Michael Pillinger
12 posts
Michael Pillinger
@MHPillingerMD
Professor @NYULangone, rheumatologist, clinical researcher, lover of literature. Working on treatment of inflammation & COVID-19; US co-PI on #COLCORONA.
Katılım Ocak 2021
327 Takip Edilen377 Takipçiler
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@Boghuma And colchicine does not cure COVID--it mitigates symptoms and prevents progression, a useful adjunct.
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@Boghuma Take the X away from colchicine! RECOVERY was badly designed--testing colchicine in the setting of dex was sloppy. #COLCORONA is well designed-n almost 4500-and shows benefit--don’t throw baby out with bathwater.
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#ColCorona published! (@LancetRespiriMed). For PCR+ #COVID19 outpatients, 0.5 mg daily colchicine reduced hospitalization/pneumonia. Among select populations, NNT was around 30. For the right patients, colchicine is cheap, safe and could save resources and potentially lives.
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Michael Pillinger retweetledi
ColCorona data are online. Still under peer review though! Consideration for early intervention with colchicine if COVID PCR positive outpt and high-risk. Agree, wish gone to the planned n of 6000. MHI had a difficult decision to make during this challenging time. @MHPillingerMD
Eric Topol@EricTopol
The large colchicine RCT for covid is preprint published. It shows some consistent directional benefit for major outcomes medrxiv.org/content/10.110… Since this is a pill, it's safe, cheap & an early intervention (as tested here, before hospital) these findings are very encouraging
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@ashira_md @SciencePharmer That is correct @ashira_md . The study was designed to be “touch less”-drugs were couriered. In the real world, pharmacies deliver.
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@SciencePharmer As far as I know, the medications were sent to the patients by mail to avoid community spread. The logistics would have to be worked out for community use. @MHPillingerMD thoughts?
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Watch: @DavidDavisMP and PM @BorisJohnson discuss #COLCORONA in @UKParliament today!
youtube.com/watch?v=0AYDRO…
YouTube
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@ashira_md @ALGaffoRheumMD @ashira_md, if you view the curves, inflammation starts early post infection but continues to accelerate even as viral load declines. I see it like a runaway train--you want to get the blocks under the wheels before it even leaves the station. Hard to stop a runaway train!
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@MHPillingerMD @ALGaffoRheumMD I wondered about treating early too. Even the SARS CoV-2 MAB treatments didn’t work in hospitalized patients, but did in outpatients. I think these therapies are much more effective in general before someone is sick enough for admission
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Smart idea @ashira_md! Our past research shows colchicine inhibits neutrophil-platelet but not platelet-platelet aggregation. But we hypothesize that inflammasome inhibition may be at least equally important here.
THEE Ashira Blazer MD@ashira_md
@LCalabreseDO @jasonsknight Publication is on the way! @MHPillingerMD and @BinitaShahMD coordinated the NYU site! Very exciting news, I wonder if a neutrophil-centered strategy blocked netosis and therefore platelet aggregation. Can’t wait for the full results!
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Agree completely! I encourage everyone to wait for our paper (coming soon) before drawing conclusions.
Gideon Gil@GideonGil
A gout drug shows promise for Covid-19, but skeptics worry about trusting science by press release statnews.com/2021/01/23/col… via @statnews
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