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Editorial in A&R: Interferon with Still Disease and the Treatment Conundrum
By exploring the role for IFN-I in SD and SD-LD, Ombrello and colleagues have advanced the science/knowledge for this rare condition. While many of the correlations were made using a single timepoint analysis of ISG-28 scores in largely refractory SD patients, the genetic underpinnings support a role for IFN-I in a subset of SD individuals
doi.org/10.1002/art.70…

ACR_Journals@ACR_Journals
A subset of patients with Still’s disease had high type I IFN gene signature assoc with lung disease and drug-assoc immune reactions to IL-1/IL-6 inhibitors. These also linked to rare genetic variation in IFN-related immune pathways A&R doi.org/10.1002/art.70…
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