Claudia Cantoni

We identify FKBP5 as a key regulator of myeloid-driven neuroinflammation in #MS 🔬 Elevated in CSF monocytes & microglia from MS 🧬 Inhibition boosts myelin clearance & reduces IFNγ signaling 🐭 SAFit2 improves EAE outcomes #JournalofNeuroinflammation rdcu.be/e3zGN

Exciting new work in @CellCellPress: a detailed single-cell multiomics atlas of 36 cell types during brain aging in mice. This level of resolution is what we need to track how and why the epigenome changes with age 🧵 cell.com/cell/fulltext/…

Weaning drives microbiome-mediated epigenetic regulation to shape immune memory in mice @NatureMicrobiol @shen_lanlan @BCMFromtheLabs nature.com/articles/s4156…

Aging isn't just a dimmer switch; it’s a logistics failure. In @NatureAging, Doug Henze, Tony Wyss-Coray, and I show how mRNA "gets stuck" in aging microglia, causing degradation of their spatial context: nature.com/articles/s4358…

From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus @ScienceMagazine science.org/doi/10.1126/sc…

A new study from the Icahn School of Medicine at Mount Sinai reveals that major depressive disorder may share key immune abnormalities with inflammatory skin diseases—opening the door to new, targeted treatment strategies. Researchers identified overlap in the Th2 immune pathway, a mechanism well known in conditions like atopic dermatitis, and found that targeting this pathway could offer a novel, personalized approach to treating depression. The findings also highlight the potential of repurposing existing immunology therapies to address psychiatric conditions. “Given the successful translational approach in dermatology, we brought together experts across psychiatry, dermatology, and neuroscience to assess whether a targeted treatment strategy could work in major depressive disorder,” says James Murrough, MD, PhD. Read more mshs.co/3PbENpb

Gut microbes affect #cognition during #ageing nature.com/articles/d4158… #GutMicrobiome #Aging

@biorxivpreprint HLA-DRB1*15:01 drives sex- and age-dependent microglial activation and neuroimmune signaling biorxiv.org/content/10.648… @uarizona

Preprint alert: We report CSF microbiome alterations in tick-borne encephalitis virus infection, identifying distinct profiles linked to disease severity. doi.org/10.21203/rs.3.… Huge thanks to our great collaborators @LabRuzek , @sheppard_lab, and @Eric Blair.

🚨 The largest anxiety GWAS to date JUST dropped Over 850,000 genomes It found 58 risk loci and strongly points to GABAergic signaling as a core driver... ...the same neurons targeted by benzodiazepines. We finally have a robust genetic map for anxiety 🧵

1/9 Every bulk RNA-seq experiment I run goes through the same 7 checks before I trust the results. I've been burned enough times to know: if you skip QC, you will find out the hard way. Usually during a meeting with your collaborator. Here's my checklist:

Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota onlinelibrary.wiley.com/doi/10.1002/ej…

Early-life microbiota disruption-induced deficits in the social brain are sensitive to diet cell.com/iscience/fullt…

Persistent microglial activation following neonatal CMV infection mediates neurodegeneration @ScienceAdvances science.org/doi/10.1126/sc…

"The aim of our study was to determine the genetic architecture of [#MultipleSclerosis] susceptibility in people of #SouthAsian (SAS) and #African (AFR) genetic ancestral backgrounds." doi.org/10.1212/WNL.00… Benjamin Meir Jacobs, @drruthdobson @QMULBartsTheLon

This is super interesting. nature.com/articles/s4158… #neuroimmunology

@biorxivpreprint Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 biorxiv.org/content/10.110…

Myelin sheaths persist for weeks following axon degeneration | Science Advances science.org/doi/10.1126/sc…

One night of sleep loss changes how your brain clears waste: Breakthrough News from PNAS A new study shows sleep deprivation amplifies brain signals tied to CSF flow—possibly a compensatory “cleanup” mechanism. But here’s the problem: By midlife (40–50) that response largely disappears. Sleep deprivation may be quietly accelerating brain aging. #SleepDeprivation #BrainAging #Alzheimers #Neuroscience #Longevity Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity | PNAS pnas.org/doi/10.1073/pn…

Epstein-Barr Virus Antibodies to Differentiate Multiple Sclerosis From Other Neuroinflammatory Diseases jamanetwork.com/journals/jaman…

Data reveals the profound and enduring effect of transient inflammation and, more specifically, type-I-IFN signaling, opening the door for a more nuanced understanding of hematopoietic stem/progenitor cells’ functional modulation. 🔗 ow.ly/t6az50Yo8U9