Marcin J. Suskiewicz

A new group photo on the banks of Loiret ☀️

@Lptomov82 @martinmbauer For what we know, it generally shares the prejudices of its training sets.

@martinmbauer You are missing one great advantage of AI, that we see from chess and go games - it can make moves, or connect ideas we couldn't because it has no prejudices, it can explore the solution space better than us. We limit our thinking by clinging on prejudices.

Yes, this is a significant result and a solid research paper. And it would’ve been much harder to achieve without GPT. While I understand the instinct, I think it is more interesting to evaluate what type of contribution the AI has made as opposed to focussing on how relevant the result is. ChatGPT generalised a previously derived result for an amplitude that was assumed to vanish for all physical kinematics people care about. These amplitudes are very complicated, lengthy expressions with certain structures and symmetries that are sometimes hidden and difficult to see. This kind of problem is exactly where AI shines! AI is better at detecting breast cancer than a clinician because it has seen millions of scans and detects structures where humans -which are limited by their lifetime exposure- can't. AI that systematically surveys many large amplitudes has a similar advantage Similar to the Erdős problems, it was mostly really an attention bottleneck that left this problem unsolved. This calculation was considered another elaborate way of arriving at zero. So few people were interested in the result and even fewer were working on it. Most if not all physicists would therefore consider the insight of the human physicists that there is in fact a kinematic region where these amplitudes are not zero the most meaningful piece of progress here Both these points aren't to diminish the result. It is seriously impressive and deserves the publicity. It shows where the strengths of modern models can significantly accelerate science and I'm convinced there will be even more relevant discoveries in the future.

This thread highlights what I fear will be the degradation of human knowledge due to AI. If I were being charitable, I would say that here Gemini is playing a hybrid role of textbook and tutor, where your tutor has a photographic memory and world class speed reading abilities, but might not be smart enough to get that PhD. So sure, access to that type of tutor is infinitely better than reading baby Rudin in a vacuum. But there is no way AI here is replacing Rudin. Unfortunately though, to a lot of people, it gives the illusion of being better while actually being worse. And thus people will think they are learning more when they are actually learning less.

@nasqret @sama I think they mainly got involved to weaponise the outcome in service of their business (which, by the way, relies on numerous questionable practices, as enthusiasts keep forgetting).

I am very glad you got engaged deep into this experiment. Mathematical community needs strong signal from the AI labs that science is a serious engagement for you. Mathematics in its full proof-driven form is a pinnacle of human ingenuity and knowing how well the models can grasp this challenge is fundamental for the progress.

We went from AI systems that struggled to do grade school math to AI systems that can solve research-level math problems in just a few years. I agree with Jakub this is perhaps the most important eval now. I am also pretty sure the main reaction will be "it's not that hard" :)

@SebastienBubeck How to square this enthusiasm with the ethical and legal practices of this particular company and the whole industry, e.g. in terms of (not) paying for the data used for training?

Well I guess we better deliver now 😅 But srly as I have said before, OAI is just the PERFECT research environment. Ambitious (in particular, non-incremental) research is in the DNA of this place. If that sounds more fun than your current frontier lab, consider joining us!

@davidbessis It was a very nice talk (discussion). Thanks a lot!

C'est demain !

@IvanAhelLab I'd also like to highlight a recent publication by Bernheim and Porier groups et al showing FAM118B, which they call "SIRal", is essential for innate immunity in cellular models; they also have great phylogenetic analysis and insights into biochemistry. science.org/doi/10.1126/sc…

@IvanAhelLab FAM118s have long interested Ivan (my postdoc PI), who, like in many other cases, had a good intuition about their importance. They have been a difficult biochemical target, though. We brought in the observation that they form filaments, an insight explored collaboratively here.

Very happy to share our collaborative project with Ahel and Huet labs et al on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells. nature.com/articles/s4159…

@Eirikvi Have a good sojourn!

Things will only get stranger

Triple Self-Portrait. 1960. Norman Rockwell.

@suzania Gratitude is the reverse of (the reaction to) gift. And as everything is gift, I agree that the right reaction to everything is gratitude.

Gratitude is the foundation for everything. Sorry to earnest-poast but I’m really more and more convinced of this.

Our recent article in Journal of Molecular Biology explores how Post-Translational Modifications (PTMs) orchestrate the repair of trapped Topoisomerase-induced DNA breaks via TDP1 and TDP2. sciencedirect.com/.../pii/S00222… @iacskolkata @IndiaDST @ICMRDELHI @DBTIndia

@johnmilbank3 The Moors, Kidlington

The swing

@johnmilbank3 @johnmilbank3 We spent three years in Kidlington (at the time when I did an interview with you). An underrated place with some genuine community life. The walk to St Mary's church through meadows - and further to Hampton Poyle or to Annie's Tea Rooms in Thrupp - was our favourite

Meadowsweet. The beautiful fenny lands of the reaches of the Cherwell in far north Oxford are rarely discovered by students or even dons.

@johnmilbank3 It's wonderful of you to share these childhood's reads. I have this one already but will look for other books you mentioned today.

Perhaps my very favourite story as a child. In part as it is set in The Cotswolds, where I lived. All her books are charming.

@johnmilbank3 Has just arrived today. Am looking forward to reading it.

Not to be missed