Llorca lab

A closer look at the mechanism of microtubule nucleation💫. Thrilled to share our new work revealing CM1-activated gTURC. Great collaboration with @sernarina, @DeBritoClaudia, Thomas Surrey and @LudersLab. @CNIOStopCancer @CRGenomica @IRBBarcelona nature.com/articles/s4146…

Link to the paper: cell.com/structure/full…

Our take on the struture of the R2T complex 🌱 Now out in @Structure_CP! A fun collab led by @alopezperrote and the @AlabadiDavid lab at @IBMCP . Check it out in the next post 👇

The γTuRC saga goes on! This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator. Another tour de force led by @sernarina and Fabian Zimmermann and a fun collab with @LudersLab @IRBBarcelona. authors.elsevier.com/c/1jpyq_Yv6zvB…

Full info, speakers and registration deadlines in: cnio.es/en/eventos/mac…

Join us in sunny Madrid☀️ on May 2025 for "Machines acting on DNA and RNA" at the @CNIOStopCancer All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬 Org: @OscarLlorcaCNIO @rfleiro @NogalesLab +info below 👇

📢Buscamos persona interesada en realizar la tesis doctoral @CIB_CSIC. Ofrecemos contrato predoctoral de 4 años (FPI) para estudiar los mecanismos moleculares de la transposición del ADN usando crio-microscopía electrónica #PIF2024 + info: csic.es/es/formacion-y… RT por favor 🙏

Junior Group Leader positions for AI/BigData, cancer-oriented researchers are available at @CNIOStopCancer. Many fields (Structural Bio, Protein Design, Genomics, Imaging...) are welcome! 🤗 Apply using the link below 👇 and help us spread the word! cnio.es/en/empleo/juni…

And a movie with those beautiful high-res densities 🤓

Thrilled to share our last work @CellRepPhysSci Revealing the molecular mechanism of an anti-tumoral compound inhibiting our favourite system, RUVBL1/2 (at 2.4 Å resolution)🔥 All-@LlorcaLab work led by @CarmenBePaper and @alopezperrote Link below 👇 doi.org/10.1016/j.xcrp…

And also... 🔥pre-print alert🔥 We take a look at our favourite system in plants🌱, the R2T complex, an HSP90 co-chaperone. A study led by @alopezperrote (@CNIOStopCancer) and Alberto Palacios (from @AlabadiDavid's lab at @IBMCP). Check it out 👇 biorxiv.org/content/10.110…

And here goes the link to the paper in @NatureComms 📰 nature.com/articles/s4146…

🔥Paper alert🔥 Another fruitful collaboration with our friends in M. Palacín's lab. Link below 🔗👇 A study led by María Martínez Molledo (@CNIOStopCancer) and Josep Rullo (@IRBBarcelona) elucidating the cryoEM structure of Asc1/CD98hc transporter. Supported by @FundlaCaixa

Hi, we have uploaded a preprint on @bioRxiv_biochem that you may find interesting. It's the result of a fruitful collaboration (@IBMCP) with @LlorcaLab (@CNIOStopCancer) aimed at understanding the role of the HSP90 cochaperone R2T in plants.👇

Double celebration today in the lab! 🎉 Today, our senior postdoc María I. Daudén received the "AECC researcher" grant, followed by our undergrad Celia Varela, also receiving the "AECC lab internship" grant. Proud of you! #TodosContraElCancer @ContraCancerEs @ContraCancerMad

🧬REGISTRATION OPEN🧬 ✈️Come to the @CNIOStopCancer for our Molecular Chaperones in Cancer and Protein Quality Control meeting. ☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!! cnio.es/en/eventos/mol…

@sernarina When your paper gets into @ScienceMagazine we take the red carpet out in the lab...

We are so incredibly proud of @sernarina. Not only is she a cryoEM powerhouse, but she's also a caring mentor and labmate. Definitely a role model. Thanks for your hard work 💕

PAPER ALERT🔥 We took a deep dive into the microtubule 🔍 using cryoEM ❄️🔬to capture the earliest steps of nucleation by the γTuRC complex. With @sernarina and @DeBritoClaudia leading the way. Proud of our collab with the @surrey_lab at the @CRGenomica ! science.org/doi/10.1126/sc…

Primera ‘película’ a escala atómica de microtúbulos en construcción, un proceso clave para la división celular. El @CRGenomica, @CNIOStopCancer y @IBMB_CSIC resuelven un problema clave para la biología: cómo las células construyen sus microtúbulos. ▶️tiny.cc/huemwz