Gregory Wu

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol 🧵1/ nature.com/articles/s4159…

🚨 Paradigm shift in #MultipleSclerosis 🚨 New study in Nature Medicine shows MS is not fixed subtypes but a dynamic continuum of states across 4 dimensions: disability, brain damage, relapses & silent inflammation. 📖 Read: nature.com/articles/s4159… #MS #Neurology #AI

CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling Check out the paper below 👇 jni-journal.com/article/S0165-…

Murphy Lab Bay #2: proving that science and chaotic shenanigans can coexist. 🙌 @SunnyKimNov2016

Pleased to write this editorial with Larry Steinman about a potential novel antibody in MS neurology.org/doi/10.1212/NX… Original manuscript here: neurology.org/doi/10.1212/NX…

Happy to share this collaborative work looking at long term results of a high efficacy DMT in early #MS #ocrelizumab ⁦@OMRF⁩ ⁦⁦@AaronBosterMD⁩ ⁦@drbarrysinger⁩ ⁦@Brandon_Beaber⁩ ⁦@MSViewsandNews⁩ neurology.org/doi/10.1212/WN…

So proud of this collaborative work! Thanks to all involved, including @Clodida @BrianEdelson2 @maxim_artyomov @mzhlab @jsabatino37

@mzhlab I am proud to share our manuscript published in @ANA_journals today. 🥳doi.org/10.1002/ana.27… We used data-driven approaches to analyze paired #CSF and blood #FlowCytometry of 8,790 (discovery) + 3,201 (validation) patients. A #tweetorial 🧵1/16

Exciting news! Our new paper is published at Annals of Neurology! Check it out to see how large-scale CSF and blood flow cytometry can reveal disease clusters to improve diagnosis and understanding doi.org/10.1002/ana.27…

Using sc-RNA-Seq to delineate T cell changes in AD, demonstrates an up regulation of exhaustion markers in CD8+ T RM cells within 5xFAD mouse brain. Check the link below 👇 jni-journal.com/article/S0165-…

@SaligramaLab I gotta get a pair of those shoes!

#Trio who firmly in the existence of #CD8 #Regulatory #Tcells

I'm excited to announce that Jennifer Lawrence's thesis work is now out! Check it out here: JCI Insight - Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown insight.jci.org/articles/view/…

Post-mortem MS brain display PD1+ Granzyme B+ tissue-resident memory (Trm) T cells in MS lesions, in contact with EBV infected B cells promoting local CNS inflammation. Check out👇 this 2023 interesting study from @FrancescaAloisi sciencedirect.com/science/articl…

@MS_ResearchDoc @KateSadlerPhD Another super important TRP paper that I just came across because of a new paper on how fever impacts CD4 T cell responses by @DarrenHeintzman. Linking the TRPV paper here to add it to this thread: pubmed.ncbi.nlm.nih.gov/32839313/?s=08

Excessive and repetitive Ampicillin treatment alter the gut-brain axis. Ampicillin induce neuroinflammation through NfL, NOS2 and GFP release. Check out 👇 the work by @TouilBoukoffa team. jni-journal.com/article/S0165-…

Incredibly excited to share our latest work exploring the antigen specificity of clonally-expanded CSF-enriched CD8+ T cells in MS  #multiplesclerosis #Tcells #EBV 🧵1/ biorxiv.org/content/10.110…

Attending #ASCP2024? Be sure to stop by our booth and say hello to Nikki!

Incredibly excited to announce that the program will be growing. For 2025, we will be matching 13 applicants (From 11) to a categorical @WashUNeurology PGY-1 position. Ultimately, the program will expand from 44 to 52 residents! @TheNRMP #match2025 #neurotwitter #MedTwitter

Soluble NCAM-1 and VCAM-1 as potential biomarkers for cognitive decline in inactive primary progressive MS. #CognitionDecline #MultipleSclerosis #PPMS #Biomarkers #Onestepforward #CarloscamaralemarroyLab