Martin Fernandez-Zapico Lab

New research study from the @MFZlab team: GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration. doi.org/10.1042/BCJ202…

Our latest research is on the cover of @Biochem_Journal!

Pleased to share our recent study on understanding TGFb-induced EMT in MCF10A cells by taking multidimensional approach. We report the presence of 4 discrete transition states during the EMT process. nature.com/articles/s4146…

Thankful to be a part of this article!portlandpress.com/biochemj/artic…

A new article from the team at the @MFZlab. Great work, Renzo Vera!

GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration portlandpress.com/biochemj/artic…

MFZ Lab Holiday Gathering 2023

A 20y timeline on stage at diagnosis & survival in #PancreaticCancer. Per Cancer Statistics 2003, the five year survival of pancreatic cancer overall was 4%. In 2022 it is 12%. Most of those survival gains have come in localized (17% 👉🏽 44%) & regional (7% 👉🏽 15%) disease.

This year, Mayo Clinic had the honor of providing hope and healing to more than 1.4 million patients and their loved ones. Reflecting on 2022, I am proud of the ways we have created remarkable new ways to shape and transform the future of health care. Happy Holidays to all.

Ok, the numbers say it all… #WorldCup #argentinavspoland

USA’s Antonee Robinson consoles Iran’s Ramin Rezaian after America’s victory. Iran’s regime has tried hard to brainwash its people against the US, but most Americans who’ve been to Iran will tell you it’s among the friendliest places they’ve ever visited.

Remember when Argentina lost its World Cup opener to Saudi Arabia? Yeah, it does seem like a long time ago now. The Albiceleste and Poland advance out of Group C. wapo.st/3gMoYnW

Targeting OXPHOS in frontline setting in advanced #PancreaticCancer - #clinicaltrial open & enrolling at @MDAndersonNews and led by @DrShubhamPant clinicaltrials.gov/ct2/show/NCT05…

.@theNCI wants to hear from you. How will precision prevention of two cancers with rising incidence & high mortality rates - #PancreaticCancer & #LiverCancer - become a reality?Anyone can respond to the RFI (academia, industry, advocacy orgs, lay public). grants.nih.gov/grants/guide/n…

November is a pancreatic cancer awareness month. We took this opportunity to shine a light on this disease and made an informative video to raise public health awareness about pancreatic cancer. #PancreaticCancerAwarenessMonth #pancreaticcancer

New article: Culture media composition influences patient-derived organoids ability to predict therapeutic response in gastrointestinal cancers link.paperbirds.me/SbLDQw #livercancer #oncology

Important preclinical study in @JCI_insight from @MayoClinic team: Culture media composition influences patient-derived organoids ability to predict therapeutic response in gastrointestinal cancers (#PancreaticCancer, #ColorectalCancer) insight.jci.org/articles/view/… Mind your media!

Pretty significant for precision medicine 💊 ❗️ A profound influence of culture media on PDO phenotype, significant difference in response to SoC chemotherapies, distinct morphologies, and transcriptomes between media within the same PDOs cultures

Still a lot of work to do to trust organoids: ⚠️Culture conditions impact drug response insight.jci.org/articles/view/…

In a recently published article in @JCI_insight Jason Doles (@jdoles99), PhD, and his colleagues evaluated a patient-derived organoid’s ability to predict clinical response to gastrointestinal cancers. Learn more: ow.ly/XBhT50LkNuC.