Bruce J MacLachlan

We are excited to share new research from our group! A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. @CellReports cell.com/cell-reports/f…

Finally, some images of the crystals that help to further our understanding of CD4+ T cell / HLA-II biology. 8/8

Massive thanks to the team, Chen, @GallimoreGodkin & collaborators @LongLabGroup. @WelshGovernment/@LlywodraethCym & @wellcometrust for funding this work, @DiamondLightSou (mx beamlines, i04 & i04-1) & @ResearchWales for continued funding. 7/8

Our study on CD4+ T cell epitopes of SARS-CoV-2 is published online in @CellReports. We define model antigens presented by HLA-DR1 and assess the impact of Spike mutations on T cell recognition 1/8. @GallimoreGodkin @CUSystemsImmu cell.com/cell-reports/f…

Extremely excited to start today as a recipient of a Health and Care Research Wales - Health Research Fellowship! Many thanks to the support of @ResearchWales in helping to ask questions about how the immune system recognises cancer.

A tribute to Dr. Ling Felce. I just read about the horrific Oxford accident: a cyclist trapped beneath a lorry and died at the scene. The very same place I hated and dreaded. Then, I found out that the person who died, was my former labmate and friend Ling! I'm shocked and 1/7

New review | Seven mysteries of #LAG3: A multi-faceted #immune receptor of increasing complexity 🔍 🔗buff.ly/3smWcxJ ✍ Stephanie Burnell @Capitani_L @MacLachlanBJ et al. @GallimoreGodkin

@WaelAwadMoh @arc_gov_au @Jamie_Rossjohn @RossjohnLab @MonashBDI @Monash_FMNHS Amazing, congratulations Wael!

It's a great honour to be awarded an @arc_gov_au #DECRA. Looking forward to continuing my research on MR1-mediated immunity. Many thanks, @Jamie_Rossjohn for your enduring support throughout this journey @RossjohnLab @MonashBDI @Monash_FMNHS rms.arc.gov.au/RMS/Report/Dow…

Nothing beats a good “morning ride” 😅 #thealttour

Very pleased to share our study, first author @PiroozZareie, with @RossjohnLab @GrasLab, showing that canonical TCR-pMHC docking is critical for localization of coreceptor-associated Lck to the CD3 complex for signaling @ScienceMagazine @MonashBDI bit.ly/3ifrz8r

New NK cell KIR paper from the lab, in collaboration with Andrew Brooks and Julian Vivian. @MonashBDI @MoradiShoeib nature.com/articles/s4146…

🦠 El ciclo replicativo del #coronavirus pubmed.ncbi.nlm.nih.gov/33258925/

In collaboration with Andrew Brooks' lab and Julian Vivian's lab, latest paper on Natural Killer cell receptor (KIR3DL1) recognition of HLA-I. jimmunol.org/content/early/… @ImagingCoE @TheDohertyInst @MonashBDI

Here's a new review, co-written by me and Prof Andy Sewell, on MR1-restricted T-cells in different disease states, published in Current Opinion in Immunology. Link to the free paper (for 50 days) here! authors.elsevier.com/c/1cNyn3OeyG7D…

the most wholesome way to end the year. Thanks for using my song @dog_rates ♥️