LukeGilbert

We mapped gene interactions across different environmental conditions (GxGxE) at scale for the first time in human cells. These maps lead to the realization that many genes function in a context dependent manner which provides insight into how humans have relatively few genes but many cell types. Congratulations Ben! Paper: cell.com/molecular-cell…

I am so excited to see epigenetic editing (CRISPRoff) move forward as a new approach in medicine through this clinical trial. We hope to make a difference for folks with HBV. Congratulations on a big step forward to all who made this possible! nchromabio.com/press-release/…

Invested in high content CRISPR screening and predictive models? Come to Perturb2026 (March 18/19 2026 in Vienna)! I am co-organizing this conference and am greatly looking forward to what promises to be a fantastic meeting. perturb2026.bio

Too many men die of prostate cancer. We miss you John. We discovered a new way of attacking androgen receptor driven prostate cancers that will lead to new therapeutics. This was a wonderful collaboration with @li_haolong and Felix Feng (rest in peace). doi.org/10.1038/s41588…

A study out today in @NatureGenet from Core Investigator @LukeGilbertSF, @li_haolong & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.

Published today in @NatureBiotech, @LaineGoudy. @LukeGilbertSF, Alex Marson, and colleagues report a new epigenetic editing platform that safely reprograms multiple genes in human T cells without many of the challenges & risks associated with traditional gene editing approaches.

Epigenetic editing opens new opportunities for programming T cells. CRISPRoff can also be combined with genome editing approaches to enable new cell engineering approaches. Congratulations to @LaineGoudy and everyone involved! doi.org/10.1038/s41587…

Excited to see the Virtual Cell competition hosted by Arc Institute. We cant "wet lab" our way through the entire matrix of genes x cell types x environments of interest in biology. Cell state models will accelerate progress. x.com/arcinstitute/s…

Today, Arc announced it is joining forces with @NVIDIAHealth to develop powerful computational tools that will help researchers everywhere explore and understand living systems in ways previously impossible. arcinstitute.org/news/news/arc-…

excited about therapeutic biology? consider joining us! job-boards.greenhouse.io/arcinstitute/j…

Want to start your own lab out of grad school? Our Science Fellow program gives you a springboard to launch your independent career! arcinstitute.org/programs/scien… As a Science Fellow, you’ll enjoy: 💸Unrestricted funding to support your research and a team of 2-4 people 🧪Freedom to pursue curiosity-driven research 🤝Opportunities for cross-discipline collaboration 🔬Robust scientific infrastructure and access to cutting edge Technology Centers So far, Arc has welcomed 2 Science Fellows, @zhou_jingtian and @UcheMedoh, who have already started building their research programs in quantitative modeling of gene expression dynamics and discovering metaboprotein therapeutics for age-related diseases, respectively. Arc is accepting applications for our next Science Fellow to start their lab in 2025. This year, we are looking for an exceptional scientist conducting research in Neurobiology or Immunology to join Arc. Individuals receiving their PhD, MD, or MD/PhD between spring 2023 and summer 2025 are eligible to apply. Make sure to apply by January 15, 2025! arcinstitute.org/programs/searc… Want to learn more? Join Arc co-founder and Core Investigator @pdhsu for a virtual Information Session and Q&A on Friday, December 6, from 10-11am PST. Register here: docs.google.com/forms/d/e/1FAI…

In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

excited to share COMET! A scalable CRISPR approach we (@carwils) developed to identify multidomain proteins that modulate transcription at specific endogenous genomic loci. @arcinstitute @ucsf doi.org/10.1101/2024.1…

💡Arc was founded so that brilliant minds can pursue their boldest ideas. Announcing the newest Investigators and Awardees joining the Arc community! These exceptional scientists are pioneering research into critical questions about complex human disease. Welcome to: 🧑‍🔬Core Investigators @FelixHorns, @ishahjain, and @ChristophThaiss 🔬Science Fellow @UcheMedoh 🦠Innovation Investigators @MaayanLevy_Lab and Theo Roth 💥Ignite Award recipient @weallen1 Next up: applications for the 2025 Investigator cohort are now open! For Core Investigators, apply via our open call or our @UCSF Neurology or @bioe_stanford coordinated searches. Science Fellow and Innovation Investigator candidates may apply through our open call: arcinstitute.org/programs/core-… 👇 Check out our blog to learn more about our Investigator programs, and stay tuned: we'll be introducing you to a new Investigator each day over the next couple of weeks! arcinstitute.org/news/blog/facu…

Happy to report our platform for functional interrogation of cancer and microenvironment cells! Another step toward better treatments for glioblastoma. genomebiology.biomedcentral.com/articles/10.11… @LukeGilbertSF @LabRaleigh @arcinstitute @NeurosurgUCSF

🛠️New CRISPRi tool in @NatureBiotech from @LukeGilbertSF + lab! Until now, scientists have been limited to targeting fewer than 3 genes at a time with CRISPRi. But what about when we want to study more complex combinatorial biology?👇