Miguel Ramalho-Santos Lab

Learn more about the lab's research and news at: mrsantoslab.org and bsky.app/profile/mrsant…

The #LTRI in Toronto is a diverse + and inclusive community in a multicultural city: we encourage candidates from underrepresented groups to apply! 2 PI positions, by Oct 20. #womeninscience #BlackandSTEM #NativeinSTEM #NativeScience #LatinXinSTEM #MarginSci #DiversityinSTEM 👇

🚨 JOB ALERT 🚨 We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at @SinaiHealth. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. Apply now or repost!

@DanielHermes1 @generegulation Updated link as below: genesdev.org/cgi/doi/10.110…

@MRSantosLab @generegulation Link isn’t working for me

Ending 2024 in style! We found that LINE1s are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together 2 facets of Barbara McClintock’s pioneering work: nucleolar organizer regions and transposable elements. genesdev.org/cgi/doi/10.1...

Also noted: Ribosomal DNA copy number is associated with body mass in humans and other mammals. rdcu.be/dZ3q3

Discussed in @MRSantosLab lit review: Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration: Cell cell.com/cell/fulltext/…

Happy Halloween!

In a groundbreaking discovery, Sinai Health researchers have found that transposable DNA elements – long considered “junk DNA” because they had no known function – are critical for early human development. Congrats to Dr. Ramalho-Santos & team at LTRI! sinaihealth.ca/news/new-resea…

@Dev_Cell Highlights: -Knockdown of LINE1 RNA induces reversion of naive hESCs to 8C-like cells -LINE1 RNA and PRC2 maintain nucleolar architecture in hESCs -Disruptions of the nucleolus de-repress the 8C program -Chr19 is enriched for 8C genes and dissociates from the nucleolus in 8CLCs

📢@MRSantosLab - LINE1 RNA prevents developmental reversion of human embryonic stem cells to the 8 cell-like state! + new insights on PRC2, nucleolus and chr. 19. Revised and expanded now @Dev_Cell, free access until Dec 4th (earlier version on bioRxiv): authors.elsevier.com/a/1jxLO5Sx5gxl…

Excellent team effort driven by postdoc Juan Zhang @LesleyZ618, working with Lamisa Mizan @mizanlam and Kirti Mittal in our lab, and in collaboration with Miguel Esteban, @jeffwranalab and @michaelhoffman. Thanks to all! Watch this space for an update in the next few months…

The results point to a conserved role for LINE1 in repression of developmental reversion in both mouse (@MPercharde et al, Cell 2018) and human. The findings raise fascinating questions regarding transposon evolution and their role in genome compartmentalization.

📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells. biorxiv.org/content/10.110… 👇Key findings:

Recent review from @MRSantosLab. Everything you wanted to know about hypertranscription but were afraid to ask! This review discusses concepts of hypertranscription & technological advancements to probe global transcriptional shifts in stem cell biology. cell.com/trends/genetic…

Postdoc positions in the @MRSantosLab! Please RT. Upcoming departure of several very successful lab members + new funding = postdoc positions! Exciting new avenues in mouse development, hypertranscription, dormancy and environment-epigenome interactions. mrsantoslab.org