Todd L. Lowary

🔬Publication - by @asibc512 @ACSPublications This study reveals that #SARSCoV2 envelope #protein, a #viroporin that drives #viral assembly, budding, and host interactions, assembles as a pentamer. doi.org/10.1021/acs.jp… #biochemistry #biochem #cryoEM

Synthesis of a glycosyl phospate of glycphosphate :) pnas.org/doi/10.1073/pn…

🔬Publication - by Dr. Meng-Chiao Ho @ACSPublications This study demonstrates the novel design of #encapsulation-stable yet trigger-responsive #liposomes, and how membrane-anchored #peptides interact with membranes. These may lead to new drug design. doi.org/10.1021/jacs.5…

🔬Publication by Dr. Kuen-Phon Wu and Meng-Ru Ho @ACSPublications #Mesostructured #hydration shell in #AI-designed protein variants strengthens the hydrogen bonding network, leading to stable #ubiquitin in extreme heat and pH. doi.org/10.1021/jacs.5… #biochemistry #biochem

🔬Publication - by Dr. Sheng-Wei Lin @SpringerNature Modified soy #isoflavone #cannabinoid receptor 1 #antagonists Daidzein and genistein showed enhanced solubility and bioavailability, and significantly reduced #atherosclerotic #plaque formation in mice. doi.org/10.1186/s12929…

🔬Publication - by Dr. Takashi Angata @CellPressNews Using #genome-wide #knockout screening, #St3gal4, #Lrp1, and #Vps35l were found to contribute to #Siglec-15 ligand expression, thereby regulating #osteoclast differentiation. doi.org/10.1016/j.celr…

🔬Publication - by Dr. Ching-Ching Yu @ACSPublications Using SF17 β-#galactosidase-resistant tagging technique, synthesized #glycans are stable, regioselective, and easily purified. This technique addresses #enzymatic and purification bottlenecks. doi.org/10.1021/acssus…

🔬Publication by Dr. Tzu-Ching Meng @WileyGlobal #Insulin-sensitive #glomerular #podocyte is crucial in kidney health. This study found that protein #tyrosine #phosphatase regulate insulin signaling in podocytes and #vimentin is involved in a key mode. doi.org/10.1002/jcp.70…

🔬Publication - by Dr. Ching-Ching Yu @ACSPublications This study demonstrates an efficient protocol to synthesize #amides using a #formamidine intermediate generated in situ as the nitrogen source. doi.org/10.1021/acs.jo… #bichemistry #thioacid #biochem

🔬Publication - by Dr. James C. Liao @Sciencedirect #Methane #pyrolysis reactors using #carbon-based #catalysts offer net #energy gain of 4.1 times greater than the input, which makes it an energy-efficient #hydrogen production method in power generation. doi.org/10.1016/j.ijhy…

🔬Publication - by @Lowarylab This study reports an efficient synthesis of #thioglycosides from a single commercially available and inexpensive #monosaccharide methyl α-d-mannopyranoside. doi.org/10.1002/ijch.7… #biochemistry #polysaccharide #campylobacter

@sjwill99 @SebVidalChem @acsJACS Yes that too.

@Lowarylab @SebVidalChem @acsJACS I also thing a hydroxyl should me attached through O, not H

What lovely structures. @acsJACS Do better. #badglycans pubs.acs.org/doi/10.1021/ja…

@SebVidalChem @acsJACS Correct if you don’t consider all the weird/incorrect atom alignments on the bonds. Call me I’m old-fashioned but I think a bond to a carboxylic acid should connected to the C. Particularly when published in a leading chemistry journal.

@Lowarylab @acsJACS The abstract is actually correct, right ? But sialic acid is wrong in the only figure with a sugar in the paper 😳

2026 Taiwan International Graduate Program Online Application Application: tigp.apps.sinica.edu.tw/index.phpTIGP Website: tigp.sinica.edu.tw CBMB Website: tigpcbmb.ibc.sinica.edu.tw #taiwan #academiasinica #taiwaninternationalgraduateprogram #phdstudy #studyintaiwan #nangang #Taipei

🔬Publication - by @Lowarylab @NatureComms Using rapid UV #photolysis and cryo-TREM, researchers resolved distinct conformational and dynamic #enzymatic states during the #catalytic mechanism of #glycosyltransferase #GtrB. doi.org/10.1038/s41467… #biochemistry

🔬Publication - by Dr. Meng-Chiao Ho and Peter Chi @NatureComms This study reveals the structures of #RAD51 mini-filaments bound to #homologous #dsDNA, and how RAD51 facilitates strand exchange in homologous #recombination. doi.org/10.1038/s41467… #biochemistry #cryoEM

Cryo-EM shows positively charged surfaces on RAD51 locally destabilize homologous dsDNA to drive strand exchange and D-loop formation for genome stability. Published in Nat Comms by Meng-Chiao Ho's team. sinica.edu.tw/en/news_conten… #StructuralBiology #CryoEM #DNARepair

GlycoNet researchers @ualbertascience report in @ScienceAdvances an ML model that predicted surprising protein-sugar interactions later confirmed in the lab. It can even assess mirror-form sugars rarely found in nature. canadianglycomics.ca/new-machine-le… #Glycotime #Glycomics #Glycobiology

2026 Taiwan International Graduate Program Online Application Application: tigp.apps.sinica.edu.tw/index.php TIGP Website: tigp.sinica.edu.tw CBMB Website: tigpcbmb.ibc.sinica.edu.tw #taiwan #academiasinica #taiwaninternationalgraduateprogram #phdstudy #studyintaiwan #nangang #Taipei