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Inflammaging: Immune–Metabolic Crosstalk Between the Prostate–Testis & Musculoskeletal System
▶️ Male reproductive aging is increasingly recognized as a systemic process in which inflammaging drives progressive dysfunction of urogenital tissues
▶️ Here, it is proposed a conceptual framework linking the prostate, testis, & skeletal muscle, in which oxidative stress may act as a mediator amplifying systemic dysregulation at different levels during the aging process.
✅️ Lifestyle & metabolic interventions, including caloric restriction, resistance exercise, & selected nutraceuticals, may act as key modulators of inflammaging pathways
mdpi.com/1422-0067/27/8… @HealthyFellow Schematic representation of the major biological processes underlying systemic inflammaging, including chronic low-grade inflammation, immunosenescence, oxidative stress, proteostasis loss, impaired autophagy, inflammasome activation, & apoptosis.
These interconnected mechanisms contribute to functional decline across multiple tissues, including the prostate, testis, & skeletal muscle, promoting age-related reproductive & systemic dysfunctions.
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