Majzner_Lab

Thank you @psscra @PershingSqFdn @BillAckman @SohnConf for the support of our work to engineer more effective immunotherapies for children and adults with cancer!

@Papa_Heme Give them CAR T cells :)

What am I supposed to do when the rheumatologist tells me my patient doesn’t have lupus but they clearly do?

It’s published. That’s all that matters

Mariella Filbin (@FilbinMariella) is exploring how aggressive childhood brain tumors hijack normal brain activity to repair their own DNA. This research aims to break through radiation resistance in diffuse midline gliomas. 🧠 @DanaFarberNews

Congrats to Kevin Lu from the lab on receiving this great award from @chadtough and the Violet Foundation for Pediatric Cancer! We really appreciate the support and the dedication to help children with DIPG!

Fellowship Grant awarded to Kevin Lu of Dana-Farber Cancer Institute, mentored by Robbie Majzner and Mariella Filbin. (co-funded by the Violet Foundation for Pediatric Brain Cancer) @Majzner_Lab @FilbinMariella

Really excited for the news today as Link Cell Therapies officially launches out of stealth with the announcement of their Series A. The company has been hard at work for several years turning a prototype Boolean-logic AND-gated CAR T cell into a real product with real potential to help patients. With LNK001 headed towards a Phase 1 trial in renal cell carcinoma in 2026, we are excited about the team Link has built - and we hope their work will redefine the universe of antigens and cancers we can target with CAR T cells. Very fortunate to have received backing from @samsaracapital, @JNJInnovation, @bmsnews, @KyowaKirin_US, @Wing_VC, Sheatree Capital, Sherpa Healthcare Partners, & others. fiercebiotech.com/biotech/link-l…

Thanks Ansu for the vote of confidence first in the lab and now with the funding! Really happy to have Wing's backing!

Congratulations to the Link Cell Therapies team on their $60 million Series A! 🚀 prnewswire.com/news-releases/…

STATEMENT BY CHABAD-LUBAVITCH WORLD HEADQUARTERS We are devastated and heartbroken by the barbaric terror attack against a public Chanukah celebration in Sydney, Australia, on the first night of Chanukah. We grieve for the families whose loved ones were murdered, among them Chabad emissary Rabbi Elie Schlanger, who led the Chanukah celebration with the people of Bondi Beach. Rabbi Schlanger devoted his life to sharing Jewish warmth, faith, and community with others. He was doing exactly what he had been sent to do—bringing light and joy into the public square—when his life was cut down. Rabbi Schlanger leaves his wife, Chayale and their children, including a two-month old baby. We mourn him as family and stand with his loved ones and his community in their immeasurable loss. May his memory be for a blessing. We pray that G-d grant healing and comfort to all who survived this attack—men, women, and children—and strength to the families and community now living with its aftermath. Let us be clear: this was a treacherous act of terror—an attack on community, on goodness, and on light itself. It reflects a climate in which Jew-hatred has been allowed to grow and to turn violent. That reality must be confronted. This moment demands accountability. Jewish life must be safeguarded through concrete, heightened measures to deter and rein in calls for violence against Jews. We call on governments and law-enforcement authorities to take responsibility, to strengthen security around Jewish institutions and public gatherings, particularly during Chanukah, when Jewish life is expressed openly and visibly. The Jewish response to terror has never been retreat. Chanukah teaches us to bring light precisely where darkness seeks to intrude. In our times, the Lubavitcher Rebbe, Rabbi Menachem Mendel Schneerson, of blessed memory, insisted that Chanukah lights be placed openly in public spaces as a statement of dignity, faith, and confidence. In that spirit, Chabad-Lubavitch emissaries around the world will continue to light public menorahs—responsibly, in coordination with security authorities, and without surrendering visibility or pride. Jewish life will not be driven from the public square. We will honor the lives taken by enhancing Jewish practice, pride and visibility. May their light rise from this sorrow, and their memory be a blessing to us all. Rabbi Yehuda Krinsky Chairman

@drjgauthier Anakinra definitely gets into the CNS. It's recombinant IL1Ra so pretty small (cytokine sized, smaller than IL-6). It's detectable by ELISA/Luminex for IL1Ra. We found it at ~10% of systemic levels in brain tumor pts treated with CAR T. nature.com/articles/s4158…

One small clarification for the record, in light of Dr. DiPersio's comment that anakinra does not penetrate into the CNS. While anakinra is a large molecule, measurable CSF penetration and CNS biologic activity have been demonstrated in multiple settings of neuroinflammation when high dose of anakinra are administered, including SAH and autoinflammatory CNS disease. A very good example supporting CNS penetration of anakinra is its high efficacy in Neonatal-Onset Multisystem Inflammatory Disease (NOMID), which typically manifests with leptomeningeal inflammation; Left panel, shows brain MRI before anakinra; right panel, after anakinra treatment. From: nejm.org/doi/full/10.10… #neuroinflammation #anakinra

and importantly thanks to our funders including @CancerGrand @TheMarkFdn @CR_UK @NIH @CancerResearch @parkerici @AACR @ASTCT @AICF_nyc @StanfordMCHRI and to our awesome illustrator @TeamSciStories

Thanks to many collaborators on this paper which began while we were at @StanfordMed and was completed @DanaFarber - @Satpathology @CalebLareau @KlebanoffLab @Korbinian_NK @leowanglab @AntigoniMDPhD and to all our wonderful lab members

Congrats to @mcrotiroti on her recent paper published in Nature Cancer now with an accompanying Research Briefing published today: rdcu.be/eQLGF... Mari utilized insights into T cell proximal signaling to overcome antigen-low escape. I have been overdue to write a 🧵!