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$TMDX ‘Igloo’ box companies refused to provide their device to participate in OCS2.0 trials comparison for DBD Heart and Lung. Guess what Waleed did? Today TransMedics will unveil its new controlled, active cooling preservation device, the Controlled Hypothermic Organ Preservation System (CHOPS), aimed at facilitating the enrollment of the control arms of the OCS ENHANCE Heart Part B and OCS DENOVO Lung clinical trials. CHOPS will be regulated by the U.S. Food and Drug Administration (FDA) as a new, stand-alone device for controlled hypothermic preservation. Importantly, TransMedics will submit an Investigation Device Exemption (IDE) amendment to allow CHOPS to serve as the control arm for both Part B of ENHANCE Heart and DENOVO Lung Trials.  if approved, this approach would also expand TransMedics' product offerings to include true controlled active cooling preservation devices to serve a broader segment of heart and lung transplant patients globally, based on prospective level 1 evidence. $TMDX enters in cooling preservation devices market as at the end of trials, they will have clinical evidence for OCS2.0 superiority AND alternative offering of Product that dominate DBD market today. So most probably, $TMDX will get PMI post trials for OCS2.0 and CHOPS.

Dr. Makary: "Today, the FDA is also announcing the first ibogaine investigational new drug clearance. This will pave the way for the first ever human trials in the United States."

So UCB is already our partner, them buying Neurona is big because they are a huge company, they can throw lots of money at their programs, ucb has been building out their gene and cell therapies capabilities for quite awhile now, a shitload of money spent. This is the type of company that can scale programs quickly and has the resources to do it. They will also likely throw money at the third program which is Alzheimer’s. It’s not 100 percent confirmed that clearpoint is the partner on that program but they likely are. Basically, this purchase is a huge validation to clearpoint’s platform. UCB is a top dog in epilepsy, they are going to go very big with these 2 epilepsy programs, yes, clearpoint is the partner on the epilepsy programs, they have seen enough to know that these programs are legitimate. Personally, that purchase price will likely look very cheap 3 years from now.

🖥️🔥 Two inmates at an Ohio prison built a secret hacking operation from behind bars, using computers they were supposed to be recycling, they downloaded and sold porn in return for snacks, built a hacker toolkit with Kali Linux and password crackers, and created fake passes to move freely around the facility. All from two secret computers they built from recycling scraps and hid in a ceiling... Marion Correctional Institution in Ohio housed 2,500 inmates.. In 2014, the prison signed a deal with a recycling nonprofit called RET3 to have inmates disassemble old computers for parts. Inmates Adam Johnston and Scott Spriggs had other plans. Instead of breaking the machines down, they rebuilt two fully functioning computers from the scraps. Johnston hid the two PCs on plywood boards in the ceiling above a closet in a third-floor training room. He ran cables from the hidden machines directly into the prison's network switch. To get the computers there, he loaded them onto a hygiene cart alongside soap and shampoo. He wheeled the cart 1,100 feet across the prison, past a corrections officer, through a metal detector, into an elevator, and up three floors. Once connected, Johnston had full internet access and could remote into the hidden computers from any inmate terminal in the facility. He obtained a staff member's login credentials by shoulder surfing, watching him type his password. That password hadn't been changed in years. The prison's systems didn't enforce password rotations, in violation of their own policy. Using the stolen credentials, Johnston accessed DOTS, the state's offender tracking database. He browsed inmate records, searching for a young prisoner serving a long sentence whose identity he could steal. He found Kyle Patrick. Johnston pulled Patrick's Social Security number and date of birth from the system, bypassing a security filter that was supposed to hide SSNs by simply adjusting the browser's view settings. Johnston then applied for five credit and debit cards in Patrick's name. He texted his mother from prison using a free online messaging service and had her provide a neighbor's address across the street as the mailing address. One card, a Visa debit from MetaBank, was approved. His mother received it in the mail, called him at the prison, and read him the card number, expiration date, and activation code over the phone. Johnston activated the card from inside the prison using the hidden computers. Both the application and the activation were traced back to an Ohio state government IP address. He wasn't done. Johnston had also pulled up a Bloomberg article detailing how to file fraudulent tax returns and have refunds wired to prepaid debit cards. That was his next move. The computers were loaded with a full hacker's toolkit: Kali Linux, Wireshark, Nmap, password crackers like Cain and THC Hydra, VPN software, the Tor browser, proxy tools, and encryption software. Investigators also found articles on making homemade drugs, explosives, and fake credit cards. Johnston used DOTS to create fake passes, giving inmates unauthorized access to restricted areas of the prison. He also downloaded pornography onto thumb drives that another inmate sold to other prisoners for commissary items. The scheme only unraveled because the prison upgraded its web filtering software. In early July 2015, the new Websense system flagged Canterbury's credentials being used for three straight hours on a Friday, a day Canterbury didn't work. More alerts followed on Saturday and the following Monday. IT flagged the activity to the warden. Everyone suspected an inmate was involved. Nobody called law enforcement. The prison's IT specialist, Gene Brady, was told exactly which network port the rogue computer was plugged into. He misread the email and checked port 10 instead of port 16. It took him three days to realize his mistake. When Brady finally traced the cable into the ceiling and found the two hidden computers on July 27, he brought two inmates along to help and had them pull the computers down, contaminating the crime scene. He then emailed the warden: "What do you want me to do with the PCs?" The warden admitted he knew illegal activity was occurring but had no answer for why he never reported it to law enforcement. The state highway patrol trooper assigned to investigate crimes at the prison literally shared an office with the prison's own investigator. Neither one was informed. It wasn't until August 7, over a month after the first alert, that anyone reported the incident to the Inspector General or law enforcement. And only because an outside IT security officer told them they were required to. After the discovery, inmates immediately began wiping other prison computers with CCleaner to destroy evidence. Investigators later found the cleaning software had been run at least 10 times in two days, while inmates still had unsupervised access. Four inmates were transferred to separate prisons and placed in segregation with their phone access blocked. Johnston simply used another inmate's PIN to call his mother five more times anyway. When investigators finally seized computers across the prison, they pulled 308 machines. Of those, 291 had no inventory tags. Brady had been swapping recycling-bound computers into the prison network for years without documenting any of it. The investigation uncovered a cascade of failures: no password enforcement, no IT inventory, no crime scene protection, no reporting of illegal activity, and years of unsupervised inmate access to computers, parts, cables, and network infrastructure. The warden resigned.

More info below about the 1st at-home strep throat molecular diagnostic test. Connects virtually to physician via telemedicine & can get antibiotics/meds delivered to home. They have a grant & vetting from NIH & NSF. The team is raising $100K with crowdfunding campaign below:

Hit me with a harsh medical fact.

Allbirds $BIRD to sell its brand and footwear assets, rename itself NewBird AI, and use a new $50M convertible financing facility to buy high-performance GPUs to pivot into AI compute infrastructure.

1. Most penicillin allergies aren’t real. 2. Ancef doesn’t cross react when they are. 3. Even when the reaction is anaphylaxis.