchen @BWDionne @davidwkubiak @jeffpears0n ncbi.nlm.nih.gov/pmc/articles/P….

#OTILT what is the real answer when a patient asks "can I drink on metronidazole?"🍷we have all heard of the disulfiram reaction causing extreme vomiting🤮 but the evidence is controversial. A small double-blind RCT found no evidence of these symptoms🧐

pubmed.ncbi.nlm.nih.gov/30368737/ @shannonhchen @BWDionne @davidwkubiak @jeffpears0n

#OTLIT fluoroquinolones should be used cautiously in patients with vascular disease 🫀 the class has been associated with significantly increased risk of arrhythmia, MI and CV mortality📈 the worst offender is moxifloxacin and the least bad option is ciprofloxacin