Biochemical Journal

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In this review article from @MFZlab, the authors explore the role of histone lysine methyltransferases in pancreatic ductal adenocarcinoma development, highlighting potential therapeutic targets. #Cancer #Epigenetics doi.org/10.1042/BCJ202…

Constipation is a forerunner to Parkinson’s disease diagnosis, worsening thereafter. New research from Umamahesan et al examines the relationship of intestinal barrier dysfunction to constipation and whether intestinal fungal load is an aggravating factor. doi.org/10.1042/bcj202…

Explore the latest issue of the Biochemical Journal! Featuring the latest research into the aetiopathogenesis of Parkinson’s disease, tau biology, the CRISPR system, arginine metabolism, heme-regulated inhibitor, and cytochrome P450 4A11. ow.ly/m9ZG50WoUor

Delve into the mechanisms of mtDNA replication and repair, and well as how this can lead to mtDNA instability and pathological consequences, in this Biochemical Journal review from Nicholls et al.doi.org/10.1042/BCJ202…

Proteolysis-targeting chimeras (PROTACs) represent a promising modality for probing biological systems and identifying potential therapeutic leads. This review from Osman et al describe the methods used to accelerate PROTAC drug discovery. doi.org/10.1042/bcj202…

Emerging evidence is linking Parkinson’s disease-causing mutations in the LRRK2 gene to dysfunctional axonal transport. This review from Twellsieck et al reviews the role of LRRK2 in axonal transport and Parkinson’s disease.doi.org/10.1042/bcj202…

Arginine is a conditionally essential amino acid, with roles in protein production and intracellular signalling. New research from Hamanaka examined the role and regulation of arginine metabolism in lung fibroblasts activated with TGF-β.doi.org/10.1042/BCJ202…

A massive congratulations to Maxum, Maria Florencia, Eric, Jesús and Nasir, our prize winners from Small G Proteins last week! From oral comms, posters, and audience participation, thank you to @Biochem_Journal, @Cells_MDPI and @FEBS_Letters for sponsoring our #BiochemEvent

Are you interested in the underlying molecular mechanisms of life? Explore the latest completed issue of the Biochemical Journal which delves into the newest developments in this exciting area! ow.ly/3JiA50Wi4Qc

In this new #OA Biochemical Journal review, Cantat & Colin discuss using reconstituted actin networks to model actin-related biological processeshttps://portlandpress.com/biochemj/article/482/11/BCJ20253044/236108/Reconstituted-systems-for-studying-the

Interested in evolutionary biology? This perspective argues that origins of protein kinase A interface with A-Kinase anchoring proteins can be traced to unicellular organisms, which existed long before the emergence of either kinase or anchoring proteins.doi.org/10.1042/bcj202…

New LRRK2 review in the @Biochem_Journal ! Here, @SilasABuck and @LHSanders14 discuss LRRK2’s role in mitochondria and the impact of pathogenic LRRK2 mutations on Parkinson’s diseasehttps://doi.org/10.1042/BCJ20253062

Working in cancer biology? Then explore our latest #cancerbiology review from Sharma et al which delves into the molecular basis and therapeutic implications of binary YAPOn/YAPOff cancer classeshttps://doi.org/10.1042/BCJ20253077

A review regarding the technical advances in ribosome profiling is online! doi.org/10.1042/BST202…

Find out about the complex regulation of catalase during the ripening of pepper fruits, including the key role of nitration, in this Biochemical Journal article from Corpas et al. doi.org/10.1042/BCJ202…

Are you researching new developments in glycobiology? Submit your work to our new special collection on Glycobiology in the Biochemical Journal guest edited by Natasha Zachara. We welcome original research papers, review articles and opinion pieces ow.ly/jauf50W9ApC

Interested in how plants and plant-soil microbe interactions are adapting to climate change? Look no further than the Biochemical Journal’s themed collection on Plants and climate change: the role of plants in achieving net zero doi.org/10.1042/BCJ202…

Nephrin is a central structural and signaling scaffold in kidney filtration. This review from Williamson et al provides an up-to-date account of nephrin signaling and its specialized effects on the uniquely adaptable podocyte. doi.org/10.1042/BCJ202…

Inositol plays key roles in many cellular processes, however, the mechanisms maintaining the homeostasis of the inositol remains poorly understood. New research from Su et al explores cellular inositol metabolism through a newly developed LC-MS method.doi.org/10.1042/bcj202…