Li-Hsin Chang

307 posts

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Li-Hsin Chang

Li-Hsin Chang

@Lihsin0507

Postdoc @jdavieslab @MRC_WIMM @UniofOxford - 3D genome organization, TADs, CTCF, genome editing & Nanopore sequencing

Oxford, UK Katılım Mayıs 2008
527 Takip Edilen159 Takipçiler
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Elphege Nora Lab at UCSF
Elphege Nora Lab at UCSF@ElphegeNoraLab·
First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)
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Jane Skok
Jane Skok@jane_skok·
Thrilled to share our new preprint, 'A genome wide code to define cell-type specific CTCF binding and chromatin organization'. biorxiv.org/content/10.110…
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Jane Skok
Jane Skok@jane_skok·
Enjoy the weekend, and we’ll see you bright and early at 9:30 AM EST on Monday to kick off #chromatin2024! Fantastic lineup of speakers with discussion to follow each talk. Don’t forget to register if you haven’t yet: bit.ly/chromatin-2024
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Grace Meaker
Grace Meaker@grace_meaker·
Honoured to have been given this award for my short talk at the Oxford MRC Symposium!
MRC WIMM@MRC_WIMM

Congratulations to our students @grace_meaker and @IsaacSWalton, who both won awards at the Oxford MRC Doctoral Training Partnership Symposium (@Oxford_MRC_DTP) earlier today. Grace won the first prize in the student short talks, with her piece on 'The Novel Role of Runx Factors: Regulating Haematopoietic Stem Cell Expansion'. Isaac won the Judge’s Award in the 3-Minute Research Competition. Well done both!

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Tom Milne
Tom Milne@milnetom68·
I'm very happy to see my review on MLL leukemias and enhancer function published in a special issue of Current Opinion in Genetics & Development. Chromatin and aberrant enhancer activity in KMT2A rearranged acute lym... sciencedirect.com/science/articl…
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Jordan Rowley
Jordan Rowley@MJordanRowley·
Check out our new tool: HiCrayon! It's a simple but powerful way of visualizing the overlap between 2D contact maps from Hi-C, Micro-C, etc. and 1D genomics data, such as ChIP-seq and compartment annotations. On BioRxiv and GitHub. biorxiv.org/content/10.110… github.com/JRowleyLab/HiC…
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RDM Researcher Association
RDM Researcher Association@RDMResearcher·
You're invited to come find new science friends! Come join us for a science meet and greet- speed dating style! Learn about your fellow RDM scientists and maybe, find a collab match! Love not guaranteed 😅 Feb 15th at OCDEM. Registration QR below @RDMOxford
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Eileen Furlong
Eileen Furlong@Eileen_Furlong·
Very happy to see our last paper of 2023 is out: The loci of many genes with redundant function (including paralogs) are in close proximity in 3D #Chromatin_loops. We show that such gene-gene loops often involve genes that cross-regulate each other’s expression. 1/4
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Mitch Guttman
Mitch Guttman@mitchguttman·
Gene expression involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. We developed ChIP-DIP – a method for simultaneous, genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. biorxiv.org/content/10.110…
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MRC WIMM
MRC WIMM@MRC_WIMM·
NEW: Researchers from the Laboratory of Gene Regulation, led by @MiraKassouf & Doug Higgs, have identified a new type of non-coding DNA that helps to explain how our DNA is read. 👓🧬 Published today in Cell (@CellCellPress)! Read the full story here: bit.ly/3uQvb91
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Science Magazine
Science Magazine@ScienceMagazine·
How do "molecular motors" fold the genome? A new #SciencePerspective looks at insights that are starting to yield an understanding of the mechanism by which these motors extrude loops of #DNA to structure genomes. scim.ag/4Qj
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Eileen Furlong
Eileen Furlong@Eileen_Furlong·
Exciting times #AI & genomics, gene prediction field, great collab with @stark_lab. Using transfer deep learning to make completely synthetic enhancers with predicted activity (tissue and stage in embryos). Check out the back-to-back complementary lovely paper from @steinaerts
StarkLab@stark_lab

Today, we - @stark_lab and @Eileen_Furlong lab (@EMBLheidelberg) - report the design of 40 synthetic enhancers for 5 tissue types in fruit fly embryos, in vivo. With only a few hundred enhancers per tissue for training, we adopt a stepping-stone transfer-learning approach: (5/N)

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Anders Sejr Hansen
Anders Sejr Hansen@Anders_S_Hansen·
Interesting new from Corri Sept @MartinAryee et al. combines MNase HiChIP for CTCF with new FactorFinder algorithm to profile 3D interactions conditional on CTCF being bound. Nice insights in loop extrusion from the perspective of CTCF-anchored cohesin biorxiv.org/content/10.110…
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Jim R. Hughes
Jim R. Hughes@jrmmhughes·
Our new work asks which genomic elements are capable of setting up cell type-specific regulatory domains? Using analysis of natural variation combined with synthetic biology we show enhancers are both necessary and sufficient for their formation. biorxiv.org/content/10.110…
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Gaëlle Legube lab Chromatin Repair
Gaëlle Legube lab Chromatin Repair@LabLegube·
Our paper is out, Bravo and thanks to all the contributors!!👏👏 Take home: after DSB induction, gH2AX domains self-segregate to form a new chromatin compartment, in which some DDR genes also physically relocate to potentiate their expression. rdcu.be/doT6W
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Keşfet

@grace_meaker @I2BCParisSaclay @bgrdoughty @MichaelaThinks @juliaschaepe @BintuLab @RDMOxford @cdf1530